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Dysregulation of iron homeostasis and methamphetamine reward behaviors in Clk1-deficient mice
Chronic administration of methamphetamine (METH) leads to physical and psychological dependence. It is generally accepted that METH exerts rewarding...
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Opposing roles of CLK SR kinases in controlling HIV-1 gene expression and latency
BackgroundThe generation of over 69 spliced HIV-1 mRNAs from one primary transcript by alternative RNA splicing emphasizes the central role that RNA...
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Computer-Assisted Drug Design: A Toolbox for Novel Tau Kinase Inhibitors and Its Implications in Alzheimer’s Disease
Kinases/phosphatases are a novel class of enzymes that maintains the equilibrium of the amino acids’ optimum phosphorylation/dephosphorylation...
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2-Desaza-annomontine (C81) impedes angiogenesis through reduced VEGFR2 expression derived from inhibition of CDC2-like kinases
Angiogenesis is a crucial process in the progression of various pathologies, like solid tumors, wet age-related macular degeneration, and chronic...
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Proteases and Protein Kinases as Potential Drug Target
Recently, the successful pharmacological targeting of protein and phosphoinositide kinases has been applied to a wide range of diseases, most notably...
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The role, mechanism, and application of RNA methyltransferase METTL14 in gastrointestinal cancer
Gastrointestinal cancer is the most common human malignancy characterized by high lethality and poor prognosis. Emerging evidences indicate that...
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Dual Specificity Tyrosine Phosphorylation-Regulated Kinase 1A (DYRK1A) Inhibitors: The Quest for a Disease-Modifying Treatment for Alzheimer’s Disease
Alzheimer’s disease (AD) is a multifactor disease that is a most familiar form of dementia. Neurofibrillary tangles (NFTs) and amyloid-β (Aβ) are the...
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Splicing alterations in pancreatic ductal adenocarcinoma: a new molecular landscape with translational potential
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal cancers worldwide, mainly due to its late diagnosis and lack of effective...
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Alternative splicing as a source of phenotypic diversity
A major goal of evolutionary genetics is to understand the genetic processes that give rise to phenotypic diversity in multicellular organisms....
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Mechanism of action deconvolution of the small-molecule pathological tau aggregation inhibitor Anle138b
BackgroundA key histopathological hallmark of Alzheimer’s disease (AD) is the presence of neurofibrillary tangles of aggregated...
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Role of epithelial splicing regulatory protein 1 in cancer progression
As aberrant alternative splicing by either dysregulation or mutations of splicing factors contributes to cancer initiation and progression, splicing...
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Identification of CNS compatible small molecules as glycogen synthase kinase-3β (GSK-3β) inhibitors through structure-based virtual screening
Alzheimer’s Disease (AD) is one of the significant diseases of the aging population and affects Central Nervous System dominantly....
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Host-Directed Antiviral Therapy
Most of the antiviral drugs developed so far have been specifically designed to target particular pathogens and their unique viral pathways. However,...
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Inference of kinase-signaling networks in human myeloid cell line models by Phosphoproteomics using kinase activity enrichment analysis (KAEA)
BackgroundDespite the introduction of targeted therapies, most patients with myeloid malignancies will not be cured and progress. Genomics is useful...
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The nexus between RNA-binding proteins and their effectors
RNA-binding proteins (RBPs) regulate essentially every event in the lifetime of an RNA molecule, from its production to its destruction. Whereas much...
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The m6A reader IGF2BP2 promotes esophageal cell carcinoma progression by enhancing EIF4A1 translation
Esophageal squamous cell carcinoma (ESCC) is one of most prevalent cancers worldwide, especially in China. Lacking in depth mechanism study,...
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Design, synthesis, and biological evaluation of chalcone-linked thiazole-imidazopyridine derivatives as anticancer agents
A novel library of chalcone linked thiazole-imidazopyridine ( 12a–j ) derivatives were designed, synthesized, and their structures were characterized...
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Targeting influenza A virus by splicing inhibitor herboxidiene reveals the importance of subtype-specific signatures around splice sites
BackgroundThe association between M segment splicing and pathogenicity remains ambiguous in human influenza A viruses. In this study, we aimed to...
