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The Impact of Standard Ablation Strategies for Atrial Fibrillation on Cardiovascular Performance in a Four-Chamber Heart Model
PurposeAtrial fibrillation is one of the most frequent cardiac arrhythmias in the industrialized world and ablation therapy is the method of choice...
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Validating MRI-Derived Myocardial Stiffness Estimates Using In Vitro Synthetic Heart Models
Impaired cardiac filling in response to increased passive myocardial stiffness contributes to the pathophysiology of heart failure. By leveraging...
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Granulocytes-Rich Thrombi in Cerebral Large Vessel Occlusion Are Associated with Increased Stiffness and Poorer Revascularization Outcomes
We aim to identify a profile of intracranial thrombus resistant to recanalization by mechanical thrombectomy (MT) in acute stroke treatment. The...
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Arterial Stiffness May Predict Subsequent Cancer Therapy-Related Cardiac Dysfunction in Breast Cancer Patients
Cancer therapy-related cardiac dysfunction (CTRCD) is still a serious problem. Existing risk scores are insufficient for risk classification,...
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Causal effects between atrial fibrillation and heart failure: evidence from a bidirectional Mendelian randomization study
BackgroundObservational studies have suggested a close association between atrial fibrillation (AF) and heart failure (HF), yet the causal effect...
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Cardiovascular medications used for comorbid diseases in patients with atrial fibrillation. The JoFib study
PurposeMany atrial fibrillation (AF) patients use cardiovascular medications for indications other than AF. These medications can affect morbidity...
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Myocardial Biomechanics and the Consequent Differentially Expressed Genes of the Left Atrial Ligation Chick Embryonic Model of Hypoplastic Left Heart Syndrome
Left atrial ligation (LAL) of the chick embryonic heart is a model of the hypoplastic left heart syndrome (HLHS) where a purely mechanical...
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Mutual effect of homocysteine and uric acid on arterial stiffness and cardiovascular risk in the context of predictive, preventive, and personalized medicine
BackgroundArterial stiffness is a major risk factor and effective predictor of cardiovascular diseases and a common pathway of pathological vascular...
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Left atrial mechanics and aortic stiffness following high intensity interval training: a randomised controlled study
PurposeHigh intensity interval training (HIIT) has been shown to improve important health parameters, including aerobic capacity, blood pressure,...
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Genomic approaches to identify and investigate genes associated with atrial fibrillation and heart failure susceptibility
Atrial fibrillation (AF) and heart failure (HF) contribute to about 45% of all cardiovascular disease (CVD) deaths in the USA and around the globe....
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Effects of Left Ventricular Hypertrophy and Myocardial Stiffness on Myocardial Strain Under Preserved Ejection Fraction
Despite numerous experimental observations regarding heart failure with preserved ejection fraction (HFpEF), which is characterized mainly by left...
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Effects of Ageing on Aortic Circulation During Atrial Fibrillation; a Numerical Study on Different Aortic Morphologies
Atrial fibrillation (AF) can alter intra-cardiac flow and cardiac output that subsequently affects aortic flow circulation. These changes may become...
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The impact of progredient vessel and tissue stiffening for the development of metabolic syndrome
Established risk factors for the metabolic syndrome as diabetes and arterial hypertension are believed to be the cause of arteriosclerosis and...
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Botulinum Toxin Therapy-Future Perspectives
New potential applications for botulinum neurotoxin (BoNT) therapy are constantly emerging through the expanding literature in the field of clinical...
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15 weeks of soccer training increases left ventricular mass and improves indices of left ventricular diastolic function in previously sedentary, mildly hypertensive, middle-aged women
PurposeTo investigate the impact of soccer training on cardiac adaptations in mildly hypertensive middle-aged women.
MethodsHypertensive...
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Association of central blood pressure with an exaggerated blood pressure response to exercise among elite athletes
PurposeThe systolic blood pressure/workload (SBP/MET) slope was recently reported to be a reliable parameter to identify an exaggerated blood...
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Association between insulin resistance and cardiac remodeling in HER2-positive breast cancer patients: a real-world study
BackgroundInsulin resistance is an overlap** risk factor for both heart and breast cancer, while its interaction with cardiotoxicity in breast...
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Renin Angiotensin System and Obesity-Related Organ Damage
ObesityObesity is a growing global disease that results in serious health risks. ObesityObesity is a known cause of arterial...
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Cyanidin prevents cardiomyocyte apoptosis in mice after myocardial infarction
Myocardial infarction is a worldwide disease with high morbidity and mortality and a major cause of chronic heart failure, seriously affecting...
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Porcine Model of Hypertrophy-Independent Left Ventricular Stiffening via Repetitive Pressure Overload
Diastolic dysfunction arising from alterations in myocardial structure and/or function is a central component of several cardiovascular disorders,...