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Research Models for Studying Chronic Wasting Disease
Chronic wasting disease (CWD) is a burgeoning epidemic prion disease of cervids. While its origins are mysterious, the disease was first described in...
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Large animal models for chronic wasting disease
Chronic wasting disease (CWD) is a fatal neurodegenerative prion disease of cervid species including deer, elk, moose and reindeer. The disease has...
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Generation of human chronic wasting disease in transgenic mice
Chronic wasting disease (CWD) is a cervid prion disease caused by the accumulation of an infectious misfolded conformer (PrP Sc ) of cellular prion...
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Distribution of Alleles of PRNP Gene Associated with Chronic Wasting Disease in Wild and Domesticated Reindeer Rangifer tarandus in Russia
AbstractChronic wasting disease (CWD) is a prion disease that affects cervids. Amino acid substitutions Ser138, Ser225, and 2M-129S-169M in prion...
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Assessing Lung Inflammation and Pathology in Preclinical Models of Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is an incurable disease that is a major cause of mortality and morbidity worldwide. Cigarette smoking is...
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Parkin deficiency exacerbates fasting-induced skeletal muscle wasting in mice
Parkinson’s Disease (PD) is a chronic and progressive neurodegenerative disease manifesting itself with tremors, muscle stiffness, bradykinesia,...
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Human Prion Disease Surveillance
Human prion diseases are characterized by rapid fatal neurodegeneration caused by pathologic prion proteins that are transmissible under specific...
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Gut microbial metabolites SCFAs and chronic kidney disease
The global incidence of Chronic Kidney Disease (CKD) is steadily escalating, with discernible linkage to the intricate terrain of intestinal...
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Mechanism for exercise-mediated prevention against muscle wasting on extensor digitorum longus muscle in Spontaneously Diabetic Torii fatty rats
We previously reported the significant increase in limb muscle strength and cross-sectional area of the type IIb muscle fibers in the extensor...
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Species Barriers in Prion Disease
Species barriers in prion diseases are defined by the difficulty that prions from one species have in triggering prion infection in a new species....
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Metabolic acidosis in chronic kidney disease: mere consequence or also culprit?
Metabolic acidosis is a frequent complication in non-transplant chronic kidney disease (CKD) and after kidney transplantation. It occurs when net...
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Transcriptome-based deep learning analysis identifies drug candidates targeting protein synthesis and autophagy for the treatment of muscle wasting disorder
Sarcopenia, the progressive decline in skeletal muscle mass and function, is observed in various conditions, including cancer and aging. The complex...
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Decreased thymic output predicts progression of chronic kidney disease
BackgroundChronic kidney disease (CKD) is age-related disease, and decreased renal function is associated with the premature aging of T cells and...
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New developments in prion disease research using genetically modified mouse models
While much of what we know about the general principles of protein-based information transfer derives from studies of experimentally adapted rodent...
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Energy Balance and Neuroendocrine-Immune Regulation in Chronic Inflammatory and Neoplastic Diseases: An Evolutionary Perspective
The central nervous and immune systems are often in competition for energy substrates. After infection or injury, energy expenditure typically...
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A computational musculoskeletal arm model for assessing muscle dysfunction in chronic obstructive pulmonary disease
Computational models have been used extensively to assess diseases and disabilities effects on musculoskeletal system dysfunction. In the current...
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Physical exercise as a modulator of the purinergic system in the control of sarcopenia in individuals with chronic kidney disease on hemodialysis
The word sarcopenia derives from the Greek terms “sarx” for meat and “penia” for loss, thus being used to define reductions in muscle mass, muscle...
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Creatine homeostasis and protein energy wasting in hemodialysis patients
Muscle wasting, low protein intake, hypoalbuminemia, low body mass, and chronic fatigue are prevalent in hemodialysis patients. Impaired creatine...
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Evaluating the safety and efficacy of daprodustat for anemia of chronic kidney disease: a meta-analysis of randomized clinical trials
PurposeAnemia of chronic kidney disease (CKD) has traditionally been treated with recombinant human erythropoietin (rhEPO). Recently, daprodustat, a...
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Screening of key genes in the pathogenesis of muscle atrophy in CKD-PEW children based on RNA sequencing
BackgroundIn children with CKD, Protein Energy Wasting (PEW) is common, which affects the outcome of children and is an important cause of poor...
