Search
Search Results
-
Prognostic value of circulating tumor cells detected with the CellSearch system in esophageal cancer patients: a systematic review and meta-analysis
BackgroundEsophageal carcinoma (EC) is the seventh-most prevalent tumor in the world, which is still one of the primary causes of tumor-related...
-
Circulating Tumor Cells (CTC) and Tumor-Derived Extracellular Vesicles (tdEV)
The observation that increasing circulating tumor cell (CTC) and tumor-derived extracellular vesicle (tdEV) load is directly related to worse...
-
Comparative analysis of EpCAM high-expressing and low-expressing circulating tumour cells with regard to their clonal relationship and clinical value
BackgroundCirculating tumour cells (CTCs) are mainly enriched based on the epithelial cell adhesion molecule (EpCAM). Although it was shown that an...
-
Shallow WGS of individual CTCs identifies actionable targets for informing treatment decisions in metastatic breast cancer
BackgroundWe report copy-number profiling by low-pass WGS (LP-WGS) in individual circulating tumour cells (CTCs) for guiding treatment in patients...
-
Prostein expression on circulating tumor cells as a prognostic marker in metastatic castration-resistant prostate cancer
BackgroundIdentification of emerging molecular biomarkers on circulating tumor cells (CTCs) represents an attractive feature of liquid biopsy that...
-
EMT-independent detection of circulating tumor cells in human blood samples and pre-clinical mouse models of metastasis
Circulating tumor cells (CTCs) present an opportunity to detect/monitor metastasis throughout disease progression. The CellSearch® is currently the...
-
Circulating tumor cells detected in follow-up predict survival outcomes in tri-modality management of advanced non-metastatic esophageal cancer: a secondary analysis of the QUINTETT randomized trial
BackgroundOur aim was to establish if presence of circulating tumor cells (CTCs) predicted worse outcome in patients with non-metastatic esophageal...
-
Tumor-agnostic ctDNA levels by mFAST-SeqS in first-line HR-positive, HER2 negative metastatic breast cancer patients as a biomarker for survival
This prospective cohort study reports aneuploidy score by mFast-SeqS as a strong prognostic marker in MBC patients. mFAST-SeqS is an affordable and...
-
Circulating tumour cells are associated with histopathological growth patterns of colorectal cancer liver metastases
Histopathological Growth Patterns (HGPs) have prognostic and predictive value in patients with Colorectal Liver Metastases (CRLM). This study...
-
Ultra-sensitive CTC-based liquid biopsy for pancreatic cancer enabled by large blood volume analysis
The limited sensitivity of circulating tumor cell (CTC) detection in pancreatic adenocarcinoma (PDAC) stems from their extremely low concentration in...
-
CTCs in Early Breast Cancer
In the last decades, treatment options for breast cancer patients improved rapidly, leading to a more personalized treatment approach. At the moment,...
-
Circulating tumour cells in gastrointestinal cancers: food for thought?
Gastrointestinal (GI) cancers account for 35% of cancer-related deaths, predominantly due to their ability to spread and generate drug-tolerant...
-
Leukapheresis increases circulating tumour cell yield in non-small cell lung cancer, counts related to tumour response and survival
BackgroundCirculating tumour cells (CTCs) can be used to monitor cancer longitudinally, but their use in non-small cell lung cancer (NSCLC) is...
-
Circulating Tumor Cells in Men Treated for Prostate Cancer
Despite the advancements in prostate cancer treatments, a significant proportion of men with higher risk features (approximately 25-50%) ultimately...
-
Circulating tumour cells and cell-free DNA as a prognostic factor in metastatic colorectal cancer: the OMITERC prospective study
BackgroundWithin the OMITERC prospective study (OMIcs application from solid to liquid biopsy for a personalised ThERapy of Cancer), we explored the...
-
Circulating tumor cells and palbociclib treatment in patients with ER-positive, HER2-negative advanced breast cancer: results from a translational sub-study of the TREnd trial
BackgroundCirculating tumor cells (CTCs) are prognostic in patients with advanced breast cancer (ABC). However, no data exist about their use in...
-
CTC-Based Liquid Biopsies and Diagnostic Leukapheresis
Circulating tumor cells (CTCs) appear as ideal tissue surrogate to inform on molecular characteristics of systemic cancer for rational therapeutic...
-
Clinical Perspectives in the Use of Liquid Biopsy in Metastatic Breast Cancer
Precision medicine aims to improve healthcare by identifying subsets of patients that are more likely to benefit from specific treatment strategies....
-
Biophysical Properties and Isolation of Circulating Tumor Cells
Circulating tumor cells (CTCs) are tumor cells that have entered the bloodstream. Although the vast majority do not survive the numerous stressors in...
-
Prognostic value of circulating tumor cells associated with white blood cells in solid cancer: a systematic review and meta-analysis of 1471 patients with solid tumors
BackgroundThe clinical relevance of circulating tumor cell-white blood cell (CTC-WBC) clusters in cancer prognosis is a subject of ongoing debate....
