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Transcriptome signatures of host tissue infected with African swine fever virus reveal differential expression of associated oncogenes
African swine fever (ASF) has emerged as a threat to swine production worldwide. Evasion of host immunity by ASF virus (ASFV) is well understood....
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Differential expression of meiosis and homologous recombination-related genes in the life cycle of Trypanosoma cruzi
Trypanosoma cruzi has a complex life cycle consisting of four morphological and distinct biological stages. Although some authors suggest that T. cruzi ...
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Expression profiles of host miRNAs and circRNAs and ceRNA network during Toxoplasma gondii lytic cycle
Toxoplasma gondii is an opportunistic protozoan parasite that is highly prevalent in the human population and can lead to adverse health consequences...
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Coordination of host and endosymbiont gene expression governs endosymbiont growth and elimination in the cereal weevil Sitophilus spp.
BackgroundInsects living in nutritionally poor environments often establish long-term relationships with intracellular bacteria that supplement their...
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Screening of Genes Associated with Immune Infiltration of Discoid Lupus Erythematosus Based on Weighted Gene Co-expression Network Analysis
Discoid lupus erythematosus (DLE) is a disorder of the immune system commonly seen in women of childbearing age. The pathophysiology and aetiology...
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Plasmodium manipulates the expression of host long non-coding RNA during red blood cell intracellular infection
BackgroundParasites interact with their host through “direct” and/or “indirect” mechanisms. Plasmodium , for example, either mediates direct physical...
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Pan cancer characterization of genes whose expression has been associated with LINE-1 antisense promoter activity
BackgroundLong interspersed nuclear element-1 (LINE-1 or L1) comprises 17% of the human genome. As the only autonomous and active retrotransposons,...
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Upregulation of host genes during disease progression in bovine leukemia virus infection is independent of overexpression of viral transcriptional regulators in vitro
Bovine leukemia virus (BLV) is a member of the genus Deltaretrovirus within the family Retroviridae that infects bovine B cells, causing persistent...
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Profiling and Bioinformatics Analyses of Hypoxia-Induced Differential Expression of Long Non-coding RNA in Glioblastoma Multiforme Cells
Hypoxic microenvironments are intricately linked to malignant characteristics of glioblastoma multiforme (GBM). Long non-coding ribonucleic acids...
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Systematic comparison of published host gene expression signatures for bacterial/viral discrimination
BackgroundMeasuring host gene expression is a promising diagnostic strategy to discriminate bacterial and viral infections. Multiple signatures of...
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HPV18 L1 and long control region sequences variation and E6/E7 differential expression in nasopharyngeal and cervical cancers: a comparative study
BackgroundThe role of high-risk human papillomaviruses (hr-HPVs) in cervical cancer (CC) pathogenesis has long been established. Knowledge about the...
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Host-derived growth factors drive ERK phosphorylation and MCL1 expression to promote osteosarcoma cell survival during metastatic lung colonization
PurposeFor patients with osteosarcoma, disease-related mortality most often results from lung metastasis—a phenomenon shared with many solid tumors....
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Transcriptomic analysis reveals impact of gE/gI/TK deletions on host response to PRV infection
BackgroundPseudorabies virus (PRV) causes substantial losses in the swine industry worldwide. Attenuated PRV strains with deletions of...
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Weighted Gene Co-expression Network Analysis and Machine Learning Validation for Identifying Major Genes Related to Sjogren’s Syndrome
Sjogren’s syndrome (SS) is an autoimmune disorder characterized by dry mouth and dry eyes. Its pathogenic mechanism is currently unclear. This study...
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Genes of the Ubiquitin Proteasome System Qualify as Differential Markers in Malignant Glioma of Astrocytic and Oligodendroglial Origin
We have mined public genomic datasets to identify genes coding for components of the ubiquitin proteasome system (UPS) that may qualify as potential...
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Intrinsic targeting of host RNA by Cas13 constrains its utility
Cas13 can be used for the knockdown, editing, imaging or detection of RNA and for RNA-based gene therapy. Here by using RNA immunoprecipitation...
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Distinct cervical tissue-adherent and luminal microbiome communities correlate with mucosal host gene expression and protein levels in Kenyan sex workers
BackgroundThe majority of studies characterizing female genital tract microbiota have focused on luminal organisms, while the presence and impact of...
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Screening of four lysosome-related genes in sepsis based on RNA sequencing technology
PurposeScreening of lysosome-related genes in sepsis patients to provide direction for lysosome-targeted therapy.
MethodsPeripheral blood samples...
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Comprehensive bioinformatics analysis of human cytomegalovirus pathway genes in pan-cancer
BackgroundHuman cytomegalovirus (HCMV) is a herpesvirus that can infect various cell types and modulate host gene expression and immune response. It...
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Temporal expression of defence and susceptibility genes and tospovirus accumulation in capsicum chlorosis virus-infected capsicum
Yolo Wonder (YW) and Warlock (W), two capsicum cultivars that are susceptible to capsicum chlorosis virus (CaCV), were compared in terms of symptom...
