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Identification of founder and novel mutations that cause congenital insensitivity to pain (CIP) in palestinian patients
BackgroundCongenital insensitivity to pain (CIP) is a rare autosomal recessive disorder characterized primarily by an inability to perceive physical...
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Transformation of A1/A2 Astrocytes Participates in Brain Ischemic Tolerance Induced by Cerebral Ischemic Preconditioning via Inhibiting NDRG2
Cerebral ischemic preconditioning (CIP) has been shown to improve brain ischemic tolerance against subsequent lethal ischemia. Reactive astrocytes...
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STAT4-Mediated Klotho Up-Regulation Contributes to the Brain Ischemic Tolerance by Cerebral Ischemic Preconditioning via Inhibiting Neuronal Pyroptosis
Our previous study has proved that the Klotho up-regulation participated in cerebral ischemic preconditioning (CIP)-induced brain ischemic tolerance....
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Quantification of preexisting lung ground glass opacities on CT for predicting checkpoint inhibitor pneumonitis in advanced non-small cell lung cancer patients
BackgroundImmune checkpoint inhibitors (ICIs) can lead to life-threatening pneumonitis, and pre-existing interstitial lung abnormalities (ILAs) are a...
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Potential antivirulence activity of sub-inhibitory concentrations of ciprofloxacin against Proteus mirabilis isolates: an in-vitro and in-vivo study
BackgroundProteus mirabilis is a significant nosocomial pathogen that is frequently associated with a wide range of infections, necessitating...
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Indomethacin Combined with Ciprofloxacin Improves the Prognosis of Mice under Severe Traumatic Infection via the PI3K/Akt Pathway in Macrophages
The prevention and treatment strategies for traumatic infection often focus on the use of antibiotics, while eschew the combined treatment of the...
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Polymeric nanoparticles delivery circumvents bacterial resistance to ciprofloxacin
ObjectiveThe efficient inhibition of bacteria and their by-products from infected root canals is hampered by the limitations of traditional root...
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Clinical characteristics and therapeutic effects of checkpoint inhibitor-related pneumonitis in patients with non-small cell lung cancer
BackgroundWith the application of immune checkpoint inhibitors (ICIs) in cancer treatment, more and more attention has been paid to checkpoint...
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Klotho Upregulation via PPARÎł Contributes to the Induction of Brain Ischemic Tolerance by Cerebral Ischemic Preconditioning in Rats
Cerebral ischemic preconditioning (CIP)-induced brain ischemic tolerance protects neurons from subsequent lethal ischemic insult. However, the...
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Arula-7 powder improves diarrhea and intestinal epithelial tight junction function associated with its regulation of intestinal flora in calves infected with pathogenic Escherichia coli O1
BackgroundThe effects of Arula-7 powder (ASP) on diarrhea and intestinal barrier function associated with its regulation of intestinal microflora in...
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Radiographic features and prognosis of early- and late-onset non-small cell lung cancer immune checkpoint inhibitor-related pneumonitis
BackgroundImmunotherapy is becoming a standard of care for non-small cell lung cancer (NSCLC). Checkpoint inhibitor-associated pneumonia (CIP) is a...
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Fabrication of CuNPs Using Schiff Base Ligand and Their Catalytic Reduction of Pharmaceutical Drugs, Fluorescence Selective Detection of Cd2+, Antimicrobial, and Antioxidant Activities
Here, we have approached the synthesis of copper nanoparticles (CuNPs) Schiff base...
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Hepatobiliary Cancers: An Interdisciplinary Approach
Hepatobiliary cancers, including hepatocellular carcinoma and biliary tract cancers, have high rate of mortality and low survival rate.
The third...
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Cancer Treatment: An Interdisciplinary Approach
Cancer treatment is a challenging issue, while the treatment modalities have extended from traditional surgery, chemotherapy, and radiation therapy...
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Role of Cyclin-Dependent Kinase Inhibitors (CKIs) as a Prognostic Biomarker for Cancer
Prognostic biomarkers have drawn significant attention in recent decades as a dependable, low-cost tool for not only early cancer diagnosis and...
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Microwave-assisted Synthesis, Characterization, Photocatalytic Degradation of Antibiotics, and Fluorometric Selective Sensing Activity of g-C3N4 Supported CuO Composites
Herein, we have designed for the fabrication of a series of g-C 3 N 4 /CuO composite by using one-step microwave-assisted synthesis for the degradation...
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Gastrointestinal Cancers: An Interdisciplinary Approach
Gastrointestinal cancers are among the most prevalent malignancies worldwide, with high rate of global cancer incidence and cancer-related death....
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Cellular analysis of bronchoalveolar lavage fluid to narrow differential diagnosis of checkpoint inhibitor-related pneumonitis in metastatic melanoma
BackgroundThe diagnosis of check-point inhibitor-related pneumonitis (CIP) relies on radiological and clinical patterns which are not specific and...
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Molecular Determinants of Antibiotic Resistance in the Costa Rican Pseudomonas aeruginosa AG1 by a Multi-omics Approach: A Review of 10 Years of Study
Pseudomonas aeruginosa AG1 (PaeAG1) is a Costa Rican strain that was isolated in 2010 in a major Hospital. This strain has resistance to multiple...
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Cancer Research: An Interdisciplinary Approach
Cancer is a major public health concern and one of the leading causes of death. There is no simple solution for this complex disease, therefore...
