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A robust clustering strategy for stratification unveils unique patient subgroups in acutely decompensated cirrhosis
BackgroundPatient heterogeneity poses significant challenges for managing individuals and designing clinical trials, especially in complex diseases....
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Severe coagulopathy caused by cefminox sodium in a liver cirrhosis patient: a case report
Cefminox sodium is an antimicrobial agent with broad-spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Cefminox...
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Influence of cirrhosis on outcomes of patients with advanced intrahepatic cholangiocarcinoma receiving chemotherapy
BackgroundCirrhosis is a risk factor for intrahepatic cholangiocarcinoma (iCC). However, its exact prevalence is uncertain and its impact on the...
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Non-invasive biomarkers prognostic of decompensation events in NASH cirrhosis: a systematic literature review
Liver cirrhosis due to nonalcoholic steatohepatitis (NASH) is a life-threatening condition with increasing incidence world-wide. Although its...
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Mesenchymal stromal cells in hepatic fibrosis/cirrhosis: from pathogenesis to treatment
Hepatic fibrosis/cirrhosis is a significant health burden worldwide, resulting in liver failure or hepatocellular carcinoma (HCC) and accounting for...
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Biomarkers of Malnutrition in Cirrhosis
Malnutrition is highly prevalent in patients with cirrhosis and is associated with increased morbidity and mortality. As a modifiable risk factor,...
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Biomarkers of Malnutrition in Cirrhosis
Malnutrition is highly prevalent in patients with cirrhosis and is associated with increased morbidity and mortality. As a modifiable risk factor,...
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Recommendations for the safe use of direct oral anticoagulants in patients with cirrhosis based on a systematic review of pharmacokinetic, pharmacodynamic and safety data
PurposeThe popularity of direct oral anticoagulants (DOACs) is increasing among patients with cirrhosis. Cirrhosis has a major impact on the...
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Severity of Liver Cirrhosis Evaluated by Digital Subtraction Angiography Using Quantitative Color-Coding Analysis Before Transarterial Embolization
PurposeThis study examined whether the quantitative color-coding analysis (QCA) of two-dimensional digital subtraction angiography (DSA) can...
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A female of progressive familial intrahepatic cholestasis type 3 caused by heterozygous mutations of ABCB4 gene and her cirrhosis improved after treatment of ursodeoxycholic acid: a case report
BackgroundProgressive familial intrahepatic cholestasis (PFIC) is a group of rapidly progressive autosomal recessive disorders characterized by...
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Elevated serum neurofilament light chain levels are associated with hepatic encephalopathy in patients with cirrhosis
Increasing evidences implicate vital role of neuronal damage in the development of hepatic encephalopathy (HE). Neurofilament light chain (NfL) is...
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Accurate prediction of HCC risk after SVR in patients with hepatitis C cirrhosis based on longitudinal data
BackgroundMost existing predictive models of hepatocellular carcinoma (HCC) risk after sustained virologic response (SVR) are built on data collected...
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Norfloxacin prophylaxis effect on multidrug resistance in patients with cirrhosis and bacterial infections
It is unclear whether norfloxacin predisposes to infections by multidrug-resistant organisms (MDROs). We aimed to evaluate if patients with...
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Development and validation of a nomogram for assessing hepatocellular carcinoma risk after SVR in hepatitis C patients with advanced fibrosis and cirrhosis
BackgroundHepatitis C patients with advanced fibrosis or cirrhosis are at high risk of develo** hepatocellular carcinoma (HCC), even after...
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Closing spontaneous portosystemic shunts in cirrhosis: Does it make sense? Does it work? What does it take?
Spontaneous portosystemic shunts (SPSS) are an often neglected cause of hepatic encephalopathy associated with cirrhosis. Nowadays, SPSS are...
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Sarcopenia negatively affects postoperative short-term outcomes of patients with non-cirrhosis liver cancer
BackgroundLiterature review have shown that sarcopenia substantially alters the postoperative outcomes after liver resection for malignant tumors....
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Spatial metabolomics on liver cirrhosis to hepatocellular carcinoma progression
BackgroundHepatocellular carcinoma (HCC) is one of the deadliest cancers and is mainly developed from chronic liver diseases such as hepatitis-B...
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Integrative analysis of the gut microbiota and faecal and serum short-chain fatty acids and tryptophan metabolites in patients with cirrhosis and hepatic encephalopathy
ObjectiveThe purpose of this study was to describe the changes in the gut microbiome of patients with cirrhosis and hepatic encephalopathy (HE), as...
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The Influence of ESR2 Gene Polymorphisms on Susceptibility to Hepatitis B Virus-Related Chronic Hepatitis, Liver Cirrhosis, and Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) represents an estrogen-dependent tumor. The action of estrogen is regulated via estrogen receptor (ER). Polymorphisms...
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Loss of FOCAD, operating via the SKI messenger RNA surveillance pathway, causes a pediatric syndrome with liver cirrhosis
Cirrhosis is usually a late-onset and life-threatening disease characterized by fibrotic scarring and inflammation that disrupts liver architecture...
