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Factor of time in dendritic cell (DC) maturation: short-term activation of DCs significantly improves type 1 cytokine production and T cell responses
Dendritic cells (DCs) have been intensively studied in correlation to tumor immunology and for the development DC-based cancer vaccines. Here, we...
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4-Octyl Itaconate Inhibits Proinflammatory Cytokine Production in Behcet’s Uveitis and Experimental Autoimmune Uveitis
4-octyl itaconate (4-OI) is an anti-inflammatory metabolite that activates the nuclear-factor-E2-related factor 2 (NRF2) signaling. In the current...
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Cytokine and chemokine map of peripheral specific immune cell subsets in Parkinson’s disease
Peripheral immune cells play a vital role in the development of Parkinson’s disease (PD). However, their cytokine and chemokine secretion functions...
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Whole Blood Dendritic Cell Cytokine Production Assay
This protocol outlines a method for the timely detection of intracellular cytokines produced by activated dendritic cells (DC) in human whole blood....
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Innate immunity, cytokine storm, and inflammatory cell death in COVID-19
The innate immune system serves as the first line of defense against invading pathogens; however, dysregulated innate immune responses can induce...
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Multi-target regulation of pro-inflammatory cytokine production by transcription factor Blimp-1
ObjectiveCytokine storm syndrome is a fatal condition related to infectious and autoimmune diseases. Here, we aim to investigate the regulatory...
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Melatonin as an immunomodulator in CD19-targeting CAR-T cell therapy: managing cytokine release syndrome
BackgroundChimeric antigen receptor CAR-T cell therapies have ushered in a new era of treatment for specific blood cancers, offering unparalleled...
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Introduction to Cytokine and Chemokine Networks
Cytokines are small-molecular-weight, proteinaceous, immunomodulating molecules that are crucial for controlling the growth and activity of blood and...
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Innate IRE1α-XBP1 activation by viral single-stranded RNA and its influence on lung cytokine production during SARS-CoV-2 pneumonia
The utilization of host-cell machinery during SARS-CoV-2 infection can overwhelm the protein-folding capacity of the endoplasmic reticulum and...
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Optimizing tumor-associated antigen-stimulated autologous dendritic cell and cytokine-induced killer cell coculture to enhance cytotoxicity for cancer immunotherapy in manufacturing
BackgroundDendritic Cell Cytokine-induced killer cell (DC-CIK) coculture treatment in cancer immunotherapy has been shown to be effective. However,...
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The nuclear cytokine IL-37a controls lethal cytokine storms primarily via IL-1R8-independent transcriptional upregulation of PPARγ
Cytokine storms are crucial in the development of various inflammatory diseases, including sepsis and autoimmune disorders. The immunosuppressive...
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An αvβ3 integrin checkpoint is critical for efficient TH2 cell cytokine polarization and potentiation of antigen-specific immunity
Naive CD4 + T lymphocytes initially undergo antigen-specific activation to promote a broad-spectrum response before adopting bespoke cytokine...
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Suppression of cytokine release syndrome during CAR-T-cell therapy via a subcutaneously injected interleukin-6-adsorbing hydrogel
The infusion of chimaeric antigen receptor (CAR) T cells can trigger the release of life-threatening supraphysiological levels of pro-inflammatory...
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Blockage of CXCR2 Activity Suppressed Inflammatory Cytokine Release and Ferroptosis in Rotenone-Induced SH-SY5Y Cell Model with PD-Like Lesions
AbstractParkinson’s disease (PD) is the most common neurodegenerative disease worldwide. Pesticides can cause neurotoxicity, which plays a vital role...
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In Vitro Cytokine Production by Dengue-Infected Human Monocyte-Derived Dendritic Cells
Despite many advances on the understanding of dengue pathogenesis in the last decades, some questions remained to be clarified. The virulence of the...
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Chemokine and Cytokine Network in Angiogenesis
Angiogenesis is a hallmark of cancer and has been the target of new therapies since last few years; however, it is a complex process and involves...
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Boosting cytotoxicity of adoptive allogeneic NK cell therapy with an oncolytic adenovirus encoding a human vIL-2 cytokine for the treatment of human ovarian cancer
Despite good results in the treatment of hematological malignancies, Natural killer (NK) cells have shown limited effectiveness in solid tumors, such...
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Anti-cytokine autoantibodies: mechanistic insights and disease associations
Anti-cytokine autoantibodies (ACAAs) are increasingly recognized as modulating disease severity in infection, inflammation and autoimmunity. By...
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Cytokine Production in Whole Blood Cells Culture of Patients with Alcohol Dependence and Autologous Plasma Oxidative Stress Markers
We studied spontaneous production of a spectrum of proinflammatory cytokines by cultured whole blood cells from men with alcohol dependence at the...