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The Neuroprotective Lipocalin Apolipoprotein D Stably Interacts with Specific Subtypes of Detergent-Resistant Membrane Domains in a Basigin-Independent Manner
Accumulated evidence points to the lipocalin apolipoprotein D (ApoD), one of the few genes consistently upregulated upon brain ageing and...
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SARS-CoV-2 accessory protein 7b forms homotetramers in detergent
A global pandemic is underway caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 genome, like its predecessor...
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Caveolin-1 in Müller Glia Exists as Heat-Resistant, High Molecular Weight Complexes
Caveolin-1 (Cav1), the core structural and scaffolding protein of caveolae membrane domains, is highly expressed in many retinal cells and is...
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Supramolecular organization of rhodopsin in rod photoreceptor cell membranes
Rhodopsin is the light receptor in rod photoreceptor cells that initiates scotopic vision. Studies on the light receptor span well over a century,...
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The interaction of heat shock proteins with cellular membranes: a historical perspective
The interaction of heat shock proteins (HSP) with cellular membranes has been an enigmatic process, initially observed by morphological studies,...
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Human tauopathy strains defined by phosphorylation in R1-R2 repeat domains of tau
Distinctive post-translational modifications (PTM) characterize tau inclusions found in tauopathy patients. Using detergent-insoluble tau isolated...
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Biosurfactants as potential and sustainable substitutes for synthetic drugs against antimicrobial resistance and drug adverse effects: a review
In modern medicine, one major advancement recorded is the discovery of antibiotics. For the past decades now, the use and misuse of antibiotics have...
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TM2, a novel semi-synthetic taxoid, exerts anti-MDR activity in NSCLC by inhibiting P-gp function and stabilizing microtubule polymerization
Taxane agents are of particular interest in non-small cell lung carcinomas (NSCLC) treatment, while multidrug resistance (MDR) mediated by...
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Prion Protein Conversion and Lipids
The conversion of α-helical rich normal prion protein to a β-sheeted pathogenic isoform is central to prion disease. Decades of studies provided...
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The role of lipid species in membranes and cancer-related changes
Several studies have demonstrated interactions between the two leaflets in membrane bilayers and the importance of specific lipid species for such...
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β-hydroxybutyrate resensitizes colorectal cancer cells to oxaliplatin by suppressing H3K79 methylation in vitro and in vivo
BackgroundKetone β-hydroxybutyrate (BHB) has been reported to prevent tumor cell proliferation and improve drug resistance. However, the...
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Unique asymmetric distribution of phosphatidylserine and phosphatidylethanolamine in Toxoplasma gondii revealed by nanoscale analysis
Toxoplasma gondii is a highly prevalent obligate apicomplexan parasite that is important in clinical and veterinary medicine. It is known that...
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Glycoform-Selective Prions in Sporadic and Genetic Variably Protease-Sensitive Prionopathies
Unlike other human prion diseases, including the most common Creutzfeldt–Jakob disease (CJD), variably protease-sensitive prionopathy (VPSPr) is...
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SUMOylation regulates the number and size of promyelocytic leukemia-nuclear bodies (PML-NBs) and arsenic perturbs SUMO dynamics on PML by insolubilizing PML in THP-1 cells
The functional roles of protein modification by small ubiquitin-like modifier (SUMO) proteins are not well understood compared to ubiquitination....
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Cannabinoid receptors distribution in mouse cortical plasma membrane compartments
The type 1 and type 2 cannabinoid receptors (CB1 and CB2 receptors) are class A G protein-coupled receptors (GPCRs) that are activated by endogenous...
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A comprehensive ultrastructural analysis of the Toxoplasma gondii cytoskeleton
The invasive nature of Toxoplasma gondii is closely related to the properties of its cytoskeleton, which is constituted by a group of diverse...
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The Immune Barrier: Influence of Food Components on the Intestinal Barrier
The skin and mucous membranes of the body constitute the first defense element of the immune system. Single- to multilayered epithelial end tissues...
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Analysis of Antibacterial Action of Mammalian Host-Defense Cathelicidins and Induction of Resistance to Them in MβL-Producing Pseudomonas aeruginosa
Recombinant analogs of a number of natural host-defense mammalian cathelicidins were obtained and predominant mechanism of their antibacterial action...
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Requirement of Toxoplasma gondii metacaspases for IMC1 maturation, endodyogeny and virulence in mice
BackgroundMetacaspases are multifunctional proteins found in plants, fungi and protozoa, and are involved in processes such as insoluble protein...
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The G51D SNCA mutation generates a slowly progressive α-synuclein strain in early-onset Parkinson’s disease
Unique strains of α-synuclein aggregates have been postulated to underlie the spectrum of clinical and pathological presentations seen across the...
