Search
Search Results
-
Modulation of Solid-State Chemical Stability of Gabapentin by Pyridinecarboxylic Acid
PurposeGabapentin (GBP) is an anticonvulsant drug with poor chemical stability that is particularly sensitive to heat and mechanical stress, which...
-
Chemical Biology of Extracellular Vesicles
During the initial phases of extracellular vesicle (EV) research, researchers faced many obstacles, including a lack of standard methods for the...
-
Positive allosteric mGluR2 modulation with BINA alleviates dyskinesia and psychosis-like behaviours in the MPTP-lesioned marmoset
There is mounting evidence that positive allosteric modulation of metabotropic glutamate type 2 receptors (mGluR 2 ) is an efficacious approach to...
-
Cutaneous melanoma and purinergic modulation by phenolic compounds
Cutaneous melanoma is a complex pathology that still has only treatments that lack efficiency and offer many adverse effects. Due to this scenario...
-
Modulation of inflammatory mediators involved in the antinociceptive and anti-inflammatory effects of a new thioamide derivative: thiocyanoacetamide
Inflammatory pain is part of the body’s defense mechanism and plays an important role in the healing process. Although some drugs are efficient and...
-
Deficiency of UCHL1 results in insufficient decidualization accompanied by impaired dNK modulation and eventually miscarriage
BackgroundMiscarriage is a frustrating complication of pregnancy that is common among women of reproductive age. Insufficient decidualization which...
-
Genetic and Pharmacological Modulation of P75 Neurotrophin Receptor Attenuate Brain Damage After Ischemic Stroke in Mice
The precursor nerve growth factor (ProNGF) and its receptor p75 neurotrophin receptor (p75 NTR ) are upregulated in several brain diseases, including...
-
Role of Synbiotics on Modulation of Inflammation
The gastrointestinal (GI) microbiota benefits from the addition of probiotics, prebiotics, or synbiotics to the human diet. The human GI is colonized...
-
Probing Dynamic Behavior of Chemical Enhancers Passing In and Out of the Stratum Corneum and Modulation by Biodegradable Enhancer
Chemical enhancers (CEs) decreased the barrier of the stratum corneum (SC) to enhance drug permeation. This was a “dynamic” behavior, which involved...
-
Modulation of Pyruvate Export and Extracellular Pyruvate Concentration in Primary Astrocyte Cultures
Astrocyte-derived pyruvate is considered to have neuroprotective functions. In order to investigate the processes that are involved in astrocytic...
-
Analysis of the Immune Response by Standardized Whole-Blood Stimulation with Metabolism Modulation
The immune system defends the body from infection and plays a vital role in a wide range of health conditions. Metabolism affects a series of...
-
Approaches to Gene Modulation Therapy for ALS
Amyotrophic lateral sclerosis (ALS) is a devastating motor neuron disease for which there is currently no robust therapy. Recent progress in...
-
Beneficial role of capsaicin through modulation of mitochondrial functions in MPTP-injected mice
Capsaicin is one of the major phenolic components present in red chili and is responsible for its aromatic and spicy flavor. Capsaicin has an...
-
Inhibition for gain modulation in the motor system
Signatures of inhibition within the cortico-spinal pathway are frequently observed during action preparation in humans. Popular theoretical and...
-
p75 neurotrophin receptor modulation in mild to moderate Alzheimer disease: a randomized, placebo-controlled phase 2a trial
p75 neurotrophin receptor (p75 NTR ) signaling pathways substantially overlap with degenerative networks active in Alzheimer disease (AD). Modulation...
-
Modeling of the effect of cerebrospinal fluid flow modulation on locally delivered drugs in the brain
Cerebrospinal fluid (CSF) plays a vital role in maintaining brain homeostasis and recent research has focused on elucidating the role that convective...
-
Modulation of synaptic transmission through O-GlcNAcylation
O-GlcNAcylation is a posttranslational modification where N-acetylglucosamine (O-GlcNAc) is attached and detached from a serine/threonine position by...
-
Defensive and Emotional Behavior Modulation by Serotonin in the Periaqueductal Gray
Serotonin 5-hydroxytryptamine (5-HT) is a key neurotransmitter for the modulation and/or regulation of numerous physiological processes and...
-
Insights into the Modulation of Immune Response, Chemistry, and Mechanisms of Action of Immunomodulatory Phytomolecules
Modulators are defined as substances of different chemical natures that act together or in an antagonistic manner to initiate, maintain, reduce, and...
-
Effects of Transcranial Direct Current Stimulation (t-DCS) of the Cerebellum on Pain Perception and Endogenous Pain Modulation: a Randomized, Monocentric, Double-Blind, Sham-Controlled Crossover Study
Accumulating evidence demonstrates a role of the cerebellum in nociception. Some studies suggest that this is mediated via endogenous pain...
