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Basement membrane-related MMP14 predicts poor prognosis and response to immunotherapy in bladder cancer
BackgroundBasement membrane (BM) is an important component of the extracellular matrix, which plays an important role in the growth and metastasis of...
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The anti-inflammatory effect of myrrh ethanolic extract in comparison with prednisolone on an autoimmune disease rat model induced by silicate
Autoimmune disease is a complex chronic disease that triggers immune activation against autoantigens resulting in tissue damage. Epidemiological data...
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Evaluation of chicory leaf extract on chronic kidney disease model in streptozotocin-induced diabetic nephropathy
This study aimed to evaluate Chicory leaf extract for its potential activity on CKD model in STZ induced diabetic nephropathy in Wistar albino rats....
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Rat corneal endothelial cell migration during wound repair on the basement membrane depends more on the PI-3K pathway than the cdc-42 pathway or actin stress fibers
Following a central transcorneal circular freeze injury, organ-cultured rat corneal endothelial cells surrounding the wound reorganize peripheral...
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Screening impacts of Tilmicosin-induced hepatic and renal toxicity in rats: protection by Rhodiola rosea extract through the involvement of oxidative stress, antioxidants, and inflammatory cytokines biomarkers
Tilmicosin (TIL) is a semisynthetic macrolide antibiotic with a broad spectrum of activity derived from tylosin. TIL is effective in the treatment of...
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Cinnamon bark extract suppresses metastatic dissemination of cancer cells through inhibition of glycolytic metabolism
Metastasis is responsible for approximately 90% of cancer-associated mortality and proceeds through multiple steps. Several herbal medicines are...
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Bajitianwan formula extract ameliorates bone loss induced by iron overload via activating RAGE/PI3K/AKT pathway based on network pharmacology and transcriptomic analysis
Osteoporosis (OP) is closely related to iron overload. Bajitianwan (BJTW) is a traditional Chinese medicine formulation used for treating senile...
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Biofabrication, biochemical profiling, and in vitro applications of salivary gland decellularized matrices via magnetic bioassembly platforms
Trending three-dimensional tissue engineering platforms developed via biofabrication and bioprinting of exocrine glands are on the rise due to a...
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Chorioallantoic Membrane (CAM) and In Ovo Models as Potential Platforms for Testing Cancer Agents
The construction of clinically related models for cancer metastasis and anticancer testing plays a significant role in evidence-based translational...
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Extracellular Matrix Glycation and Crosslinking in Mammary Tumor Progression
Breast cancer progression is accompanied by profound extracellular matrix (ECM) remodeling. A greater abundance of aligned fibrillar collagen is...
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Sesquiterpene from Polygonum barbatum disrupts mitochondrial membrane potential to induce apoptosis and inhibits metastasis by downregulating matrix metalloproteinase and osteopontin in NCI-H460 cells
Globally, lung cancer accounts for 18% of cancer-associated mortalities. Among the subtypes, non-small cell lung cancer (NSCLC) is the most...
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Human umbilical cord mesenchymal stem cells attenuate diabetic nephropathy through the IGF1R-CHK2-p53 signalling axis in male rats with type 2 diabetes mellitus
Diabetes mellitus (DM) is a disease syndrome characterized by chronic hyperglycaemia. A long-term high-glucose environment leads to reactive oxygen...
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Nanocarriers as an Emerging Tool for Drug Delivery to Combat Neurodegenerative Diseases
The central nervous system (CNS)-related diseases pose a significant challenge due to the inherent blood–brain barrier (BBB) that hampers the drug...
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Label-Free Monitoring of Endometrial Cancer Progression Using Multiphoton Microscopy
Endometrial cancer is the most common gynecological cancer in the developed world. However, the accuracy of current diagnostic methods is still...
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Chorioallantoic Membrane (CAM) and In Ovo Models as Potential Platforms for Testing Cancer Agents
The construction of clinically related models for cancer metastasis and anticancer testing plays a significant role in evidence-based translational...
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Toxicity profile of Phaleria macrocarpa (Scheff.) Boerl. fruits extract in adult male Sprague-Dawley rats
The fruits of Phaleria macrocarpa (PM) have long been used as a traditional Malay medicinal herb for hundreds of years. To determine the toxicity of...
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The impairment of intramural periarterial drainage in brain after subarachnoid hemorrhage
Interstitial fluid (ISF) from brain drains along the basement membranes of capillaries and arteries as Intramural Periarterial Drainage (IPAD);...
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Delineating three-dimensional behavior of uveal melanoma cells under anchorage independent or dependent conditions
BackgroundAlthough rare, uveal melanoma (UM) is a life-threatening malignancy. Understanding its biology is necessary to improve disease outcome....
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Tetrorchidium didymostemon leaf extract reduces Plasmodium berghei induced oxidative stress and hepatic injury in Swiss albino mice
Oxidative stress, already implicated in malaria infection has been identified as one of the major contributors to the pathophysiology of malaria....
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Investigation of MT1-MMP Activity in Cancer Cells
Membrane-type 1 matrix metalloproteinase (MT1-MMP, also called MMP14) is one of the significant cell invasion drivers. MT1-MMP has been shown to play...