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Intravitreal Delivery of PEGylated-ECO Plasmid DNA Nanoparticles for Gene Therapy of Stargardt Disease
ObjectiveCurrent gene therapy of inherited retinal diseases is achieved mainly by subretinal injection, which is invasive with severe adverse...
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Realizing time-staggered expression of nucleic acid-encoded proteins by co-delivery of messenger RNA and plasmid DNA on a single nanocarrier
Co-delivery of different protein-encoding polynucleotide species with varying expression kinetics of their therapeutic product will become a...
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Transfection with Plasmid-Encoding lncRNA-SLERCC nanoparticle-mediated delivery suppressed tumor progression in renal cell carcinoma
BackgroundThe accumulating evidence confirms that long non-coding RNAs (lncRNAs) play a critical regulatory role in the progression of renal cell...
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Modification of the tumor microenvironment enhances immunity with plasmid gene therapy
Local intratumor delivery with electroporation of low levels of plasmids encoding molecules, induces an antitumor effect without causing systemic...
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Microfluidic Approaches for Gene Delivery and Therapy
Gene editing techniques such as Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR/Cas9) have been developed to target a gene into...
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Aerosolizable Plasmid DNA Dry Powders Engineered by Thin-film Freezing
PurposeThis study was designed to test the feasibility of using thin-film freezing (TFF) to prepare aerosolizable dry powders of plasmid DNA (pDNA)...
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Investigation of the potential therapeutic effect of cationic lipoplex mediated fibroblast growth factor-2 encoding plasmid DNA delivery on wound healing
BackgroundDevelo** an alternative and efficient therapy for wound healing has been an important research topic for pharmaceutical sciences. A...
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ZIF-8 Nanoparticle: A Valuable Tool for Improving Gene Delivery in Sperm-Mediated Gene Transfer
Metal–organic frameworks (MOFs) are porous materials with unique characteristics that make them well-suited for drug delivery and gene therapy...
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Connexin-Containing Vesicles for Drug Delivery
Connexin is a transmembrane protein present on the cell membrane of most cell types. Connexins assemble into a hexameric hemichannel known as...
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Gene Delivery to Chondrocytes
Delivering genes to chondrocytes offers new possibilities both clinically, for treating conditions that affect cartilage, and in the...
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Nano–Bio Interactions: Exploring the Biological Behavior and the Fate of Lipid-Based Gene Delivery Systems
Gene therapy for many diseases is rapidly becoming a reality, as demonstrated by the recent approval of various nucleic acid-based therapeutics....
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Sonoselective delivery using ultrasound and microbubbles combined with intravenous rAAV9 CLDN5-GFP does not increase endothelial gene expression
Transcranial ultrasound combined with intravenous microbubbles can be used to increase blood-brain barrier permeability or, at lower pressures, to...
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Viruses for Systemic Delivery
Adeno-associated virus (AAV) is a nonpathogenic virus that has been leveraged as a gene-delivery vector due to its high transduction efficiency in...
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Structure and Function of Cationic and Ionizable Lipids for Nucleic Acid Delivery
Hereditary genetic diseases, cancer, and infectious diseases are affecting global health and become major health issues, but the treatment...
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Polymeric Systems for Bioinspired Delivery of Angiogenic Molecules
Growth factors are increasingly utilized to promote regeneration of lost or compromised tissues and organs. However, current strategies applying...
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The 60-year evolution of lipid nanoparticles for nucleic acid delivery
Delivery of genetic information to the interior of target cells in vivo has been a major challenge facing gene therapies. This barrier is now being...
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Controlled Delivery of Plasmid DNA to Melanoma Tumors by Gene Electrotransfer
Gene electrotransfer (GET) is a reliable and effective physical method for in vivo delivery of plasmid DNA (pDNA). Several preclinical and clinical...
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Delivery of nucleic acids using nanomaterials
The increasing number of approved nucleic acid therapeutics demonstrates the potential for the prevention and treatment of a broad spectrum of...
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Efficient and scalable gene delivery method with easily generated cationic carbon dots
Gene delivery is a complex process with several challenges when attempting to incorporate genetic material efficiently and safely into target cells....
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Pulmonary Delivery of Nucleic Acids
Pulmonary diseases affect millions of people worldwide and elicit symptoms that may evolve into severe conditions. Despite currently recommended...