Search
Search Results
-
Emerging role of STING signalling in CNS injury: inflammation, autophagy, necroptosis, ferroptosis and pyroptosis
Stimulator of interferons genes (STING), which is crucial for the secretion of type I interferons and proinflammatory cytokines in response to...
-
The astrocyte-produced growth factor HB-EGF limits autoimmune CNS pathology
Central nervous system (CNS)-resident cells such as microglia, oligodendrocytes and astrocytes are gaining increasing attention in respect to their...
-
Suicide and Inflammation
Suicide is a leading cause of death worldwide. Although the neurobiological dysfunction underlying suicidal behavior remains unclear, recent work...
-
LXR agonism for CNS diseases: promises and challenges
The unfavorable prognosis of many neurological conditions could be attributed to limited tissue regeneration in central nervous system (CNS) and...
-
Metabolic response to CNS infection with flaviviruses
Flaviviruses are arthropod-borne RNA viruses found worldwide that, when introduced into the human body, cause diseases, including neuroinfections,...
-
Inflammation and Pain
Inflammation is the body’s natural response to injury or the infiltration of a foreign substance. The process is defined by five cardinal signs:...
-
The novel HS-mimetic, Tet-29, regulates immune cell trafficking across barriers of the CNS during inflammation
BackgroundDisruption of the extracellular matrix at the blood–brain barrier (BBB) underpins neuroinflammation in multiple sclerosis (MS). The...
-
Tumor inflammation-associated neurotoxicity
Cancer immunotherapies have unique toxicities. Establishment of grading scales and standardized grade-based treatment algorithms for toxicity...
-
Animal Inflammation-Based Models of Neuropsychiatric Disorders
Mounting evidence links psychiatric disorders to central and systemic inflammation. Experimental (animal) models of psychiatric disorders are...
-
Overview of Inflammation
Inflammation serves as a vital protective mechanism within the human body, contributing to the facilitation of the healing process. It can be...
-
PTSD, Immune System, and Inflammation
Posttraumatic stress disorder (PTSD) is a severe trauma and stress-related disorder associated with different somatic comorbidities, especially...
-
IL-12 sensing in neurons induces neuroprotective CNS tissue adaptation and attenuates neuroinflammation in mice
Interleukin-12 (IL-12) is a potent driver of type 1 immunity. Paradoxically, in autoimmune conditions, including of the CNS, IL-12 reduces...
-
Underlying Mechanism of Lysosomal Membrane Permeabilization in CNS Injury: A Literature Review
Lysosomes play a crucial role in various intracellular pathways as their final destination. Various stressors, whether mild or severe, can induce...
-
CNS-associated macrophages contribute to intracerebral aneurysm pathophysiology
Intracerebral aneurysms (IAs) are pathological dilatations of cerebral arteries whose rupture leads to subarachnoid hemorrhage, a significant cause...
-
Metabolic Regulation of Inflammation
Immune cells continuously guard the body through the bloodstream and disperse into various tissues where they are exposed to a variety of challenging...
-
Potential Roles of Nr4a3-Mediated Inflammation in Immunological and Neurological Diseases
As a protein of the orphan nuclear receptor Nr4a family, Nr4a3 has no identified natural ligands. However, its biological activity can be mediated by...
-
Inflammation Resolution Mediators: Future Prospects
Inflammation resolution is a complex system that involves a variety of lipid mediators, proteins, hormones, and gaseous mediators that act in a...
-
Impact of NQO1 dysregulation in CNS disorders
NAD(P)H Quinone Dehydrogenase 1 (NQO1) plays a pivotal role in the regulation of neuronal function and synaptic plasticity, cellular adaptation to...
-
Insulin-like growth factor-1 receptor controls the function of CNS-resident macrophages and their contribution to neuroinflammation
Signaling by insulin-like growth factor-1 (IGF-1) is essential for the development of the central nervous system (CNS) and regulates neuronal...
-
The Gut Microbiome and the Central Nervous System (CNS)
The presence of resident microbial species in the human gastrointestinal tract has been known for a long time. However, only recently have they been...