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Holocord pilocytic astrocytoma in a young woman with intracranial extension: case report and review of the MRI characteristics
IntroductionPilocytic astrocytoma is a low-grade glioma more frequently seen in patients <20. It is pretty uncommon in the spinal cord. Rarely,...
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Nitroproteomics is instrumental for stratification and targeted treatments of astrocytoma patients: expert recommendations for advanced 3PM approach with improved individual outcomes
Protein tyrosine nitration is a selectively and reversible important post-translational modification, which is closely related to oxidative stress....
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Genetic alterations that deregulate RB and PDGFRA signaling pathways drive tumor progression in IDH2-mutant astrocytoma
In IDH -mutant astrocytoma, IDH2 mutation is quite rare and biological mechanisms underlying tumor progression in IDH2 -mutant astrocytoma remain...
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Genomic characterization of IDH-mutant astrocytoma progression to grade 4 in the treatment setting
As the progression of low-grade diffuse astrocytomas into grade 4 tumors significantly impacts patient prognosis, a better understanding of this...
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Molecular landscape of IDH-mutant astrocytoma and oligodendroglioma grade 2 indicate tumor purity as an underlying genomic factor
BackgroundIDH-mutant astrocytoma and oligodendroglioma have an indolent natural history and are recognized as distinct entities of neoplasms. There...
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Desmoplastic infantile astrocytoma with atypical phenotype, PTEN homozygous deletion and BRAF V600E mutation
Desmoplastic infantile astrocytoma (DIA) is rare, cystic and solid tumor of infants usually found in superficial cerebral hemispheres. Although DIA...
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Clinical outcomes and a therapeutic indication of intramedullary spinal cord astrocytoma
Study designRetrospective cohort study.
ObjectivesAlthough intramedullary astrocytoma is associated with a high mortality rate, the optimal...
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Local detection of microvessels in IDH-wildtype glioblastoma using relative cerebral blood volume: an imaging marker useful for astrocytoma grade 4 classification
BackgroundThe microvessels area (MVA), derived from microvascular proliferation, is a biomarker useful for high-grade glioma classification....
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Atypical presentation of spinal intramedullary astrocytoma in a patient presenting with isolated signs of intracranial hypertension
IntroductionIntramedullary spinal tumors are rare entities that typically present with signs of spinal cord dysfunction including myelopathy,...
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Association of ST6GAL1 and CYP19A1 polymorphisms in the 3′-UTR with astrocytoma risk and prognosis in a Chinese Han population
BackgroundAstrocytoma is a common type of central nervous system tumor. In this study, we investigated the correlation between ST6GAL1 and CYP19A1 ...
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Patient-reported outcomes in Primary Spinal Intradural Tumours: a systematic review
Study designSystematic review.
ObjectivesPrimary Spinal Intradural Tumours (PSITs) are rare pathologies that can significantly impact quality of...
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Demographic and prognostic factors of optic nerve astrocytoma: a retrospective study of surveillance, epidemiology, and end results (SEER)
BackgroundOptic nerve astrocytomas (ONAs) are neurological neoplasms in the central nervous system (CNS), and they have the highest incidence rate...
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CD13 expression affects glioma patient survival and influences key functions of human glioblastoma cell lines in vitro
CD13 (APN) is an Alanyl-Aminopeptidase with diverse functions. The role of CD13 for gliomas is still unknown. In this study, data of glioma patients...
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Predicting survival in anaplastic astrocytoma patients in a single-center cohort of 108 patients
BackgroundCurrent guidelines for the treatment of anaplastic astrocytoma (AA) recommend maximal safe resection followed by radiotherapy and...
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Strategies for diagnosis and management of CMMRD in low-resource countries: report of a Tunisian family
Constitutional Mismatch Repair Deficiency (CMMRD) is a rare childhood cancer predisposition syndrome, caused by biallelic pathogenic germline...
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Nuclear Respiratory Factor 1 (NRF1) Transcriptional Activity-Driven Gene Signature Association with Severity of Astrocytoma and Poor Prognosis of Glioblastoma
Despite tremendous progress in understanding the pathobiology of astrocytoma, major gaps remain in our knowledge of the molecular basis underlying...
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Detection and genomic analysis of BRAF fusions in Juvenile Pilocytic Astrocytoma through the combination and integration of multi-omic data
BackgroundJuvenile Pilocytic Astrocytomas (JPAs) are one of the most common pediatric brain tumors, and they are driven by aberrant activation of the...
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Glioma Cells Expressing High Levels of ALDH5A1 Exhibit Enhanced Migration Transcriptional Signature in Patient Tumors
Accumulating data shows that altered metabolic activity contributes to glioma development. Recently, modulation of SSADH (succinic semialdehyde...
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A refractory case of CDK4-amplified spinal astrocytoma achieving complete response upon treatment with a Palbociclib-based regimen:a case report
BackgroundSpinal cord astrocytoma is a rare neoplasm, and patients usually recur within months after surgery. There is currently a lack of consensus...
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Role of Myc in Brain Tumor Development
First-time N-myc amplification was reported in malignant astrocytoma (Garson et al. 1985). Myc is a family of proto-oncogenes. There are three...