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Bovine Tuberculosis at the Interface of Cattle, Wildlife, and Humans
General awareness of zoonotic diseasesDiseaseZoonotic has been heightened by the SARS-CoV-2 pandemicPandemic, but in truth, emerging zoonotic...
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Tuberculosis
Tuberculosis is one of the major global health concerns associated with a high morbidity and mortality rate. Pulmonary tuberculosis may remain latent...
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Animal Models of Tuberculosis
Tuberculosis (TB) is an important zoonotic disease caused by infection with Mycobacterium tuberculosis (Mtb) complex and has a significant impact on...
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Tuberculosis: Integrated Studies for a Complex Disease 2050
The authors of Tuberculosis: Integrated Studies for a Complex Disease were asked how they would see the future of their field 30 years later. This...
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Evolution and Molecular Characteristics of Mycobacterium tuberculosis and Mycobacterium bovis
In the last decade, a major genomicsGenomics revolution took place in life and health sciences that shed light on the biologyBiology and...
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Tuberculosis: Experimental Models, Innovations, and Challenges
Tuberculosis (TB) is among the top ten killer diseases and remains the number one cause of death due to infection. A major bottleneck in TB research...
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Macrophage-Targeted Chemotherapy for Tuberculosis
The emergence and frequent occurrence of multidrug-resistant strains of Mycobacterium tuberculosis (the causative pathogen for the deadly infectious...
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Important Targets and Inhibitors of Mycobacterium tuberculosis
Tuberculosis (TB) is a global health issue. Millions of TB-infected patients remain undiagnosed, untreated, or improperly treated, leading to...
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Genus Mycobacterium and Mycobacterium tuberculosis
The genus Mycobacterium included in the family Mycobacteriaceae consists of non-motile, non-spore-forming and aerobic bacilli. They are slightly...
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Exploring the potential of Lactocaseibacillus rhamnosus PMC203 in inducing autophagy to reduce the burden of Mycobacterium tuberculosis
Mycobacterium tuberculosis , a lethal pathogen in human history, causes millions of deaths annually, which demands the development of new concepts of...
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Animal Tuberculosis: Gross Lesions and Anatomopathological Diagnosis
Animal tuberculosisTuberculosisanimal (TB) is a zoonotic diseaseDiseaseZoonotic with worldwide distributionDistribution that can cause serious...
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The VALIDATE Network: Accelerating Vaccine Development for Tuberculosis, Leishmaniasis, Melioidosis and Leprosy
Established in June 2017, VALIDATE is an international network of researchers working to accelerate vaccine development for four neglected...
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Global-scale GWAS associates a subset of SNPs with animal-adapted variants in M. tuberculosis complex
BackgroundWhile Mycobacterium tuberculosis complex (MTBC) variants are clonal, variant tuberculosis is a human-adapted pathogen, and variant bovis ...
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Expression of mammalian cell entry genes in clinical isolates of M. tuberculosis and the cell entry potential and immunological reactivity of the Rv0590A protein
Mammalian cell entry ( mce ) operons play a vital role in cell invasion and survival of M. tuberculosis . Of the mce genes, the function of Rv0590A is...
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Chronic hyperglycemia impairs anti-microbial function of macrophages in response to Mycobacterium tuberculosis infection
Diabetes mellitus (DM) is a major risk factor for tuberculosis (TB), though the underlying mechanisms linking DM and TB remain ambiguous. Macrophages...
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Tyrosine inhibits the Mycobacterium tuberculosis protein tyrosine phosphatase MptpA
The catalytic action of the low-molecular weight protein tyrosine phosphatase (MptpA), expressed by Mycobacterium tuberculosis , is known to be...
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Integrated bioinformatics analysis of dendritic cells hub genes reveal potential early tuberculosis diagnostic markers
BackgroundDendritic cells (DCs) are most potent antigen-processing cells and play key roles in host defense against Mycobacterium tuberculosis (MTB)...
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Effects of Encapsulation of Caesalpinia sappan L. with Cyclodextrins for Bovine Mastitis
The main components of Caesalpinia sappan L. (CS) are brazilin and brazilein, which show high potential in pharmacologic applications. However, these...
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Bovine Collectins: Role in Health and Disease
Mammalian collectins play key roles in innate immunity, health and disease. These have been well studied in humans and other mammalian species, but...
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Lysozyme: an endogenous antimicrobial protein with potent activity against extracellular, but not intracellular Mycobacterium tuberculosis
Endogenous antimicrobial peptides (AMPs) play a key role in the host defense against pathogens. AMPs attack pathogens preferentially at the site of...
