Search
Search Results
-
Piezo2 Channel Upregulation is Involved in Mechanical Allodynia in CYP-Induced Cystitis Rats
Mechanical sensing Piezo2 channel in primary sensory neurons has been shown contribute to mechanical allodynia in somatic chronic pain conditions....
-
Application of fused-grid-based CYP-Template systems for genotoxic substances to understand the metabolisms
Understanding of metabolic processes is a key factor to evaluate biological effects of carcinogen and mutagens. Applicability of fused-grid Template*...
-
A self-microemulsion enhances oral absorption of docetaxel by inhibiting P-glycoprotein and CYP metabolism
Oral absorption of docetaxel was limited by drug efflux pump p-glycoprotein (P-gp) and cytochrome P450 enzyme (CYP 450). Therefore, co-loading agent...
-
Evaluation of Hydroxychloroquine as a Perpetrator on Cytochrome P450 (CYP) 3A and CYP2D6 Activity with Microdosed Probe Drugs in Healthy Volunteers
Background and ObjectiveAlthough polypharmacy is a particular challenge in daily rheumatological practice, clinical research on the effects of...
-
Prediction of CYP-mediated silybin A-losartan pharmacokinetic interactions using physiological based pharmacokinetic modeling
The concomitant use of herbal products and synthetic drugs necessitates the assessment of their interaction potentials. The herbal hepatoprotective...
-
-
A cocktail probe approach to evaluate the effect of hormones on the expression and activity of CYP enzymes in human hepatocytes with conditions simulating late stage of pregnancy
PurposePregnancy-mediated physiological and biochemical changes contribute to alterations in the pharmacokinetics of certain drugs. There is a...
-
Inter-individual variation in chlorpyrifos toxicokinetics characterized by physiologically based kinetic (PBK) and Monte Carlo simulation comparing human liver microsome and Supersome™ cytochromes P450 (CYP)-specific kinetic data as model input
The present study compares two approaches to evaluate the effects of inter-individual differences in the biotransformation of chlorpyrifos (CPF) on...
-
-
CYP-associated drug–drug interactions: A mission accomplished?
On the basis of official Finnish Medicines Authority (Fimea)-approved drug monographs, less than half of the approved small-molecule drugs between...
-
-
Inhibition and induction of CYP enzymes in humans: an update
The cytochrome P450 (CYP) enzyme family is the most important enzyme system catalyzing the phase 1 metabolism of pharmaceuticals and other...
-
Geneesmiddeleninteracties via cytochroom P450 (CYP)
Geneesmiddelen kunnen elkaars werking op farmacodynamische en farmacokinetische wijze beïnvloeden: in het eerste geval is er bijv. sprake van...
-
Differentiation of Cytochrome P450-Mediated from Non-CYP-Mediated Metabolism: Aldehyde Oxidase and Xanthine Oxidoreductase
Aldehyde oxidase and xanthine oxidoreductase are part of the molybdo-flavo family of enzymes. They have become increasingly relevant in drug...
-
Circadian Clock and CYP Metabolism
Cytochromes P450 (CYPs), a superfamily of hemoproteins, have monooxygenase activity and are involved in xenobiotic detoxification and lipid...
-
Circadian Clock and Non-CYP Phase I Metabolism
Circadian rhythms in drug metabolism by non-CYP phase I enzymes (i.e., MAOs) have been recognized since 1970s. The profound effects of the circadian...
-
Effect of N-acetylcysteine on hair follicle changes in mouse model of cyclophosphamide-induced alopecia: histological and biochemical study
Chemotherapy-induced alopecia (CIA) represents one of the most severe side effects of chemotherapy, which forces some patients to reject cancer...
-
S-warfarin limited sampling strategy with a population pharmacokinetic approach to estimate exposure and cytochrome P450 (CYP) 2C9 activity in healthy adults
PurposeS-warfarin is used to phenotype cytochrome P450 (CYP) 2C9 activity. This study evaluated S-warfarin limited sampling strategy with a...
-
-
The Use of Microdosing for In vivo Phenoty** of Cytochrome P450 Enzymes: Where Do We Stand? A Narrative Review
Cytochrome P450 (CYP) enzymes play a central role in the elimination of approximately 80% of all clinically used drugs. Differences in CYP enzyme...
