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Meta-analysis of Transcriptomic Data from Lung Autopsy and Cellular Models of SARS-CoV-2 Infection
Severe COVID-19 is a systemic disorder involving excessive inflammatory response, metabolic dysfunction, multi-organ damage, and several clinical...
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Early tau detection in flortaucipir images: validation in autopsy-confirmed data and implications for disease progression
BackgroundThere is an increasing interest in utilizing tau PET to identify patients early in Alzheimer’s disease (AD). In this work, a temporal lobe...
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Genomic autopsy to identify underlying causes of pregnancy loss and perinatal death
Pregnancy loss and perinatal death are devastating events for families. We assessed ‘genomic autopsy’ as an adjunct to standard autopsy for...
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Prevalence of subclinical lung cancer detected at autopsy: a systematic review
BackgroundLung cancer screening in high-risk populations with low-dose computed tomography is supported by international associations and...
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Exploratory Mass Spectrometry of Cerebrospinal Fluid from Persons with Autopsy-Confirmed LATE-NC
Common neuropathologies associated with dementia include Alzheimer’s disease neuropathologic change (ADNC) and limbic-predominant age-related TDP-43...
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ADNP dysregulates methylation and mitochondrial gene expression in the cerebellum of a Helsmoortel–Van der Aa syndrome autopsy case
BackgroundHelsmoortel–Van der Aa syndrome is a neurodevelopmental disorder in which patients present with autism, intellectual disability, and...
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Neurodegenerative pathologies associated with behavioral and psychological symptoms of dementia in a community-based autopsy cohort
In addition to the memory disorders and global cognitive impairment that accompany neurodegenerative diseases, behavioral and psychological symptoms...
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Cognitive, functional, and neuropsychiatric correlates of regional tau pathology in autopsy-confirmed chronic traumatic encephalopathy
BackgroundChronic traumatic encephalopathy (CTE) is a neurodegenerative disease characterized by hyperphosphorylated tau (p-tau) accumulation. The...
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Same performance of exome sequencing before and after fetal autopsy for congenital abnormalities: toward a paradigm shift in prenatal diagnosis?
Prenatal exome sequencing could be complex because of limited phenotypical data compared to postnatal/portmortem phenotype in fetuses affected by...
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Association between APOE-ε4 allele and cognitive function is mediated by Alzheimer’s disease pathology: a population-based autopsy study in an admixed sample
BackgroundApolipoprotein E ε4 allele (APOE-ε4) is the main genetic risk factor for late-onset Alzheimer’s disease (AD) and may impact cognitive...
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Lethal variants in humans: lessons learned from a large molecular autopsy cohort
BackgroundMolecular autopsy refers to DNA-based identification of the cause of death. Despite recent attempts to broaden its scope, the term remains...
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Structural MRI profiles and tau correlates of atrophy in autopsy-confirmed CTE
BackgroundChronic traumatic encephalopathy (CTE), a neurodegenerative tauopathy, cannot currently be diagnosed during life. Atrophy patterns on...
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Improving methods to measure comparable mortality by cause (IMMCMC): gold standard verbal autopsy dataset
ObjectivesGold standard cause of death data is critically important to improve verbal autopsy (VA) methods in diagnosing cause of death where civil...
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Argyrophilic grain disease is common in older adults and may be a risk factor for suicide: a study of Japanese forensic autopsy cases
BackgroundNeuropathological diagnosis of argyrophilic grain disease (AGD) is currently based primarily on the combination of argyrophilic grain (AG)...
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Focal amyloid and asymmetric tau in an imaging-to-autopsy case of clinical primary progressive aphasia with Alzheimer disease neuropathology
Quantification of in vivo amyloid and tau PET imaging relationships with postmortem measurements are critical for validating the sensitivity and...
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APOE ε4 associates with increased risk of severe COVID-19, cerebral microhaemorrhages and post-COVID mental fatigue: a Finnish biobank, autopsy and clinical study
Apolipoprotein E ε4 allele ( APOE4 ) has been shown to associate with increased susceptibility to SARS-CoV-2 infection and COVID-19 mortality in some...
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Novel temporal and spatial patterns of metastatic colonization from breast cancer rapid-autopsy tumor biopsies
BackgroundMetastatic breast cancer is a deadly disease with a low 5-year survival rate. Tracking metastatic spread in living patients is difficult...
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Predictors of cognitive impairment in primary age-related tauopathy: an autopsy study
Primary age-related tauopathy (PART) is a form of Alzheimer-type neurofibrillary degeneration occurring in the absence of amyloid-beta (Aβ) plaques....
