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Spatial lipidomics reveals brain region-specific changes of sulfatides in an experimental MPTP Parkinson’s disease primate model
Metabolism of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) to the neurotoxin MPP + in the brain causes permanent Parkinson’s disease-like...
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Disease and brain region specific immune response profiles in neurodegenerative diseases with pure and mixed protein pathologies
The disease-specific accumulation of pathological proteins has long been the major focus of research in neurodegenerative diseases (ND), including...
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Long-read RNA sequencing identifies region- and sex-specific C57BL/6J mouse brain mRNA isoform expression and usage
Alternative splicing (AS) contributes to the biological heterogeneity between species, sexes, tissues, and cell types. Many diseases are either...
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Brain matters: unveiling the distinct contributions of region, age, and sex to glia diversity and CNS function
The myelinated white matter tracts of the central nervous system (CNS) are essential for fast transmission of electrical impulses and are often...
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Region-Dependent Mechanical Properties of Human Brain Tissue Under Large Deformations Using Inverse Finite Element Modeling
This study aims to facilitate intracranial simulation of traumatic events by determining the mechanical properties of different anatomical structures...
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From Determining Brain Insulin Resistance in a Sporadic Alzheimer’s Disease Model to Exploring the Region-Dependent Effect of Intranasal Insulin
Impaired response to insulin has been linked to many neurodegenerative disorders like Alzheimer’s disease (AD). Animal model of sporadic AD has been...
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May we routinely spare hippocampal region in primary central nervous system lymphoma during whole brain radiotherapy?
PurposeOne of the main limiting factors of whole-brain radiation therapy (WBRT) for primary central nervous system lymphoma (PCNSL) is the impairment...
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A tool for map** microglial morphology, morphOMICs, reveals brain-region and sex-dependent phenotypes
Environmental cues influence the highly dynamic morphology of microglia. Strategies to characterize these changes usually involve user-selected...
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Time and Brain Region-Dependent Excitatory Neurochemical Alterations in Bilateral Common Carotid Artery Occlusion Global Ischemia Model
Strict metabolic regulation in discrete brain regions leads to neurochemical changes in cerebral ischemia. Accumulation of extracellular glutamate is...
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Architecture and connectivity of the human angular gyrus and of its homolog region in the macaque brain
The angular gyrus roughly corresponds to Brodmann’s area 39, which is a multimodal association brain region located in the posterior apex of the...
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Exploring Piezo1, Piezo2, and TMEM150C in human brain tissues and their correlation with brain biomechanical characteristics
Unraveling the intricate relationship between mechanical factors and brain activity is a pivotal endeavor, yet the underlying mechanistic model of...
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Daytime Light Deficiency Leads to Sex- and Brain Region-Specific Neuroinflammatory Responses in a Diurnal Rodent
Seasonal changes in peripheral inflammation are well documented in both humans and animal models, but seasonal changes in neuroinflammation,...
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Localization of the Stem Cells Exosomes in the Brain and in the Cultured Mouse Brain Cells
Abstract —We studied the possibility of transferring exosomes of neural (NSC) and mesenchymal (MSC) mouse stem cells labeled with the fluorescent dye...
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Region-Dependent Viscoelastic Properties of Human Brain Tissue Under Large Deformations
This study characterizes the mechanical properties of human brain tissue resected during the course of surgery under multistep indentation loading up...
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In Vivo Brain Microdialysis
Many biological molecules in the brain interstitial fluid are involved in neuronal functions. Therefore, measuring the levels of these molecules in...
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Investigating nutrient biomarkers of healthy brain aging: a multimodal brain imaging study
The emerging field of Nutritional Cognitive Neuroscience aims to uncover specific foods and nutrients that promote healthy brain aging. Central to...
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Link Brain-Wide Projectome to Neuronal Dynamics in the Mouse Brain
Knowledge about the neuronal dynamics and the projectome are both essential for understanding how the neuronal network functions in concert. However,...
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Negative modulation of AMPA receptors bound to transmembrane AMPA receptor regulatory protein γ-8 blunts the positive reinforcing properties of alcohol and sucrose in a brain region-dependent manner in male mice
RationaleThe development and progression of alcohol use disorder (AUD) are widely viewed as maladaptive neuroplasticity. The transmembrane...
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Linking Models with Brain Measures
Linking models and brain measures offers a number of advantages over standard analyses. Models that have been evaluated on previous datasets can...
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How deep is the brain? The shallow brain hypothesis
Deep learning and predictive coding architectures commonly assume that inference in neural networks is hierarchical. However, largely neglected in...
