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Integrative approach using network pharmacology, bioinformatics, and experimental methods to explore the mechanism of cantharidin in treating colorectal cancer
Cantharidin, a terpenoid produced by blister beetles, has been used in traditional Chinese medicine to treat various ailments and cancers. However,...
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Cantharidin induces apoptosis of human triple negative breast cancer cells through mir-607-mediated downregulation of EGFR
BackgroundTriple negative breast cancer (TNBC) is a major subtype of breast cancer, with limited therapeutic drugs in clinical. Epidermal growth...
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Cantharidin and sodium fluoride attenuate the negative inotropic effects of carbachol in the isolated human atrium
Carbachol, an agonist at muscarinic receptors, exerts a negative inotropic effect in human atrium. Carbachol can activate protein phosphatases (PP1...
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Cantharidin increases the force of contraction and protein phosphorylation in isolated human atria
Cantharidin, an inhibitor of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A), is known to increase the force of contraction and shorten...
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Integrative analysis of the molecular signature of target genes involved in the antitumor effects of cantharidin on hepatocellular carcinoma
BackgroundCantharidin (CTD) is the active ingredient of Chinese medicine, which has been traditionally used in multiple cancers treatment, especially...
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The protective effect of L-glutamine against acute Cantharidin-induced Cardiotoxicity in the mice
BackgroundCantharidin (CTD) is a compound which have the potential to be exploited as an antitumor drug, and it has been demonstrated antitumor...
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A systematic study on the treatment of hepatitis B-related hepatocellular carcinoma with drugs based on bioinformatics and key target reverse network pharmacology and experimental verification
BackgroundChronic hepatitis B virus (HBV) infection is the major etiology of hepatocellular carcinoma (HCC). However, the mechanism of hepatitis...
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Norcantharidin toxicity profile: an in vivo murine study
Norcantharidin (NCTD) is the demethylated analog of cantharidin, with allegedly reduced toxicity. However, there is still limited information...
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Lipidomics reveals serum lipid metabolism disorders in CTD-induced liver injury
BackgroundCantharidin (CTD), the main toxic component of Mylabris , has been extensively used for tumor treatment in recent years. CTD-induced liver...
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Norcantharidin ameliorates the development of murine lupus via inhibiting the generation of IL-17 producing cells
Systemic lupus erythematosus (SLE) is a devastating autoimmune disorder associated with severe organ damage. The abnormality of T cell apoptosis is...
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Further investigations on the influence of protein phosphatases on the signaling of muscarinic receptors in the atria of mouse hearts
The vagal regulation of cardiac function involves acetylcholine (ACh) receptor activation followed by negative chronotropic and negative as well as...
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Bioassay-guided isolation of cantharidin from blister beetles and its anticancer activity through inhibition of epidermal growth factor receptor-mediated STAT3 and Akt pathways
Cantharidin is an active constituent of blister beetles (cantharides) which have traditionally been used for cancer treatment. Several studies have...
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Avian Toxins and Poisoning Mechanisms
All around the world, there are species of birds that have developed the ability to acquire toxic chemicals in their bodies making them less...
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Altering phosphorylation in cancer through PP2A modifiers
Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase integral to the regulation of many cellular processes. Due to the deregulation of...
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Protective and therapeutic effects of Scutellaria baicalensis and its main active ingredients baicalin and baicalein against natural toxicities and physical hazards: a review of mechanisms
ObjectivesScutellaria baicalensis (SB) has been traditionally used to combat a variety of conditions ranging from ischemic heart disease to cancer....
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Bioactive constituents of animal-derived traditional Chinese medicinal materials for breast cancer: opportunities and challenges
Breast cancer is globally the most common invasive cancer in women and remains one of the leading causes of cancer-related deaths. Surgery,...
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Microfluidic Manufacturing of Niosomes
The efficient delivery of therapeutic agents remains a formidable hurdle in the realm of medical applications, primarily due to issues such as...
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Heat Shock Factors in Protein Quality Control and Spermatogenesis
Proper regulation of cellular protein quality control is crucial for cellular health. It appears that the protein quality control machinery is...
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Autophagy Suppression Accelerates Apoptosis Induced by Norcantharidin in Cholangiocarcinoma
Norcantharidin is a cantharidin demethylated analog with antitumor effects in many tumors, including cholangiocarcinoma. Autophagy suppression is...
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The novel norcantharidin derivative DCZ5417 suppresses multiple myeloma progression by targeting the TRIP13–MAPK–YWHAE signaling pathway
BackgroundMultiple myeloma (MM), an incurable disease owing to drug resistance, requires safe and effective therapies. Norcantharidin (NCTD), an...
