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Single-cell characterisation of tissue homing CD4 + and CD8 + T cell clones in immune-mediated refractory arthritis
BackgroundImmune-mediated arthritis is a group of autoinflammatory diseases, where the patient’s own immune system attacks and destroys synovial...
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Circulating memory PD-1+CD8+ T cells and PD-1+CD8+T/PD-1+CD4+T cell ratio predict response and outcome to immunotherapy in advanced gastric cancer patients
BackgroundLimited benefit population of immunotherapy makes it urgent to select effective biomarkers for screening appropriate treatment population....
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Neoantigen-specific stem cell memory-like CD4+ T cells mediate CD8+ T cell-dependent immunotherapy of MHC class II-negative solid tumors
CD4 + T cells play key roles in a range of immune responses, either as direct effectors or through accessory cells, including CD8 + T lymphocytes. In...
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Evaluating the immunologically “cold” tumor microenvironment after treatment with immune checkpoint inhibitors utilizing PET imaging of CD4 + and CD8 + T cells in breast cancer mouse models
BackgroundImmune-positron emission tomography (PET) imaging with tracers that target CD8 and granzyme B has shown promise in predicting the...
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Intratumoral dendritic cell–CD4+ T helper cell niches enable CD8+ T cell differentiation following PD-1 blockade in hepatocellular carcinoma
Despite no apparent defects in T cell priming and recruitment to tumors, a large subset of T cell rich tumors fail to respond to immune checkpoint...
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Phenotypic and Functional Characterization of Memory CD4+ and CD8+ T Cells After Antigenic Stimulation
The encounter of T cells with the antigen through the interaction of T cell receptors with peptides and major histocompatibility complex (MHC)...
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Comparative analysis of the DNA methylation landscape in CD4, CD8, and B memory lineages
BackgroundThere is considerable evidence that epigenetic mechanisms and DNA methylation are critical drivers of immune cell lineage differentiation...
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S1P/S1PR1 signaling differentially regulates the allogeneic response of CD4 and CD8 T cells by modulating mitochondrial fission
Graft-versus-host disease (GVHD) significantly contributes to patient morbidity and mortality after allogeneic hematopoietic cell transplantation...
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Posttranscriptional Events Orchestrate Immune Homeostasis of CD8+ T Cells
Maintaining immune homeostasis is instrumental for host health. Immune cells, such as T cells, are instrumental for the eradication of pathogenic...
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AMPKα2 promotes tumor immune escape by inducing CD8+ T-cell exhaustion and CD4+ Treg cell formation in liver hepatocellular carcinoma
BackgroundAdenosine monophosphate-activated protein kinase (AMPK) is associated with the development of liver hepatocellular carcinoma (LIHC)....
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CD4+ T cells produce IFN-I to license cDC1s for induction of cytotoxic T-cell activity in human tumors
CD4 + T cells can "help” or "license” conventional type 1 dendritic cells (cDC1s) to induce CD8 + cytotoxic T lymphocyte (CTL) anticancer responses, as...
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Human T lymphocytes at tumor sites
CD4 + and CD8 + T lymphocytes mediate most of the adaptive immune response against tumors. Naïve T lymphocytes specific for tumor antigens are primed...
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CD40 ligand stimulation affects the number and memory phenotypes of human peripheral CD8+ T cells
BackgroundCD40L is primarily expressed on activated CD4 + T cells and binds to CD40 which is expressed by various cells including dendritic cells,...
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Thymoquinone modifies CD4+:CD8+ ratio without affecting tumor necrosis factor-α and interleukin-1β levels in Wallerian degeneration crush injury rat model
Wallerian degeneration following nerve injury not only suppresses CD4+ T-cell responses but also promotes pro-inflammatory immunological responses...
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CD8+ T cell-based cancer immunotherapy
The immune system in humans is a defense department against both exogenous and endogenous hazards, where CD8 + T cells play a crucial role in opposing...
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Soluble lymphocyte activation gene-3 (sLAG3) and CD4/CD8 ratio dynamics as predictive biomarkers in patients undergoing immune checkpoint blockade for solid malignancies
BackgroundThe search for biomarkers to identify suitable candidates for immune checkpoint inhibitor (ICI) therapy remains ongoing. We evaluate how...
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Persistence and enrichment of dominant T cell clonotypes in expanded tumor-infiltrating lymphocytes of breast cancer
BackgroundAdoptive cell therapy using tumor-infiltrating lymphocytes (TILs) has shown promising results in cancer treatment, including breast cancer....
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The effect of metformin on senescence of T lymphocytes
BackgroundImmunosenescence occurs as people age, leading to an increased incidence of age-related diseases. The number of senescent T cells also...
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CD4 T-cell aging exacerbates neuroinflammation in a late-onset mouse model of amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is an adult-onset progressive neurodegenerative disorder characterized by the loss of upper and lower motor...
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CD8 T-cell subsets: heterogeneity, functions, and therapeutic potential
CD8 T cells play crucial roles in immune surveillance and defense against infections and cancer. After encountering antigenic stimulation, naïve CD8...
