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Optimized Pre-analytical Handling Protocol for Blood-Based Biomarkers of Alzheimer’s Disease
The therapeutic management of patients with Alzheimer’s disease (AD) has been hindered by poor diagnostic accuracy. As such, there is an unmet...
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Blood and CSF Biomarkers in Autosomal Dominant Cerebellar Ataxias
A biomarker can be defined as a measurable indicator of the presence or severity of a disease state, often present before clinical signs are evident....
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In Silico Models to Validate Novel Blood-Based Biomarkers
Biological validation of preliminary findings is a key prerequisite in biomarker discovery. In recent years, the development of advanced large-scale...
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Liquid-based biomarkers in breast cancer: looking beyond the blood
In recent decades, using circulating tumor cell (CTC), circulating tumor DNA (ctDNA), circulating tumor RNA (ctRNA), exosomes and etc. as liquid...
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Blood-Based Biomarkers for Early Alzheimer’s Disease Diagnosis in Real-World Settings
As our knowledge about the biology of Alzheimer’s disease (AD) expands and we recognize the significance of early intervention for effective...
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Transcriptomic imputation of genetic risk variants uncovers novel whole-blood biomarkers of Parkinson’s disease
Blood-based gene expression signatures could potentially be used as biomarkers for PD. However, it is unclear whether genetically-regulated...
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Blood-based biomarkers in Alzheimer’s disease: a mini-review
Alzheimer’s disease (AD) is the most common cause of dementia and has far reaching consequences for patients and their caregivers. Early detection...
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Evaluation of blood and urine based biomarkers for detection of clinically-significant prostate cancer
BackgroundRecognizing the limitations of prostate-specific antigen (PSA) screening and the morbidity of prostate biopsies, several blood- and...
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Alzheimer blood biomarkers: practical guidelines for study design, sample collection, processing, biobanking, measurement and result reporting
Alzheimer’s disease (AD), the most common form of dementia, remains challenging to understand and treat despite decades of research and clinical...
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Pediatric sepsis inflammatory blood biomarkers that correlate with clinical variables and severity of illness scores
BackgroundSepsis is a dysregulated systemic inflammatory response triggered by infection, resulting in organ dysfunction. A major challenge in...
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Blood-based biomarkers in patients with non-small cell lung cancer treated with immune checkpoint blockade
The paradigm of non-small cell lung cancer (NSCLC) treatment has been profoundly influenced by the development of immune checkpoint inhibitors (ICI),...
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Neuroinflammatory Biomarkers in the Brain, Cerebrospinal Fluid, and Blood After Ischemic Stroke
The most frequent type of stroke, known as ischemic stroke (IS), is a significant global public health issue. The pathological process of IS and...
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Blood Count Profiles as Biomarkers in Burns: Red Cells, Platelets, and Beyond
The search for biomarkers that help physicians in medical practice has been a topic of great interest in the last decades. Burned patients represent...
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Apo10 and TKTL1 in blood macrophages as biomarkers for differentiating lung cancer from benign lung lesions: a comparative study with conventional biomarkers
The detection of biomarkers in blood macrophages is a new non-invasive cancer screening method, but its performance in early stage lung cancer...
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Alzheimer’s and neurodegenerative disease biomarkers in blood predict brain atrophy and cognitive decline
BackgroundAlthough blood-based biomarkers have been identified as cost-effective and scalable alternatives to PET and CSF markers of...
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Transcriptomic analyses of patient peripheral blood with hemoglobin depletion reveal glioblastoma biomarkers
Peripheral blood is gaining prominence as a noninvasive alternative to tissue biopsy to develop biomarkers for glioblastoma (GBM); however, widely...
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Extracellular Vesicle Biomarkers for Neurological Diseases
Different cells in the central nervous system can produce and release extracellular vesicles (EVs), which carry proteins, lipids, DNA, mRNAs,...
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Subjective cognitive complaints and blood biomarkers of neurodegenerative diseases: a longitudinal cohort study
BackgroundSubjective cognitive complaints (SCC) have been mostly studied in the context of Alzheimer’s disease in memory clinic settings. The...
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Deamidation-related blood biomarkers show promise for early diagnostics of neurodegeneration
BackgroundThe strongest risk factor of neurodegenerative diseases (NDDs) is aging. Spontaneous asparaginyl deamidation leading to formation of...
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Blood biomarkers and neurodegeneration in individuals exposed to repetitive head impacts
BackgroundIt is unknown if fluid biomarkers reflective of brain pathologies are useful in detecting and following a neurodegenerative process in...
