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Neural Stem Cell Intervention in Traumatic Brain Injury
Introduction: Traumatic brain injury (TBI)Traumatic Brain Injury (TBI) is a major cause of death and disability worldwide. The secondary brain damage...
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Stem Cell Therapy and Thiamine Deficiency-Induced Brain Damage
Wernicke’s encephalopathy (WE) is a major central nervous system disorder resulting from thiamine deficiency (TD) in which a number of brain regions...
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Strategies to Upgrade the Stem Cell Application for Brain Transplantation
Introduction: Cerebral stem cellStem cell transplantation has the potential to replace dead cells and restore lost brain functions in...
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Localization of the Stem Cells Exosomes in the Brain and in the Cultured Mouse Brain Cells
Abstract —We studied the possibility of transferring exosomes of neural (NSC) and mesenchymal (MSC) mouse stem cells labeled with the fluorescent dye...
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Development and Developmental Disorders of the Brain Stem
The brain stem is composed of the midbrain (the mesencephalon) and the hindbrain (the rhombencephalon), and is, at least during development,...
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Neuroprotection of Stem Cells Against Ischemic Brain Injury: From Bench to Clinic
Neurological injuries can have numerous debilitating effects on functional status including sensorimotor deficits, cognitive impairment, and...
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Stem Cell-Based Neural Model Systems for Brain Disorders
This detailed volume presents validated and well-adapted procedures involving humanized and/or stem cell-based neural model systems that have proven...
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Stem Cell Therapy for Ischemic Brain Injury: Early Intranasal Delivery after Cardiac Arrest
Global ischemic brain injury is the leading cause of mortality and long-term disability in patients resuscitated from cardiac arrest. Hypothermia and...
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Modeling the Blood-Brain Barrier Using Human-Induced Pluripotent Stem Cells
The blood-brain barrier (BBB) is a key physiological component of the brain, protecting the brain from peripheral processes and pathogens. The BBB is...
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Stem Cell Factor Sox2 and Brain Tumor Development
The SRY (sex determining region Y)-box2 is also known as Sox2 transcription factor (TF) located at Chromosome 3q26.33. It maintains the...
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Emerging Human Pluripotent Stem Cell-Based Human–Animal Brain Chimeras for Advancing Disease Modeling and Cell Therapy for Neurological Disorders
Human pluripotent stem cell (hPSC) models provide unprecedented opportunities to study human neurological disorders by recapitulating human-specific...
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Defined Differentiation of Human Pluripotent Stem Cells to Brain Microvascular Endothelial-Like Cells for Modeling the Blood-Brain Barrier
The blood-brain barrier (BBB) comprises brain microvascular endothelial cells (BMECs) that form a high-resistance cellular interface that separates...
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Mesenchymal Stem Cells Overexpressing FGF21 Preserve Blood-Brain Barrier Integrity in Experimental Ischemic Stroke
Blood-brain barrier (BBB) disruption is a prominent pathophysiological mechanism in stroke. Transplantation of mesenchymal stem cells (MSCs)...
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Brain cancer stem cells: resilience through adaptive plasticity and hierarchical heterogeneity
Malignant brain tumours are complex ecosystems containing neoplastic and stromal components that generate adaptive and evolutionarily driven aberrant...
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Mouse embryonic stem cell-derived blood–brain barrier model: applicability to studying antibody triggered receptor mediated transcytosis
Blood brain barrier (BBB) models in vitro are an important tool to aid in the pre-clinical evaluation and selection of BBB-crossing therapeutics....
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Characterization of an iPSC-based barrier model for blood-brain barrier investigations using the SBAD0201 stem cell line
BackgroundBlood-brain barrier (BBB) models based on primary murine, bovine, and porcine brain capillary endothelial cell cultures have long been...
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Depletion of transit amplifying cells in the adult brain does not affect quiescent neural stem cell pool size
Neural stem cells (NSCs) are maintained in the adult mammalian brain throughout the animal’s lifespan. NSCs in the subependymal zone infrequently...
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Method to Generate Dorsal Forebrain Brain Organoids from Human Pluripotent Stem Cells
Region-specific brain organoids, such as dorsal forebrain brain organoid, have become increasingly useful to model early brain development....
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The ventricular-subventricular, subgranular and subcallosal zones: three niches of neural stem cells in the postnatal brain
In the postnatal brain, three regions show high mitotic activity. These brain areas are neurogenic niches, and each niche harbors a microenvironment...
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A human pluripotent stem cell-derived in vitro model of the blood–brain barrier in cerebral malaria
BackgroundBlood–brain barrier (BBB) disruption is a central feature of cerebral malaria (CM), a severe complication of Plasmodium falciparum ( Pf )...
