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Role of corticosteroids in the treatment of critically ill sepsis patients: a meta-analysis review
ObjectiveIt was to systematically evaluate the effect of corticosteroids on 28d all-cause mortality (ACM), in-hospital death rate, and ICU death rate...
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Sleep in Critically Ill Patient
Sleep is an essential physiological need that allows body and mind to recharge, alert, and restore health which is regulated by circadian rhythm....
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Genetic spectrums and clinical profiles of critically ill neonates with congenital auricular deformity in the China Neonatal Genomes Project
Congenital auricular deformity (CAD) is a complex phenotype that may occur as a single malformation or part of a congenital syndrome. The genetic...
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Relationship of imipenem therapeutic drug monitoring to clinical outcomes in critically ill patients: a retrospective cohort study
The primary objective of this study was to evaluate the predictors associated with target concentration (non-)attainment of imipenem in critically...
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Role of next generation sequencing in diagnosis and management of critically ill children with suspected monogenic disorder
Next generation sequencing based diagnosis has emerged as a promising tool for evaluating critically ill neonates and children. However, there is...
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Perceptions of critically ill individuals with acute and chronic spinal cord injury requiring a tracheostomy tube
Study designObservational study.
ObjectivesTo evaluate the perceptions of patients requiring a tracheostomy tube and to identify possible different...
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Serum trough concentration threshold and risk factors of cefoperazone-induced coagulopathy in critically ill patients: A retrospective case-control study
PurposeTo analyze the risk factors influencing the development of cefoperazone-induced coagulopathy in critically ill patients and determine the...
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Population Pharmacokinetic Modeling and Dose Optimization of Acetaminophen and its Metabolites Following Intravenous Infusion in Critically ill Adults
Background and ObjectiveAcetaminophen (paracetamol) is a ubiquitously administered drug in critically ill patients. Considering the dearth of...
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Large variation in anti-factor Xa levels with nadroparin as thromboprophylaxis in COVID-19 and non-COVID-19 critically ill patients
PurposeCritically ill COVID-19 and non-COVID-19 patients receive thromboprophylaxis with the LMWH nadroparin. Whether a standard dosage is adequate...
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Chest Computed Tomography Characteristics of Critically Ill COVID-19 Patients with Auto-antibodies Against Type I Interferons
PurposePatients with auto-antibodies neutralizing type I interferons (anti-IFN auto-Abs) are at risk of severe forms of coronavirus disease 19...
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Microbiological diagnosis of pulmonary invasive aspergillosis in critically ill patients with severe SARS-CoV-2 pneumonia: a bronchoalveolar study
BackgroundDiagnosing COVID-19-associated pulmonary aspergillosis (CAPA) can be challenging since radiological and clinical criteria in the critically...
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Elevated neutrophil-lymphocyte ratio is associated with high rates of ICU mortality, length of stay, and invasive mechanical ventilation in critically ill patients with COVID-19
Neutrophil and lymphocyte ratio (NLR) has emerged as a complementary marker in intensive care. This study aimed to associate high NLR values with...
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Drug Dosing in Critically Ill Adult Patients with Augmented Renal Clearance
Augmented renal clearance (ARC) is a phenomenon of enhanced renal function seen in critically ill patients. ARC alters the disposition of renally...
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Efficacy and safety of proxalutamide (GT0918) in severe or critically ill patients with COVID-19: study protocol for a prospective, open-label, single-arm, single-center exploratory trial
BackgroundThe rapid worldwide spread of COVID-19 has caused a global health challenge with high mortality of severe or critically ill patients with...
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Failure to predict amikacin elimination in critically ill patients with cancer based on the estimated glomerular filtration rate: applying PBPK approach in a therapeutic drug monitoring study
Abstract PurposeThe aim of this work was to integrate the Therapeutic Drug Monitoring (TDM) with the model-informed precision dosing (MIPD) approach,...
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Urinary Potassium Excretion as a Biomarker in Critically Ill for the Identification of AKI: A Review
Acute kidney injury is one among the common complications in critically ill patients. Early detection and prompt management can fetch out excellent...
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Effect of empirical antifungal treatment on mortality in non-neutropenic critically ill patients: a propensity-matched retrospective cohort study
To evaluate the effect of empirical antifungal treatment (EAFT) on mortality in critically ill patients without invasive fungal infections (IFIs)....
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The benefit of omeprazole exposure on all-cause mortality and length of ICU/hospital stay might vary with age in critically ill pediatric patients: A cohort study
PurposeTo investigate the association between proton pump inhibitors (PPIs) administration during hospitalization and mortality and length of stay in...
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Application of extracorporeal therapies in critically ill COVID-19 patients
The coronavirus disease 2019 (COVID-19) pandemic is a major public health event caused by severe acute respiratory syndrome coronavirus 2...
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Neurofilament Light Chain in the Blood As Biochemical Markers in the Critically Ill
Neurofilament light chain (NfL) is a protein of the neuronal cytoskeleton and a biochemical marker specific for neuroaxonal damage when released and...