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Efficacy and mechanism of Shenqi Compound in inhibiting diabetic vascular calcification
BackgroundShenqi Compound (SQC) has been used in clinic for several decades in the prevention and treatment of diabetes and its complications. But...
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Empagliflozin ameliorates vascular calcification in diabetic mice through inhibiting Bhlhe40-dependent NLRP3 inflammasome activation
Type 2 diabetes mellitus (T2DM) patients exhibit greater susceptibility to vascular calcification (VC), which has a higher risk of death and...
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Vascular calcification: from the perspective of crosstalk
Vascular calcification (VC) is highly correlated with cardiovascular disease morbidity and mortality, but anti-VC treatment remains an area to be...
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Long noncoding RNA SNHG1 alleviates high glucose-induced vascular smooth muscle cells calcification/senescence by post-transcriptionally regulating Bhlhe40 and autophagy via Atg10
AbstractLong noncoding RNAs (lncRNAs) are emerging regulators of vascular diseases, yet their role in diabetic vascular calcification/aging remains...
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Glucagon-like peptide-1 receptor agonist exendin 4 ameliorates diabetes-associated vascular calcification by regulating mitophagy through the AMPK signaling pathway
BackgroundVascular calcification (VC) is a complication in diabetes mellitus (DM) patients. Osteogenic phenotype switching of vascular smooth muscle...
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Advanced glycation end products promote meniscal calcification by activating the mTOR-ATF4 positive feedback loop
The meniscus is vital for maintaining knee homeostasis and function. Meniscal calcification is one of the earliest radiological indicators of knee...
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AMPK-mediated autophagy is involved in the protective effect of canagliflozin in the vitamin D3 plus nicotine calcification model in rats
Vascular calcification (VC) is a major risk factor for cardiovascular events. A mutual interplay between inflammation, oxidative stress, apoptosis,...
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Activating BK channels ameliorates vascular smooth muscle calcification through Akt signaling
Vascular calcification (VC) is characterized by pathological depositions of calcium and phosphate in the arteries and veins via an active...
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CADNet: an advanced architecture for automatic detection of coronary artery calcification and shadow border in intravascular ultrasound (IVUS) images
Intravascular Ultrasound (IVUS) is a medical imaging modality widely used for the detection and treatment of coronary heart disease. The detection of...
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Extracellular Vesicles and Vascular Inflammation
Vascular inflammation is the most common pathological feature in the pathogenesis of human disease. It is a complex immune process involved with many...
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Roles of mitochondrial dynamics and mitophagy in diabetic myocardial microvascular injury
Myocardial microvessels are composed of a monolayer of endothelial cells, which play a crucial role in maintaining vascular barrier function, luminal...
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The Role of NLRP3 Inflammasome Activities in Bone Diseases and Vascular Calcification
Continuous stimulation of inflammation is harmful to tissues of an organism. Inflammatory mediators not only have an effect on metabolic and...
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Evaluation of prophylactic efficacy of sodium thiosulfate in combating I/R injury in rat brain: exploring its efficiency further in vascular calcified brain slice model
Cerebral ischemia reperfusion injury (CIR) is one of the clinical manifestations encountered during the management of stroke. High prevalence of...
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The association of moderate-to-vigorous physical activity and sedentary behaviour with abdominal aortic calcification
Background and aimsThe increasing prevalence of metabolic and cardiovascular diseases poses a significant challenge to global healthcare systems....
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Extracellular vesicle miR-32 derived from macrophage promotes arterial calcification in mice with type 2 diabetes via inhibiting VSMC autophagy
BackgroundThe development of diabetes vascular calcification (VC) is tightly associated with the inhibition of vascular smooth muscle cell (VSMC)...
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Type 2 diabetic mellitus related osteoporosis: focusing on ferroptosis
With the aging global population, type 2 diabetes mellitus (T2DM) and osteoporosis(OP) are becoming increasingly prevalent. Diabetic osteoporosis...
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Transcription factors: key regulatory targets of vascular smooth muscle cell in atherosclerosis
Atherosclerosis (AS), leading to gradual occlusion of the arterial lumen, refers to the accumulation of lipids and inflammatory debris in the...
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Role of ENPP1 Gene Variants in the Susceptibility to Diabetic Nephropathy in Patients with type 2 Diabetes Mellitus
Genetic factors are known to play a significant role in the susceptibility of diabetic patients to severe complications such as diabetic nephropathy...
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METTL3-mediated NDUFB5 m6A modification promotes cell migration and mitochondrial respiration to promote the wound healing of diabetic foot ulcer
BackgroundDiabetic foot ulcer (DFU) is the most devastating complication of diabetes mellitus (DM) and plays a major role in disability and death in...
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Cell Therapy of Severe Ischemia in People with Diabetic Foot Ulcers—Do We Have Enough Evidence?
This current opinion article critically evaluates the efficacy of autologous cell therapy (ACT) for chronic limb-threatening ischemia (CLTI),...