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Cellular and clinical impact of protein phosphatase enzyme epigenetic silencing in multiple cancer tissues
BackgroundProtein Phosphatase Enzymes (PPE) and protein kinases simultaneously control phosphorylation mechanisms that tightly regulate intracellular...
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Cellular Interactions Network in Cancer: Integrative Disease Models
Integromics is necessitated as the complex diseases require to collate the integrated analysis expression, variation, and regulation of genes...
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Rapid fluctuations in functional connectivity of cortical networks encode spontaneous behavior
Experimental work across species has demonstrated that spontaneously generated behaviors are robustly coupled to variations in neural activity within...
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Cellular Senescence-Related Long Non-coding RNA Signatures Predict Prognosis in Juvenile Osteosarcoma
Osteosarcoma is the most common malignant bone tumor and is frequently diagnosed in juvenile. Cellular senescence is a fundamental hallmark of...
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Targeting protein interaction networks in mitochondrial dynamics for neurodegenerative diseases
Mitochondria, the powerhouse of eukaryotic cells, are the central organelle controlling energy metabolism and apoptosis. Based on metabolic needs,...
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The role of cellular senescence in neurodegenerative diseases
Increasing evidence has revealed that cellular senescence drives NDs, including Alzheimer’s disease (AD) and Parkinson’s disease. Different senescent...
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Brain Tumor Networks in Diffuse Glioma
Diffuse gliomas are primary brain tumors associated with a poor prognosis. Cellular and molecular mechanisms driving the invasive growth patterns and...
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Identification of diagnostic markers related to inflammatory response and cellular senescence in endometriosis using machine learning and in vitro experiment
ObjectiveTo understand the association between chronic inflammation, cellular senescence, and immunological infiltration in endometriosis.
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Biphasic Cholinergic Modulation of Reverberatory Activity in Neuronal Networks
Acetylcholine (ACh) is an important neuromodulator in various cognitive functions. However, it is unclear how ACh influences neural circuit dynamics...
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The impact of Plasmodium-driven immunoregulatory networks on immunity to malaria
Malaria, caused by infection with Plasmodium parasites, drives multiple regulatory responses across the immune landscape. These regulatory responses...
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Molecular and Cellular Mechanisms of the Restorative Effects of Sleep
This article discusses current concepts of the role of sleep in cellular energy metabolism, the processes of neuroplasticity, and cleansing of the...
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Cellular Interactions Networking in Interactive Models of Diseases
Integromics is necessitated as the complex diseases require to collate the integrated analysis expression, variation, and regulation of genes...
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Estimates of the permeability of extra-cellular pathways through the astrocyte endfoot sheath
BackgroundAstrocyte endfoot processes are believed to cover all micro-vessels in the brain cortex and may play a significant role in fluid and...
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Cellular Interactions Network in Cancer: Integrative Disease Models
Integromics is necessitated as the complex diseases require to collate the integrated analysis expression, variation, and regulation of genes...
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Cellular Stress, Survival Mechanism and Adaptation
At the cellular level, stress can be defined as an array of processes that get sparked as a result of an external stimulus, thereby leading to acute...
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Single-nucleus multi-omic profiling of human placental syncytiotrophoblasts identifies cellular trajectories during pregnancy
The human placenta has a vital role in ensuring a successful pregnancy. Despite the growing body of knowledge about its cellular compositions and...
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An atlas of cell-type-specific interactome networks across 44 human tumor types
BackgroundBiological processes are controlled by groups of genes acting in concert. Investigating gene–gene interactions within different cell types...
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COVID-19 and cellular senescence
The clinical severity of coronavirus disease 2019 (COVID-19) is largely determined by host factors. Recent advances point to cellular senescence, an...
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Map** the cellular response to electron transport chain inhibitors reveals selective signaling networks triggered by mitochondrial perturbation
Mitochondrial perturbation is a key event in chemical-induced organ toxicities that is incompletely understood. Here, we studied how electron...
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The concept of resilience to Alzheimer’s Disease: current definitions and cellular and molecular mechanisms
Some individuals are able to maintain their cognitive abilities despite the presence of significant Alzheimer’s Disease (AD) neuropathological...
