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On the physiological and structural contributors to the overall balance of excitation and inhibition in local cortical networks
Overall balance of excitation and inhibition in cortical networks is central to their functionality and normal operation. Such orchestrated...
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Local origin of excitatory–inhibitory tuning equivalence in a cortical network
The interplay between excitation and inhibition determines the fidelity of cortical representations. The receptive fields of excitatory neurons are...
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Rapid fluctuations in functional connectivity of cortical networks encode spontaneous behavior
Experimental work across species has demonstrated that spontaneously generated behaviors are robustly coupled to variations in neural activity within...
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Induction of excitatory brain state governs plastic functional changes in visual cortical topology
Adult visual plasticity underlying local remodeling of the cortical circuitry in vivo appears to be associated with a spatiotemporal pattern of...
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Prefrontal cortical regulation of REM sleep
Rapid eye movement (REM) sleep is accompanied by intense cortical activity, underlying its wake-like electroencephalogram. The neural activity...
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Gamma oscillations provide insights into cortical circuit development
Rhythmic coordination in gamma oscillations provides temporal structure to neuronal activity. Gamma oscillations are commonly observed in the...
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Norepinephrine links astrocytic activity to regulation of cortical state
Cortical state, defined by population-level neuronal activity patterns, determines sensory perception. While arousal-associated...
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Developmental mechanisms underlying the evolution of human cortical circuits
The brain of modern humans has evolved remarkable computational abilities that enable higher cognitive functions. These capacities are tightly linked...
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Cortical regulation of two-stage rapid eye movement sleep
Rapid eye movement (REM) sleep is a sleep state characterized by skeletal muscle paralysis and cerebral cortical activation. Yet, global cortical...
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Pyramidal cell types drive functionally distinct cortical activity patterns during decision-making
Understanding how cortical circuits generate complex behavior requires investigating the cell types that comprise them. Functional differences across...
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Regulation of cortical hyperexcitability in amyotrophic lateral sclerosis: focusing on glial mechanisms
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by the loss of both upper and lower motor neurons,...
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Eplerenone improves hyperglycemia and sympathetic excitation in chronic renocardiac syndrome in rats
We aimed to assess the efficacy of eplerenone, a steroidal mineralocorticoid receptor antagonist known to reduce blood pressure and mitigate...
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The plasticitome of cortical interneurons
Hebb postulated that, to store information in the brain, assemblies of excitatory neurons coding for a percept are bound together via associative...
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Ca2+ Imaging in Immature Cortical Neurons
Ca2+ signaling plays a central role in various neurodevelopmental steps, and immature neurons exhibit spontaneous Ca2+ activity. To analyze Ca2+...
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Multimodal cortical neuronal cell type classification
Since more than a century, neuroscientists have distinguished excitatory (glutamatergic) neurons with long-distance projections from inhibitory...
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Cortico-cortical transfer of socially derived information gates emotion recognition
Emotion recognition and the resulting responses are important for survival and social functioning. However, how socially derived information is...
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Lesion-specific cortical activation following sensory stimulation in patients with subacute stroke
BackgroundSensory stimulation can play a fundamental role in the activation of the primary sensorimotor cortex (S1-M1), which can promote motor...
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Excitation–transcription coupling, neuronal gene expression and synaptic plasticity
Excitation–transcription coupling (E–TC) links synaptic and cellular activity to nuclear gene transcription. It is generally accepted that E–TC makes...
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A Novel Retrograde AAV Variant for Functional Manipulation of Cortical Projection Neurons in Mice and Monkeys
Retrograde adeno-associated viruses (AAVs) are capable of infecting the axons of projection neurons and serve as a powerful tool for the anatomical...
