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Network state transitions during cortical development
Mammalian cortical networks are active before synaptogenesis begins in earnest, before neuronal migration is complete, and well before an animal...
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MRI Data Analysis in Malformations of Cortical Development
Brain magnetic resonance imaging (MRI) is a noninvasive imaging modality that utilizes powerful magnets and radio waves to generate detailed images...
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Gamma oscillations provide insights into cortical circuit development
Rhythmic coordination in gamma oscillations provides temporal structure to neuronal activity. Gamma oscillations are commonly observed in the...
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CT Scan Data Analysis in Malformations of Cortical Development
Malformations of cortical development (MCDs) are a diverse group of disorders that result from abnormal neuronal migration, proliferation, and...
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Intrinsic activity development unfolds along a sensorimotor–association cortical axis in youth
Animal studies of neurodevelopment have shown that recordings of intrinsic cortical activity evolve from synchronized and high amplitude to sparse...
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The Development of Cortical Responses to the Integration of Audiovisual Speech in Infancy
In adults, the integration of audiovisual speech elicits specific higher (super-additive) or lower (sub-additive) cortical responses when compared to...
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Cortical thickness and white matter microstructure predict freezing of gait development in Parkinson’s disease
The clinical applications of the association of cortical thickness and white matter fiber with freezing of gait (FoG) are limited in patients with...
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Genetic insights into human cortical organization and development through genome-wide analyses of 2,347 neuroimaging phenotypes
Our understanding of the genetics of the human cerebral cortex is limited both in terms of the diversity and the anatomical granularity of brain...
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Resha** the Cortical Connectivity Gradient by Long-Term Cognitive Training During Development
The organization of the brain follows a topological hierarchy that changes dynamically during development. However, it remains unknown whether and...
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Comprehensive multi-omic profiling of somatic mutations in malformations of cortical development
Malformations of cortical development (MCD) are neurological conditions involving focal disruptions of cortical architecture and cellular...
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Superficial white matter across development, young adulthood, and aging: volume, thickness, and relationship with cortical features
Superficial white matter (SWM) represents a significantly understudied part of the human brain, despite comprising a large portion of brain volume...
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Sex-specific impacts of prenatal bisphenol A exposure on genes associated with cortical development, social behaviors, and autism in the offspring’s prefrontal cortex
BackgroundRecent studies have shown that prenatal BPA exposure altered the transcriptome profiles of autism-related genes in the offspring’s...
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Post-transcriptional Gene Regulation During Cortical Development
Higher-order cognitive function in mammals is derived from the activity of the cerebral cortex. This brain structure is among the most complex...
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CELF2 Deficiency Demonstrates Autism-Like Behaviors and Interferes with Late Development of Cortical Neurons in Mice
CELF2 variants have been linked to neurodevelopmental disorders (NDD), including autism spectrum disorder (ASD). However, the molecular mechanisms...
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Post-transcriptional Gene Regulation During Cortical Development
Higher-order cognitive function in mammals is derived from the activity of the cerebral cortex. This brain structure is among the most complex...
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Rapamycin Cannot Reduce Seizure Susceptibility in Infantile Rats with Malformations of Cortical Development Lacking mTORC1 Activation
The mechanistic target of the rapamycin (mTOR) pathway is involved in cortical development. However, the efficacy of mTOR inhibitors in malformations...
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Cortical development coupling between surface area and sulcal depth on macaque brains
Postnatal development of cerebral cortex is associated with a variety of neuronal processes and is thus critical to development of brain function and...
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Developmental mechanisms underlying the evolution of human cortical circuits
The brain of modern humans has evolved remarkable computational abilities that enable higher cognitive functions. These capacities are tightly linked...
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Insulin-Like Growth Factor-1 Promotes Synaptogenesis Signaling, a Major Dysregulated Pathway in Malformation of Cortical Development, in a Rat Model
Malformation of cortical development (MCD) is one of the main causes of intractable epilepsy in childhood. We explored a treatment based on molecular...
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Sex differences during development in cortical temporal processing and event related potentials in wild-type and fragile X syndrome model mice
BackgroundAutism spectrum disorder (ASD) is currently diagnosed in approximately 1 in 44 children in the United States, based on a wide array of...
