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Autophagy in Stem Cell Maintenance and Differentiation
AutophagyAutophagy is one of the intracellular machinery for maintaining organelle as well as physiological homeostasis in cells by clearance of...
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Autophagy in Stem Cell Maintenance and Differentiation
This book covers a wide range of topics that illustrate the various functions of autophagy in stem cells and offers insights on the mechanisms by...
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Autophagy in Cancer Metastasis
During cancerCancer development, tumour cells are exposed to various intrinsic and extrinsic stresses such as nutrient deficiency, lack of oxygen,...
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Autophagy in Mesenchymal Stem Cell-Based Therapy
Mesenchymal stem cellsMesenchymal stem cells (MSC)" (MSCs) are adult stem cells which are, due to their huge differentiation potential, potent...
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Autophagy in Muscle Stem Cells
Muscle stem cellsMuscle stem cell, also known as satellite cellsSatellite cell, are responsible for the regenerative capacity of adult muscle tissue...
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Regulation of autophagy by perilysosomal calcium: a new player in β-cell lipotoxicity
Autophagy is an essential quality control mechanism for maintaining organellar functions in eukaryotic cells. Defective autophagy in pancreatic beta...
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Periodontopathogen-Related Cell Autophagy—A Double-Edged Sword
The periodontium is a highly organized ecosystem, and the imbalance between oral microorganisms and host defense leads to periodontal diseases. The...
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Interplay Between Zika Virus-Induced Autophagy and Neural Stem Cell Fate Determination
The Zika virus (ZIKV) outbreaks and its co-relation with microcephaly have become a global health concern. It is primarily transmitted by a mosquito,...
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TBC1D5 reverses the capability of HIF-2α in tumor progression and lipid metabolism in clear cell renal cell carcinoma by regulating the autophagy
BackgroundClear cell renal cell carcinoma (ccRCC) is known for abnormal lipid metabolism and widespread activation of HIF-2α. Recently, the...
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Traumatic brain injury heterogeneity affects cell death and autophagy
Traumatic brain injury (TBI) mechanism and severity are heterogenous clinically, resulting in a multitude of physical, cognitive, and behavioral...
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Transcription factor EB-mediated autophagy affects cell migration and inhibits apoptosis to promote endometriosis
Autophagy has emerged as an important process of cell metabolism. With continuous in-depth research on autophagy, TFEB has been a key transcription...
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Autophagy Plays a Dual Role in Drug Resistance
Autophagy is a crucial mechanism that maintains the balance of cellular homeostasis by removing faulty or unneeded proteins as well as damaged or...
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Autophagy and autophagy signaling in Epilepsy: possible role of autophagy activator
Autophagy is an explicit cellular process to deliver dissimilar cytoplasmic misfolded proteins, lipids and damaged organelles to the lysosomes for...
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Autophagy in the Intestinal Stem Cells
Intestinal epithelial cells that are exposed to damage caused by the contents of the lumen die, and therefore a continuous and rapid turnover takes...
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Autophagy and nuclear morphometry are associated with histopathologic features in esophageal squamous cell carcinoma
AbstractLess than 15% of patients with esophageal squamous cell carcinoma (ESCC) survive 5 years after diagnosis. A better understanding of the...
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Methylated MFGE8 Promotes Early Brain Injury After Subarachnoid Hemorrhage and Inhibiting Autophagy of Nerve Cell
BackgroundSpontaneous subarachnoid hemorrhage (SAH) is a relatively common clinical hemorrhagic stroke crisis. The important role of early brain...
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Cell Cycle Analysis of ER Stress and Autophagy
Autophagy and ER stress are most often studied employing a Western blotting approach to the measurement of autophagy by LC3B upregulation and the ER...
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Autophagy as a Biomarker of Cytotoxicity
Since autophagy is involved in both cytoprotective and cytostatic/cytotoxic pathways depending on the types of stressor and culture conditions,...
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NEK2 contributes to radioresistance in esophageal squamous cell carcinoma by inducing protective autophagy via regulating TRIM21
BackgroundRadiotherapy (RT) has been identified as a vital treatment for esophageal squamous cell carcinoma (ESCC), while the development of...
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Assays for Monitoring Autophagy in Stem Cells
Macroautophagy (Autophagy hereafter) mediates degradation of cytoplasmic components and organelles via the lysosome in all types of cells including...