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Recombinant human diamine oxidase prevents hemodynamic effects of continuous histamine infusion in guinea pigs
ObjectiveTo test whether recombinant human diamine oxidase (rhDAO) with a mutated heparin-binding motif (mHBM), which shows an increased...
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Parasitic Protozoans: Exploring the Potential of N,N’-Bis[2-(5-bromo-7-azabenzimidazol-1-yl)-2-oxoethyl]ethylene-1,3-Diamine and Its Cyclohexyl-1,2-diamine Analogue as TryR and Pf-DHODH Inhibitors
PurposeMajor human parasitic protozoans, such as Plasmodium falciparum and Trypanosoma brucei , cause malaria and trypanosomiasis also known as...
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Diamine oxidase knockout mice are not hypersensitive to orally or subcutaneously administered histamine
ObjectiveTo evaluate the contribution of endogenous diamine oxidase (DAO) in the inactivation of exogenous histamine, to find a mouse strain with...
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Investigating the Anti-inflammatory Effect of Quinoline Derivative: N1-(5-methyl-5H-indolo[2,3-b]quinolin-11-yl)benzene-1,4-diamine Hydrochloride Loaded Soluble Starch Nanoparticles Against Methotrexate-induced Inflammation in Experimental Model
BackgroundIt is necessary to develop advanced therapies utilizing natural ingredients with anti-inflammatory qualities in order to lessen the...
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Bis(thiophen-2-yl-methylene) Benzene-1, 4-Diamine as Fluorescent Probe for the Detection of Fe3+ in Aqueous Samples
A Schiff base bis(thiophen-2-yl-methylene)benzene-1, 4-diamine (L) was synthesized and used for selective and sensitive detection of Fe 3+ . L...
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Antiproliferative effect, cell cycle arrest and apoptosis generation of novel 6-substituted N5-formyltetrahydropyrido[3,2-d]pyrimidine derivatives
Based on our previous work, a novel series of 6-substituted tetrahydropyrido[3,2- d ]pyrimidinesc ( 6a-6k ) bearing formyl group at N 5 -position were...
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Simple, sensitive and specific quantification of diamine oxidase activity in complex matrices using newly discovered fluorophores derived from natural substrates
ObjectiveTo measure diamine oxidase (DAO) activity with high sensitivity in complex matrices like plasma or tissue extracts radioactive putrescine or...
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Synthesis, antitumor activities and functional mechanism of purine derivatives harboring phenyl moieties through three carbon bridges
A series of 2,6-diamine -9H -purine derivatives substituted with phenyl groups at the 8-position through three carbon bridges were synthesized as...
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One Pot Hydrothermal Synthesis and Application of Bright-yellow-emissive Carbon Quantum Dots in Hg2+ Detection
Carbon quantum dots (CQD) have drawn great interest worldwide for their extensive application as sensors due to their extraordinary physical and...
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Plasma diamine oxidase level predicts 6-month readmission for patients with hepatitis B virus-related decompensated cirrhosis
Background and aimsHepatitis B virus-related decompensated cirrhosis is difficult to cure but has a high readmission rate due to multiple...
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Intestinal recruitment of CCR6-expressing Th17 cells by suppressing miR-681 alleviates endotoxemia-induced intestinal injury and reduces mortality
IntroductionSepsis or endotoxemia can induce intestinal dysfunction in the epithelial and immune barrier. Th17 cells, a distinct subset of CD4 + ...
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Mechanisms Underlying the Antiarrhythmic Action of Compound ALM-802
The mechanisms underlying the antiarrhythmic action of compound trihydrochloride N 1 -(2,3,4-trimethoxy)-N 2 -{2-[(2,3,4-trimethoxybenzyl)amino]ethyl}-1,2...
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To the Mechanism of the Antiarrhythmic Action of Compound ALM-802: the Role of Ryanodine Receptors
The effect of the compound N 1 -(2,3,4-trimethoxy)-N 2 -{2-[(2,3,4-trimethoxybenzyl)amino]ethyl}-1,2-ethane-diamine (code ALM-802) on the amplitude of...
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Rice bran oil supplementation protects swine weanlings against diarrhea and lipopolysaccharide challenge
Early weaned piglets suffer from oxidative stress and enteral infection, which usually results in gut microbial dysbiosis, serve diarrhea, and even...
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Luminescent Pyrene-based Schiff base Receptor for Hazardous Mercury(II) Detection Demonstrated by Cell Imaging and Test Strip
Qualitative and quantitative analysis of mercury at concentration levels as low as parts per billion (ppb) is a basic and practical concern. The vast...
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Antifungal activity of aminoalcohols and diamines against dermatophytes and yeast
Dermatomycoses are infections caused by fungi and yeasts and the drug treatment is considered expensive and extensive. Researchers are synthesizing...
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Far-Infrared Therapy Based on Graphene Ameliorates High-Fat Diet-Induced Anxiety-Like Behavior in Obese Mice via Alleviating Intestinal Barrier Damage and Neuroinflammation
The consumption of a high-fat diet (HFD) has been implicated in the etiology of obesity and various neuropsychiatric disturbances, including anxiety...
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Multi-omics reveal mechanisms of high enteral starch diet mediated colonic dysbiosis via microbiome-host interactions in young ruminant
BackgroundAlthough rumen development is crucial, hindgut undertakes a significant role in young ruminants’ physiological development. High-starch...
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The Challenges of Antitubercular Drug Discovery
Although extensive efforts have been undertaken to eradicate tuberculosis (TB), it remains one of the deadliest infections. The rising number of...
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Synthesis and Characterization of a Novel Heterocyclic Schiff Base and Development of a Fluorescent Sensor for Vitamin B12
A heterocyclic Schiff base (MPDPI)was synthesized by the condensation reaction of 1-phenylisatin with 4,5-dimethylphenylene diamine. It was...
