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Dissecting whole-brain conduction delays through MRI microstructural measures
Network models based on structural connectivity have been increasingly used as the blueprint for large-scale simulations of the human brain. As the...
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Decreased nerve conduction velocity may be a predictor of fingertip dexterity and subjective complaints
We examined the causes of decreased fingertip dexterity in elderly individuals with an aim to improve their quality of life by improving their...
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Age-related increases in cardiac excitability, refractoriness and impulse conduction favor arrhythmogenesis in male rats
The effects of excitability, refractoriness, and impulse conduction have been independently related to enhanced arrhythmias in the aged myocardium in...
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Developmental trajectory of transmission speed in the human brain
The structure of the human connectome develops from childhood throughout adolescence to middle age, but how these structural changes affect the speed...
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Macrophage-specific RhoA knockout delays Wallerian degeneration after peripheral nerve injury in mice
BackgroundPlenty of macrophages are recruited to the injured nerve to play key roles in the immunoreaction and engulf the debris of degenerated axons...
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Clemastine Enhances Myelination, Delays Axonal Loss and Promotes Functional Recovery in Spinal Cord Injury
Recent evidence has shown that demyelination occurs along with axonal degeneration in spinal cord injury (SCI) during the secondary injury phase....
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Interaural Sequential Masking in the Dolphin Auditory System
Studies in a bottlenose dolphin Tursiops truncatus measured the time of release of short-latency auditory evoked potentials (auditory brainstem...
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Axonal membrane stretch suppresses neuronal excitability by activating mechanosensitive K2P channels at the node of Ranvier
Saltatory conduction is the propagation of action potentials along myelinated nerves, which enables fast propagation through the node of Ranvier....
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An Overview of Spiral- and Scroll-Wave Dynamics in Mathematical Models for Cardiac Tissue
We provide a brief overview of recent numerical studies of spiral- and scroll-wave dynamics in mathematical models of cardiac tissue. These waves are... -
Nerve Conduction and Neuromuscular Transmission in C57Bl/6 Mice with Genetically Determined Peripheral Neuropathy
Charcot–Marie–Tooth disease is one of the most widespread forms of hereditary peripheral neuropathy in humans. C57Bl/6 mice are considered the most...
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A model description of beta oscillations in the external globus pallidus
The external globus pallidus (GPe), a subcortical nucleus located in the indirect pathway of the basal ganglia, is widely considered to have tight...
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Motor learning drives dynamic patterns of intermittent myelination on learning-activated axons
Myelin plasticity occurs when newly formed and pre-existing oligodendrocytes remodel existing patterns of myelination. Myelin remodeling occurs in...
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Altered Cortical Activity during a Finger Tap in People with Stroke
This study describes electroencephalography (EEG) measurements during a simple finger movement in people with stroke to understand how temporal...
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How the conception of control influences our understanding of actions
Wilful movement requires neural control. Commonly, neural computations are thought to generate motor commands that bring the musculoskeletal system —...
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Bypassing the volume conduction effect by multilayer neural network for effective connectivity estimation
Differentiation of real interactions between different brain regions from spurious ones has been a challenge in neuroimaging researches. While using...
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Structure and Function of Sodium Channel Nav1.3 in Neurological Disorders
Nav1.3, encoded by the SCN3A gene, is a voltage-gated sodium channel on the cell membrane. It is expressed abundantly in the fetal brain but little...
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Outgrowing seizures in Childhood Absence Epilepsy: time delays and bistability
We formulate a conductance-based model for a 3-neuron motif associated with Childhood Absence Epilepsy (CAE). The motif consists of neurons from the...
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Perceptual simultaneity between nociceptive and visual stimuli depends on their spatial congruence
To protect our body against physical threats, it is important to integrate the somatic and extra-somatic inputs generated by these stimuli. Temporal...
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Dark Rearing in the Visual Critical Period Causes Structural Changes in Myelinated Axons in the Adult Mouse Visual Pathway
An appropriate sensory experience during the early developmental period is important for brain maturation. Dark rearing during the visual critical...
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P2X7 receptor antagonists modulate experimental autoimmune neuritis via regulation of NLRP3 inflammasome activation and Th17 and Th1 cell differentiation
BackgroundGuillain–Barré syndrome (GBS), a post-infectious, immune-mediated, acute demyelinating disease of the peripheral nerves and nerve roots,...