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Cerebellar-Induced Aphasia After Stroke: Evidence for the “Linguistic Cerebellum”
The cerebellum is traditionally known to subserve motor functions. However, for several decades, the concept of the “cerebellar cognitive affective...
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Cortical microstructure in primary progressive aphasia: a multicenter study
BackgroundCortical mean diffusivity is a novel imaging metric sensitive to early changes in neurodegenerative syndromes. Higher cortical mean...
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Diagnostic accuracy of research criteria for prodromal frontotemporal dementia
BackgroundThe Genetic Frontotemporal Initiative Staging Group has proposed clinical criteria for the diagnosis of prodromal frontotemporal dementia...
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Mild behavioral impairment in early Alzheimer’s disease and its association with APOE and BDNF risk genetic polymorphisms
BackgroundMild behavioral impairment (MBI) has been commonly reported in early Alzheimer’s disease (AD) but rarely using biomarker-defined samples....
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Retinal microvasculature dysfunction is associated with Alzheimer’s disease and mild cognitive impairment
BackgroundThe retina and brain share many neuronal and vasculature characteristics. We investigated the retinal microvasculature in Alzheimer’s...
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Selecting and Handling Behavioral Measures for Lesion-Symptom Map**
The success of a lesion-symptom map**Lesion symptom map** (LSM) (LSM) study in answering a specific research question critically depends on how...
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Clinical performance and head-to-head comparison of CSF p-tau235 with p-tau181, p-tau217 and p-tau231 in two memory clinic cohorts
BackgroundCerebrospinal fluid (CSF) p-tau235 is a novel biomarker highly specific of Alzheimer’s disease (AD). However, CSF p-tau235 has only been...
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Let Us Talk Money: Subjectively Reported Financial Performance of People Living with Neurodegenerative Diseases—A Systematic Review
Neurodegenerative diseases (NDDs) form a heterogeneous, widespread group of disorders, generally characterized by progressive cognitive decline and...
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Inference comprehension from reading in individuals with mild cognitive impairment
Inference comprehension is a complex ability that recruits distinct cognitive domains, such as language, memory, attention, and executive functions....
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A systematic survey of advances in retinal imaging modalities for Alzheimer’s disease diagnosis
Recent advances in retinal imaging pathophysiology have shown a new function for biomarkers in Alzheimer’s disease diagnosis and prognosis. The...
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Elevated CSF and plasma complement proteins in genetic frontotemporal dementia: results from the GENFI study
BackgroundNeuroinflammation is emerging as an important pathological process in frontotemporal dementia (FTD), but biomarkers are lacking. We aimed...
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Characteristics of behavioral symptoms in right-sided predominant semantic dementia and their impact on caregiver burden: a cross-sectional study
BackgroundThis study aimed to clarify the neuropsychiatric symptoms of right-sided predominant semantic dementia (SD-R) by comparing them with those...
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Heterogeneity in Alzheimer’s Disease Diagnosis and Progression Rates: Implications for Therapeutic Trials
The clinical presentation and the pathological processes underlying Alzheimer’s disease (AD) can be very heterogeneous in severity, location, and...
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Preliminary validation of the apraxia battery for adults-second edition (ABA-2) in Greek patients with dementia
BackgroundApraxia is considered a supportive feature in Alzheimer’s disease (AD) patients. It has been reported that patients with frontotemporal...
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Tau-PET and in vivo Braak-staging as prognostic markers of future cognitive decline in cognitively normal to demented individuals
BackgroundTo systematically examine the clinical utility of tau-PET and Braak-staging as prognostic markers of future cognitive decline in older...
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Plasma amyloid-β oligomerization assay as a pre-screening test for amyloid status
ObjectiveWe assessed the performance of plasma amyloid oligomerization tendency (OAβ) as a marker for abnormal amyloid status. Additionally, we...
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Neurodegenerative pathologies associated with behavioral and psychological symptoms of dementia in a community-based autopsy cohort
In addition to the memory disorders and global cognitive impairment that accompany neurodegenerative diseases, behavioral and psychological symptoms...
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Measures of Subjective Memory for People with Epilepsy: A Systematic Review of Measurement Properties
People with epilepsy frequently express concern about the burden of memory problems in their everyday lives. Self-report memory questionnaires may...
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Progranulin AAV gene therapy for frontotemporal dementia: translational studies and phase 1/2 trial interim results
GRN mutations cause progranulin haploinsufficiency, which eventually leads to frontotemporal dementia (FTD-GRN). PR006 is an investigational gene...
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An MRI-based strategy for differentiation of frontotemporal dementia and Alzheimer’s disease
BackgroundThe differential diagnosis of frontotemporal dementia (FTD) and Alzheimer’s disease (AD) is difficult due to the overlaps of clinical...
