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Overview of Experimental Vaccines and Antiviral Therapeutics for Henipavirus Infection
Hendra virus (HeV) and Nipah virus (NiV) are highly pathogenic paramyxoviruses, which have emerged in recent decades and cause sporadic outbreaks of...
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Angiogenin as a Possible Mediator of Macrophage-Mediated Regulation of Fibroblast Functions
We studied angiogenin production by human macrophages and evaluated the role of this factor in the macrophage-mediated regulation of fibroblasts. All...
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Augmented antiviral activity of chlorhexidine gluconate on herpes simplex virus type 1, H1N1 influenza A virus, and adenovirus in combination with salicylic acid
BackgroundThe excessive usage of chlorhexidine gluconate (CHG) as a broad-spectrum antimicrobial reagent can have a negative impact on the...
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Map** the influence of hydrocarbons mixture on molecular mechanisms, involved in breast and lung neoplasms: in silico toxicogenomic data-mining
BackgroundExposure to chemical mixtures inherent in air pollution, has been shown to be associated with the risk of breast and lung cancers. However,...
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Comparative systematic review and meta-analysis of reactogenicity, immunogenicity and efficacy of vaccines against SARS-CoV-2
As SARS-CoV-2 vaccines are deployed worldwide, a comparative evaluation is important to underpin decision-making. We here report a systematic...
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Development of a reverse transcription loop-mediated isothermal amplification assay (RT-LAMP) that detects enteroviruses by targeting the highly conserved 5′-UTR region
Enteroviruses are positive sense single-stranded RNA viruses. Most infections from enteroviruses are asymptomatic and can circulate “silently”,...
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Vectorial capacities for malaria in eastern Amazonian Brazil depend on village, vector species, season, and parasite species
BackgroundThe vector species in the Amazon River Basin are regionally and locally diverse, which makes it imperative to understand and compare their...
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Tailoring Multi-Functional 1D or 2D Nanomaterials: An Approach towards Engineering Futuristic Ultrasensitive Platforms for Rapid Detection of Microbial Strains
The coupling of nano-engineered system with appropriate detection mechanism may serve as efficient platforms for screening the presence of these...
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Extracellular Vesicles in Colorectal Cancer Progression, Metastasis, Diagnosis, and Therapy
A few years ago, extracellular vesicles (EVs) came into light for their role in intercommunication between the tumor cells, transferring oncogenic...
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Microwave-assisted synthesis, molecular docking and anti-HIV activities of some drug-like quinolone derivatives
In targeted therapy of breast cancer, human epidermal growth factor receptor 2 HER2 (PDB ID: 3PP0) is being considered as a promising route to design...
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Australian Aedes aegypti mosquitoes are susceptible to infection with a highly divergent and sylvatic strain of dengue virus type 2 but are unlikely to transmit it
BackgroundHumans are the primary hosts of dengue viruses (DENV). However, sylvatic cycles of transmission can occur among non-human primates and...
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First-in-human study of TK-positive oncolytic vaccinia virus delivered by adipose stromal vascular fraction cells
BackgroundACAM2000, a thymidine kinase (TK)-positive strain of vaccinia virus, is the current smallpox vaccine in the US. Preclinical testing...
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Ecotoxicity Databases for QSAR Modeling
Industrial chemicals, pharmaceuticals along with illicit drugs (IDs), as well as day-to-day personal care products (PCPs) are documented as...
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Interaction between Anxiety and Sleep in Experimental Studies and Clinical Practice
High anxiety is a personality features which is largely genetically determined and is due to the functioning of the limbic system and the activity of...
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Cancer cell-derived 12(S)-HETE signals via 12-HETE receptor, RHO, ROCK and MLC2 to induce lymph endothelial barrier breaching
Background:The arachidonic acid metabolite 12(S)-HETE is suspected to enhance metastatic spread by inducing cancer cell- and lymph endothelial cell...
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Experimental infection of Marmota monax with a novel hepatitis A virus
To establish an animal model for the newly identified Marmota Himalayana hepatovirus, MHHAV, so as to develop a better understanding of the infection...
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Applications of Spray-Dried Vaccines
This chapter overviews numerous application studies on spray-dried vaccines, from laboratory-scale research to clinical trials. The main focus is on...
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The non-human reservoirs of Ross River virus: a systematic review of the evidence
AbstractUnderstanding the non-human reservoirs of zoonotic pathogens is critical for effective disease control, but identifying the relative...
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Chikungunya virus transmission between Aedes albopictus and laboratory mice
BackgroundChikungunya virus (CHIKV) is a mosquito-borne alphavirus associated with epidemics of acute and chronic arthritic disease in humans. Aedes...
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