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Lentinan enhances the antitumor effects of Delta-like 1 via neutrophils
BackgroundSelective activation of Delta-like 1 (DLL1)-Notch signaling is a new approach to activate CD8 + T cell and suppress tumor growth, while the...
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Glutamate Delta-1 Receptor Regulates Inhibitory Neurotransmission in the Nucleus Accumbens Core and Anxiety-Like Behaviors
Glutamate delta-1 receptor (GluD1) is a member of the ionotropic glutamate receptor family expressed at excitatory synapses and functions as a...
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Asiaticoside conveys an antifibrotic effect by inhibiting activation of hepatic stellate cells via the Jagged-1/Notch-1 pathway
The aim of this study was to investigate the underlying protective mechanisms of asiaticoside (AS) against liver fibrosis (LF) both in vivo and in...
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Human HSP70-escort protein 1 (hHep1) interacts with negatively charged lipid bilayers and cell membranes
Human Hsp70-escort protein 1 (hHep1) is a cochaperone that assists in the function and stability of mitochondrial HSPA9. Similar to HSPA9, hHep1 is...
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Inhibition of Delta-like Ligand 4 enhances the radiosensitivity and inhibits migration in cervical cancer via the reversion of epithelial–mesenchymal transition
BackgroundConcurrent chemoradiotherapy is the common first-line treatment for patients with advanced cervical cancer. However, radioresistance...
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Human T-cell lymphotropic virus type 1 (HTLV-1) grip on T-cells: investigating the viral tapestry of activation
IntroductionHuman T-cell Lymphotropic virus type 1 (HTLV-1) belongs to retroviridae which is connected to two major diseases, including...
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Glycerol 3-phosphate dehydrogenases (1 and 2) in cancer and other diseases
The glycerol 3-phosphate shuttle (GPS) is composed of two different enzymes: cytosolic NAD + -linked glycerol 3-phosphate dehydrogenase 1 (GPD1) and...
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Tenets and Methods of Fractal Analysis (1/f Noise)
This chapter deals with the methodical challenges confronting researchers of the fractal phenomenon known as pink or 1/f noise. This chapter...
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Reprogramming of cancer-associated fibroblasts by apoptotic cancer cells inhibits lung metastasis via Notch1-WISP-1 signaling
The interplay between apoptotic cancer cells and the tumor microenvironment modulates cancer progression and metastasis. Cancer-associated...
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Enhancing breadth and durability of humoral immune responses in non-human primates with an adjuvanted group 1 influenza hemagglutinin stem antigen
Seasonal influenza vaccines must be updated annually and suboptimally protect against strains mismatched to the selected vaccine strains. We...
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Delta-8-Tetrahydrocannabinol Exposure and Confirmation in Four Pediatric Patients
IntroductionDelta-8-tetrahydrocannabinol (THC) is a known isomer of delta-9-THC, both found naturally in the Cannabis sativa plant and thought to...
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The role of triggering receptor expressed on myeloid cells-1 (TREM-1) in central nervous system diseases
Triggering receptor expressed on myeloid cells-1 (TREM-1) is a member of the immunoglobulin superfamily and is mainly expressed on the surface of...
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Inactivation of cell-free HIV-1 by designing potent peptides based on mutations in the CD4 binding site
Human immunodeficiency virus type 1 (HIV-1) is a major global health problem, with over 38 million people infected worldwide. Current anti-HIV-1...
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Inducible localized delivery of an anti-PD-1 scFv enhances anti-tumor activity of ROR1 CAR-T cells in TNBC
BackgroundChimeric antigen receptor (CAR)-T cells can induce powerful immune responses in patients with hematological malignancies but have had...
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The Dopaminergic System Modulates the Electrophysiological Activity of the Suprachiasmatic Nucleus Dependent on the Circadian Cycle
The suprachiasmatic nucleus of the hypothalamus (SCN) controls mammalian circadian rhythms. Circadian rhythms influence the dopaminergic system, and...
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Oleuropein-driven reprogramming of the myeloid cell compartment to sensitise tumours to PD-1/PD-L1 blockade strategies
BackgroundPrevious studies have shown that functional systemic immunity is required for the efficacy of PD-1/PD-L1 blockade immunotherapies in...
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Aberrant oscillatory activity in neurofibromatosis type 1: an EEG study of resting state and working memory
BackgroundNeurofibromatosis type 1 (NF1) is a genetic neurodevelopmental disorder commonly associated with impaired cognitive function. Despite the...
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Neuropilin-1 promotes mitochondrial structural repair and functional recovery in rats with cerebral ischemia
ObjectivesAvailable literature documents that ischemic stroke can disrupt the morphology and function of mitochondria and that the latter in other...
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Tumour microenvironment characterisation to stratify patients for hyperthermic intraperitoneal chemotherapy in high-grade serous ovarian cancer (OVHIPEC-1)
BackgroundHyperthermic intraperitoneal chemotherapy (HIPEC) improves survival in patients with Stage III ovarian cancer following interval...
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Bivalent COVID-19 mRNA booster vaccination (BA.1 or BA.4/BA.5) increases neutralization of matched Omicron variants
We report SARS-CoV-2 neutralizing antibody titers in sera of triple-vaccinated individuals who received a booster dose of an original monovalent or a...
