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Entry of cannabidiol into the fetal, postnatal and adult rat brain
Cannabidiol is a major component of cannabis but without known psychoactive properties. A wide range of properties have been attributed to it, such...
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Dual-step pharmacological intervention for traumatic-like memories: implications from D-cycloserine and cannabidiol or clonidine in male and female rats
RationaleTherapeutic approaches to mitigating traumatic memories have often faced resistance. Exploring safe reconsolidation blockers, drugs capable...
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Role of the endocannabinoid system in fragile X syndrome: potential mechanisms for benefit from cannabidiol treatment
Multiple lines of evidence suggest a central role for the endocannabinoid system (ECS) in the neuronal development and cognitive function and in the...
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Prospective affirmative therapeutics of cannabidiol oil mitigates doxorubicin-induced abnormalities in kidney function, inflammation, and renal tissue changes
Nephropathy is the decline in kidney function. A promising treatment for numerous types of illness is using natural materials as natural chemical...
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High Concentrations of Cannabidiol Induce Neurotoxicity in Neurosphere Culture System
Recent studies have demonstrated that cannabinoids are potentially effective in the treatment of various neurological conditions, and cannabidiol...
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The Effectiveness and Safety of Cannabidiol in Non-seizure-related Indications: A Systematic Review of Published Randomized Clinical Trials
BackgroundLegislative changes have fueled the global availability of cannabis and cannabis-derived compounds, such as cannabidiol. Little is known...
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Comparative Pharmacokinetics of Commercially Available Cannabidiol Isolate, Broad-Spectrum, and Full-Spectrum Products
Background and ObjectivesA wide variety of products containing cannabidiol (CBD) are available on the commercial market. One of the most common...
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Quantitative summary on the human pharmacokinetic properties of cannabidiol to accelerate scientific clinical application of cannabis
Cannabidiol (CBD) is a non-psychoactive substance that exerts numerous pharmacological benefits, including anti-inflammatory and antioxidant...
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Effectiveness of cannabidiol (CBD) on histopathological changes and gene expression in hepatocellular carcinoma (HCC) model in male rats: the role of Hedgehog (Hh) signaling pathway
The third most prevalent malignancy to cause mortality is hepatocellular carcinoma (HCC). The Hedgehog (Hh) signaling pathway is activated by binding...
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Polycaprolactone microparticles for the subcutaneous administration of cannabidiol: in vitro and in vivo release
Cannabidiol (CBD) has become a highly attractive entity in therapeutics. However, its low aqueous solubility, instability and handling problems limit...
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Cannabidiol Exerts Sedative and Hypnotic Effects in Normal and Insomnia Model Mice Through Activation of 5-HT1A Receptor
Cannabis sativa has been used for improving sleep for long history. Cannabidiol (CBD) has drown much attention as a non-addictive psychoactive...
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Combining the potential of 3D printed buccal films and nanostructured lipid carriers for personalised cannabidiol delivery
Cannabidiol (CBD) has been recognized for its numerous therapeutic benefits, such as neuroprotection, anti-inflammatory effects, and...
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Effects of cannabidiol on fear conditioning in anxiety disorders: decreased threat expectation during retention, but no enhanced fear re-extinction
RationalePreclinical research suggests that pharmacologically elevating cannabinoid levels may attenuate fear memory expression and enhance fear...
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A randomized, controlled trial of ZYN002 cannabidiol transdermal gel in children and adolescents with fragile X syndrome (CONNECT-FX)
BackgroundFragile X syndrome (FXS) is associated with dysregulated endocannabinoid signaling and may therefore respond to cannabidiol therapy.
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Formulation Development and Evaluation of Cannabidiol Hot-Melt Extruded Solid Self-Emulsifying Drug Delivery System for Oral Applications
Cannabidiol (CBD) is a highly lipophilic compound with poor oral bioavailability, due to poor aqueous solubility and extensive pre-systemic...
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Tetrahydrocannabinol and cannabidiol medicines for chronic pain and mental health conditions
Combination tetrahydrocannabinol (THC)/cannabidiol (CBD) medicines or CBD-only medicines are prospective treatments for chronic pain, stress,...
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Effect of Cannabidiol in LPS-Induced Toxicity in Astrocytes: Possible Role for Cannabinoid Type-1 Receptors
Cerebral metabolic abnormalities are common in neurodegenerative diseases. Previous studies have shown that mitochondrial damage alters ATP...
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Knockdown siRNA Targeting GPR55 Reveals Significant Differences Between the Anti-inflammatory Actions of KLS-13019 and Cannabidiol
KLS-13019 was reported previously to reverse paclitaxel-induced mechanical allodynia in a mouse model of chemotherapy-induced peripheral neuropathy...
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Cannabidiol for the treatment of autism spectrum disorder: hope or hype?
RationaleAutism spectrum disorder (ASD) is defined as a group of neurodevelopmental disorders whose symptoms include impaired communication and...
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Autophagic Molecular Alterations in the Mouse Cerebellum Experimental Autoimmune Encephalomyelitis Model Following Treatment with Cannabidiol and Fluoxetine
The crosstalk between autophagy and apoptosis is one of the most important processes involved in the cell program death, and several mechanisms...
