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T-cell infiltration and its regulatory mechanisms in cancers: insights at single-cell resolution
Tumor-infiltrating T cells recognize, attack, and clear tumor cells, playing a central role in antitumor immune response. However, certain immune...
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Natural Killer Cell Infiltration in Prostate Cancers Predict Improved Patient Outcomes
BackgroundNatural killer (NK) cells are non-antigen specific innate immune cells that can be redirected to targets of interest using multiple...
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Brain Immune Cell Infiltration and Serum Metabolomic Characteristics Reveal that Lauric Acid Promotes Immune Cell Infiltration in Brain and Streptococcus suis Meningitis in Mice
Although naturally Streptococcus suis serotype 2 (SS2) causes meningitis resulting in death or sequela of neurological symptoms in pigs and humans,...
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IGH repertoire analysis at scale: deciphering the complexity of B cell infiltration and migration in esophageal squamous cell carcinoma
Tumor-infiltrating B-lineage cells have become predictors of prognosis and immunotherapy responses in various cancers. However, limited knowledge...
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DCLK1 is Overexpressed and Associated with Immune Cell Infiltration in Hepatocellular Carcinoma
Recent research has shown that Doublecortin-like kinase 1 (DCLK1) is overexpressed in different types of cancer. It has recently been described as a...
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PSMC6 induces immune cell infiltration and inflammatory response to aggravate primary Sjögren’s syndrome
Increasing evidence suggests that immune cell infiltration is involved in primary Sjögren’s syndrome (pSS), while the underlying molecular mechanisms...
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cGAS-STING pathway expression correlates with genomic instability and immune cell infiltration in breast cancer
Genomic instability, as caused by oncogene-induced replication stress, can lead to the activation of inflammatory signaling, involving the cGAS-STING...
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HK3 stimulates immune cell infiltration to promote glioma deterioration
BackgroundGlioma is the most common and lethal type of brain tumor, and it is characterized by unfavorable prognosis and high recurrence rates. The...
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Identification and validation of biomarkers related to Th1 cell infiltration in neuropathic pain
Neuropathic pain (NP) is a widespread chronic pain with a prevalence of 6.9–10% in the general population, severely affecting patients’ physical and...
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Elk1 enhances inflammatory cell infiltration and exacerbates acute lung injury/acute respiratory distress syndrome by suppressing Fcgr2b transcription
ObjectiveAcute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are associated with significant mortality rates. The role of Fcgr2b...
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The Role of Immunocyte Infiltration Regulatory Network Based on hdWGCNA and Single-Cell Bioinformatics Analysis in Intervertebral Disc Degeneration
Immune infiltration plays a crucial role in intervertebral disc degeneration (IDD). In this study, we explored the immune microenvironment of IDD...
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Pharmacologic inhibition of IL11/STAT3 signaling increases MHC-I expression and T cell infiltration
BackgroundRecent studies have discovered an emerging role of IL11 in various colitis-associated cancers, suggesting that IL11 mainly promotes tumor...
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KNSTRN Is a Prognostic Biomarker That Is Correlated with Immune Infiltration in Breast Cancer and Promotes Cell Cycle and Proliferation
Kinetochore-localized astrin/SPAG5-binding protein (KNSTRN) promotes the progression of bladder cancer and lung adenocarcinoma. However, its...
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ANXA1 is identified as a key gene associated with high risk and T cell infiltration in primary sclerosing cholangitis
BackgroundPrimary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease, with unclear pathogenesis. Although immune disorders,...
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KIF2C is a prognostic biomarker associated with immune cell infiltration in breast cancer
BackgroundThe kinesin-13 family member 2C (KIF2C) is a versatile protein participating in many biological processes. KIF2C is frequently up-regulated...
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Identification of PANoptosis-related signature reveals immune infiltration characteristics and immunotherapy responses for renal cell carcinoma
PANoptosis is a specific type of inflammatory programmed cell death (PCD) modality that can be involved in three key modes of cellular programmed...
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Immune cell infiltration and inflammatory landscape in primary brain tumours
BackgroundPrimary malignant brain tumours are more than one-third of all brain tumours and despite the molecular investigation to identify cancer...
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SPP1 represents a therapeutic target that promotes the progression of oesophageal squamous cell carcinoma by driving M2 macrophage infiltration
BackgroundTumour-associated macrophages (TAMs) are an important component of the tumour microenvironment (TME). However, the crosstalk between...
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Increased infiltration of CD4+ T cell in the complement deficient lymphedema model
BackgroundLymphedema is an intractable disease that can be caused by injury to lymphatic vessels, such as by surgical treatments for cancer. It can...
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Single-cell and bulk RNA-seq unveils the immune infiltration landscape associated with cuproptosis in cerebral cavernous malformations
BackgroundCerebral cavernous malformations (CCMs) are vascular abnormalities associated with deregulated angiogenesis. Their pathogenesis and optimal...
