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Vascularized organoid-on-a-chip: design, imaging, and analysis
Vascularized organoid-on-a-chip (VOoC) models achieve substance exchange in deep layers of organoids and provide a more physiologically relevant...
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Engineered extracellular vesicle-encapsulated CHIP as novel nanotherapeutics for treatment of renal fibrosis
Renal interstitial fibrosis (RIF) is a fundamental pathological feature of chronic kidney disease (CKD). However, toxicity and poor renal enrichment...
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CHIP promotes CAD ubiquitination and degradation to suppress the proliferation and colony formation of glioblastoma cells
PurposeCancer cells are characterized as the uncontrolled proliferation, which demands high levels of nucleotides that are building blocks for DNA...
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Recent advances in cancer-on-a-chip tissue models to dissect the tumour microenvironment
Three-dimensional cancer-on-a-chip tissue models aim to replicate the key hallmarks of the tumour microenvironment and allow for the study of dynamic...
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Methods for ChIP-seq Normalization and Their Application for the Analysis of Regulatory Elements in Brain Cells
Chromatin immunoprecipitation followed by sequencing (ChIP-seq) has become one of the major tools to elucidate gene-expression regulation. Similar to...
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Functional integration of natural killer cells in a microfluidically perfused liver on-a-chip model
ObjectiveThe liver acts as an innate immunity-dominant organ and natural killer (NK) cells, are the main lymphocyte population in the human liver. NK...
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Design of a Liver-on-a-Chip
An organ-on-a-chip is a microscale rigid plate (therefore, called a chip) containing the specialized cells of a given tissue and a fluid line flowing...
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Advances and challenges in organ-on-chip technology: toward mimicking human physiology and disease in vitro
Organs-on-chips have been tissues or three-dimensional (3D) mini-organs that comprise numerous cell types and have been produced on microfluidic...
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Chromatin Immunoprecipitation Sequencing (ChIP-Seq) Assay in Food Allergy Research
Chromatin immunoprecipitation (ChIP) analysis followed by genome-wide sequencing represents the most efficient method for studying the complex...
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Development of a novel testis-on-a-chip that demonstrates reciprocal crosstalk between Sertoli and Leydig cells in testicular tissue
The reciprocal crosstalk between testicular Sertoli and Leydig cells plays a vital role in supporting germ cell development and maintaining...
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Kidney-on-a-Chip
The Kidney-on-a-chip field is proving to be exponential helpful technology with the ability to revolutionize disease diagnosis, drug toxicology, and...
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Vaginal microbiome-host interactions modeled in a human vagina-on-a-chip
BackgroundA dominance of non-iners Lactobacillus species in the vaginal microbiome is optimal and strongly associated with gynecological and...
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State-of-the-art liver disease research using liver-on-a-chip
To understand disease pathophysiologies, models that recapitulate human functions are necessary. In vitro models that consist of human cells are...
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RepEnTools: an automated repeat enrichment analysis package for ChIP-seq data reveals hUHRF1 Tandem-Tudor domain enrichment in young repeats
BackgroundRepeat elements (REs) play important roles for cell function in health and disease. However, RE enrichment analysis in short-read...
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The Chromatin Immunoprecipitation (ChIP) Protocol for African Turquoise Killifish
DNA-binding proteins and epigenetic modifications coordinate to regulate the spatiotemporal pattern of gene expression during development, and thus,...
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Heart-on-a-Chip
A heart-on-a-chip is a microfluidic device that mimics the structural and functional characteristics of the heart by culturing cardiomyocytes on a...
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Microfluidics-on-a-chip for designing celecoxib-based amorphous solid dispersions: when the process shapes the product
The fundamental idea underlying the use of amorphous solid dispersions (ASDs) is to make the most of the solubility advantage of the amorphous form...
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Liver-on-a-Chip
Hepatotoxicity preclinical experiments using animal models have many limitations such as time consuming, expensive, and mismatching cross-species...
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T3E: a tool for characterising the epigenetic profile of transposable elements using ChIP-seq data
BackgroundDespite the advent of Chromatin Immunoprecipitation Sequencing (ChIP-seq) having revolutionised our understanding of the mammalian genome’s...
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Phenotypic screening in Organ-on-a-Chip systems: a 1537 kinase inhibitor library screen on a 3D angiogenesis assay
Modern drug development increasingly requires comprehensive models that can be utilized in the earliest stages of compound and target discovery. Here...
