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  1. Genomic view of the origins of cell-mediated immunity

    NKp30 is an activating natural killer cell receptor (NKR) with a single-exon variable (VJ)–type immunoglobulin superfamily (IgSF) domain. Such...

    Morgan E. Janes, Allison Kinlein, ... Yuko Ohta in Immunogenetics
    Article 22 September 2023

  2. Regnase-1 downregulation promotes pancreatic cancer through myeloid-derived suppressor cell-mediated evasion of anticancer immunity

    Background

    Pancreatitis is known to be an important risk factor for pancreatic ductal adenocarcinoma (PDAC). However, the exact molecular mechanisms...

    Junya Okabe, Takahiro Kodama, ... Tetsuo Takehara in Journal of Experimental & Clinical Cancer Research
    Article Open access 09 October 2023

  3. Self-amplifying mRNA seasonal influenza vaccines elicit mouse neutralizing antibody and cell-mediated immunity and protect ferrets

    Currently licensed influenza vaccines focus immune responses on viral hemagglutinin (HA), while the other major surface glycoprotein neuraminidase...

    Michael Cheung, Cheng Chang, ... Yingxia Wen in npj Vaccines
    Article Open access 04 October 2023

  4. Cell Mediated Immunity

    T cell function in adaptive immunity involves effector TH cells which provide cytokine help to B cells for antibody production against T-dependent...
    Tobili Y. Sam-Yellowe in Immunology: Overview and Laboratory Manual
    Chapter 2021

  5. Identification of genetic mechanisms underlying lipid metabolism-mediated tumor immunity in head and neck squamous cell carcinoma

    Objective

    To identify the genetic mechanisms underlying lipid metabolism-mediated tumor immunity in head and neck squamous carcinoma (HNSC).

    ...
    Shaokun Liu, Shuning Wang, Zhenlin Wang in BMC Medical Genomics
    Article Open access 20 May 2023

  6. Gasdermin E benefits CD8+T cell mediated anti-immunity through mitochondrial damage to activate cGAS-STING-interferonβ axis in colorectal cancer

    Background

    Pyroptosis belongs to a unique type of programmed cell death among which GSDME is reported to exert anti-tumor immunity. However, the...

    Bixian Luo, Shun Zhang, ... Mingliang Wang in Biomarker Research
    Article Open access 09 June 2024

  7. A Conceptual Framework for Inducing T Cell-Mediated Immunity Against Glioblastoma

    Glioblastoma is a highly aggressive brain tumor with limited treatment options. Several major challenges have limited the development of novel...

    Sascha Marx, Anze Godicelj, Kai W. Wucherpfennig in Seminars in Immunopathology
    Article 03 May 2022

  8. Cell surface ATP synthase-released H+ and ATP play key roles in cocoa butter intake-mediated regulation of gut immunity through releases of cytokines in rat

    Proper food intake is important for maintaining good health in humans. Chocolate is known to exert anti-inflammatory effects; however, the mechanisms...

    Nariaki Arai, Ryo Kajihara, ... Toshio Ohhashi in Pflügers Archiv - European Journal of Physiology
    Article 01 June 2023

  9. N6-methyladenosine regulator YTHDF1 represses the CD8 + T cell-mediated antitumor immunity and ferroptosis in prostate cancer via m6A/PD-L1 manner

    Increasing data and literature have illustrated that tumor immune escape represents a major source of tumor formation and recrudesce. Besides, novel...

    Yibing Wang, Peng **, **a Wang in Apoptosis
    Article 12 September 2023

  10. Dishevelled 2 regulates cancer cell proliferation and T cell mediated immunity in HER2-positive breast cancer

    Background

    Dishevelled paralogs (DVL1, 2, 3) are key mediators of Wnt pathway playing a role in constitutive oncogenic signaling influencing the tumor...

    Fahmida Rasha, Geetha Priya Boligala, ... Rakhshanda Layeequr Rahman in BMC Cancer
    Article Open access 21 February 2023

  11. Induction of T-helper-17-cell-mediated anti-tumour immunity by pathogen-mimicking polymer nanoparticles

    The effectivity of cancer immunotherapies is hindered by immunosuppressive tumour microenvironments that are poorly infiltrated by effector T cells...

    Se** Son, Jutaek Nam, ... James J. Moon in Nature Biomedical Engineering
    Article 23 December 2022

  12. Tumor necroptosis-mediated shedding of cell surface proteins promotes metastasis of breast cancer by suppressing anti-tumor immunity

    Necroptosis is a form of regulated necrosis and is executed by MLKL when MLKL is engaged in triggering the rupture of cell plasma membrane. MLKL...

    Zhaoshan Liu, Swati Choksi, ... Zheng-gang Liu in Breast Cancer Research
    Article Open access 26 January 2023

  13. ZG16 promotes T-cell mediated immunity through direct binding to PD-L1 in colon cancer

    Immunotherapy using programmed cell death 1 (PD1) inhibitors has shown great efficacy in colorectal cancer patients harboring...

    Hui Meng, Wu Yao, ... Mingzhi Zhang in Biomarker Research
    Article Open access 13 July 2022

  14. Antibody-mediated delivery of viral epitopes to redirect EBV-specific CD8+ T-cell immunity towards cancer cells

    Antibody-mediated delivery of immunogenic epitopes to redirect virus-specific CD8 + T-cells towards cancer cells is an emerging and promising new...

    Willemijn van der Wulp, Dennis F. G. Remst, ... Mirjam H. M. Heemskerk in Cancer Gene Therapy
    Article Open access 09 November 2023

  16. Immunity

    The term immunity is derived from the Latin word “immunis” (exempt), which originally referred to the protection from legal prosecution offered to...
    Subhash Chandra Parija in Textbook of Microbiology and Immunology
    Chapter 2023

  17. Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) in Cancer

    Antibody-dependet cell mediated cytotoxicity is a well known strategy to kill dangerous cells. Some antibody have the potential to bind IgG Fc...
    Matteo Paccagnella, Andrea Abbona, ... Ornella Garrone in Handbook of Cancer and Immunology
    Living reference work entry 2023

  18. The Use of Apheresis in Personalized Cell-Mediated Treatment of Prostate Cancer

    Beside a supportive therapy of deficient blood component(s) by transfusions, hemotherapy involves the use of apheresis procedures due to plasma or...
    Bela Balint, Mirjana Pavlovic, Milena Todorovic in Prostate Cancer
    Chapter 2024

  19. Author Correction: CIS is a potent checkpoint in NK cell–mediated tumor immunity

    Rebecca B. Delconte, Tatiana B. Kolesnik, ... Nicholas D. Huntington in Nature Immunology
    Article 12 December 2023

  20. Immunity, Immunity, Immunity

    Immunity is critical for survival from all infectious pathogens, including viruses. The three types of immunity (intrinsic, innate, and adaptive)...
    Van G. Wilson in Viruses: Intimate Invaders
    Chapter 2022
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