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Techniques for Removal and Degradation of Microplastics
This chapter presents remediation techniques to remove and degrade microplastics. Physical treatments include coagulation, flocculation, flotation,...
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Bacterial Degradation of Organic and Inorganic Materials Staphylococcus aureus Meets the Nanoworld
This interdisciplinary work deals with the bacterial degradation of organic and inorganic materials such as prosthetic devices and the consequent...
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Extracellular targeted protein degradation: an emerging modality for drug discovery
Targeted protein degradation (TPD) has emerged in the past decade as a major new drug modality to remove intracellular proteins with bispecific small...
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Assessment of Invadopodium Formation and Gelatin Degradation in Vitro
Some cancer cells form highly regulated structures, termed invadopodia, which mediate local, enzymatic degradation of extracellular matrix and...
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Stress-mediated polysorbate 20 degradation and its potential impact on therapeutic proteins
PurposePolysorbates are the most commonly used surfactants in formulations to stabilize therapeutic proteins against interfacial stresses....
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Influence of Crystal Disorder on the Forced Oxidative Degradation of Vortioxetine HBr
The present study investigates the impact of the solid-state disorder of vortioxetine hydrobromide (HBr) on oxidative degradation under accelerated...
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A Review on Nanomaterial as Photocatalysts for Degradation of Organic Pollutants
Eliminating hazardous organic contaminants from water is a major concern today. Nanomaterials with their textural features, large surface area,...
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MDM2 accelerated renal senescence via ubiquitination and degradation of HDAC1
Senescence, an intricate and inevitable biological process, characterized by the gradual loss of homeostasis and declining organ functions. The...
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A phenomenological model of pulsatile blood pressure-affected degradation of polylactic acid (PLA) vascular stent
The stent implantation may alter the post-operative patient’s blood pressure, and bioresorbable vascular stents (BVS) as a candidate to treat...
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The acute toxicity of Novichok's degradation products using quantitative and qualitative toxicology in silico methods
The emergence of Novichok agents, potent organophosphorus nerve agents, has spurred the demand for advanced analytical methods and toxicity...
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BRD4 promotes gouty arthritis through MDM2-mediated PPARγ degradation and pyroptosis
BackgroundGouty arthritis (GA) is characterized by monosodium urate (MSU) crystal accumulation that instigates NLRP3-mediated pyroptosis; however,...
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Tumor-targeted PROTAC prodrug nanoplatform enables precise protein degradation and combination cancer therapy
Proteolysis targeting chimeras (PROTACs) have emerged as revolutionary anticancer therapeutics that degrade disease-causing proteins. However, the...
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CHMP5 attenuates osteoarthritis via inhibiting chondrocyte apoptosis and extracellular matrix degradation: involvement of NF-κB pathway
BackgroundOsteoarthritis (OA), the most common joint disease, is linked with chondrocyte apoptosis and extracellular matrix (ECM) degradation....
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Heat-shock protein 90α protects NME1 against degradation and suppresses metastasis of breast cancer
BackgroundNME1 has been exploited as a potential translational target for decades. Substantial efforts have been made to upregulate the expression of...
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Targeted degradation of ⍺-synuclein aggregates in Parkinson’s disease using the AUTOTAC technology
BackgroundThere are currently no disease-modifying therapeutics for Parkinson’s disease (PD). Although extensive efforts were undertaken to develop...
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The OX40-TRAF6 axis promotes CTLA-4 degradation to augment antitumor CD8+ T-cell immunity
Immune checkpoint blockade (ICB), including anti-cytotoxic T-lymphocyte associated protein 4 (CTLA-4), benefits only a limited number of patients...
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AQP4 Endocytosis-Lysosome Degradation Mediated by MMP-9/β-DG Involved in Diabetes Cognitive Impairment
Cognitive impairment is considered to be one of the important comorbidities of diabetes, but the underlying mechanisms are widely unknown....
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Secondary, Degradation and Necrobiotic Radiation
This chapter is dealing with specific cases of the previously described mitogenetic effect (Chap. 20 ) and...
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The Effects of Excipients on Freeze-dried Monoclonal Antibody Formulation Degradation and Sub-Visible Particle Formation during Shaking
PurposesWe previously reported an unexpected phenomenon that shaking stress could cause more protein degradation in freeze-dried monoclonal antibody...
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Inhibition of USP10 induces myeloma cell apoptosis by promoting cyclin D3 degradation
The cell cycle regulator cyclin D3 (CCND3) is highly expressed in multiple myeloma (MM) and it promotes MM cell proliferation. After a certain phase...
