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TGF-β gene polimorphisms as risk factors for asthma control among clinic patients
BackgroundTGF-β and its receptors play a crucial role in asthma pathogenesis, bronchial hyperreactivity, and bronchial remodeling. Expression of...
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Integrated study of systemic and local airway transcriptomes in asthma reveals causal mediation of systemic effects by airway key drivers
BackgroundSystemic and local profiles have each been associated with asthma, but parsing causal relationships between system-wide and airway-specific...
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Three Main SCFAs Mitigate Lung Inflammation and Tissue Remodeling Nlrp3-Dependent in Murine HDM-Induced Neutrophilic Asthma
Neutrophilic asthma is generally defined by poorly controlled symptoms and high levels of neutrophils in the lungs. Short-chain fatty acids (SCFAs)...
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Identification of asthma-related genes using asthmatic blood eQTLs of Korean patients
BackgroundMore than 200 asthma-associated genetic variants have been identified in genome-wide association studies (GWASs). Expression quantitative...
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IL-23 contributes to Particulate Matter induced allergic asthma in the early life of mice and promotes asthma susceptibility
AbstractAir pollutant exposure leads to and exacerbates respiratory diseases. Particulate Matter (PM) is a major deleterious factor in the...
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Association between circulating fatty acid metabolites and asthma risk: a two-sample bidirectional Mendelian randomization study
BackgroundFatty acids are involved in a wide range of immunological responses in humans. Supplementation of polyunsaturated fatty acids has been...
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Exploring the therapeutic potential of monoclonal antibodies targeting TSLP and IgE in asthma management
BackgroundIn recent years, there has been a growing interest in the utilization of biologic therapies for the management of asthma. Both TSLP and IgE...
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Mitochondria protective and anti-apoptotic effects of peripheral benzodiazepine receptor and its ligands on the treatment of asthma in vitro and vivo
BackgroundAsthma is a prevalent respiratory inflammatory disease. Abnormal apoptosis of bronchial epithelial cells is one of the major factors in the...
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The implication of infection with respiratory syncytial virus in pediatric recurrent wheezing and asthma: knowledge expanded post-COVID-19 era
BackgroundRespiratory syncytial virus (RSV) infection has been identified to serve as the primary cause of acute lower respiratory infectious...
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Interplay of IL-33 and IL-35 Modulates Th2/Th17 Responses in Cigarette Smoke Exposure HDM-Induced Asthma
Cigarette smoke (CS) facilitates adverse effects on the airway inflammation and treatment of asthma. Here, we investigated the mechanisms by which CS...
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Safety of Biological Therapies for Severe Asthma: An Analysis of Suspected Adverse Reactions Reported in the WHO Pharmacovigilance Database
BackgroundThe management of uncontrolled severe asthma has greatly improved since the advent of novel biologic therapies. Up to August 2022, five...
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Smokeless tobacco enhances allergic inflammation, aggravation of asthma and oxidative stress in asthmatic patients from Algeria
PurposeDespite their effects on human health, the link between smokeless tobacco (ST) consumption and asthma severity in asthmatic patients is still...
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The upregulation of peripheral CD3-CD56+CD16+ natural killer cells correlates with Th1/Th2 imbalance in asthma patients during acute upper respiratory viral infections
PurposeThe aim of this study is to clarify the changes of peripheral CD3 − CD56 + CD16 + NK cells and their correlation with Th1/Th2 immunity profiles in...
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An integrated metabo-lipidomics profile of induced sputum for the identification of novel biomarkers in the differential diagnosis of asthma and COPD
BackgroundDue to their complexity and to the presence of common clinical features, differentiation between asthma and chronic obstructive pulmonary...
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New phosphodiesterase-4 inhibitors present airways relaxant activity in a guinea pig acute asthma model
Asthma is a disease characterized by chronic inflammation and hyper responsiveness of airways. We aimed to assess the relaxant potential of...
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Compliance of Bronchial Asthma Patients’ with the Mediterranean Diet
Introduction: Asthma is considered the most common chronic disease that affects survival and quality of life. An astringent regulatory factor of...
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Serum decoy receptor 3 (DcR3): a promising biomarker for atopic asthma in children
Bronchial asthma is a common chronic inflammatory disease with high prevalence and morbidity, particularly in school-aged children. Decoy receptor 3...
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Silencing lncRNA CDKN2B-AS1 Alleviates Childhood Asthma Progression Through Inhibiting ZFP36 Promoter Methylation and Promoting NR4A1 Expression
LncRNA cyclin-dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B-AS1) was found to be upregulated in plasma of patients with bronchial asthma....
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Alternatively activated macrophages promote airway inflammation through JAK3–STAT5–Fra2 in asthma
BackgroundFos-related antigen-2 (Fra-2) is a transcription factor belonging to the activator protein 1 (AP-1) family, which is associated with many...
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Collagen Triple Helix Repeat Containing 1 Deficiency Protects Against Airway Remodeling and Inflammation in Asthma Models In Vivo and In Vitro
Asthma is a chronic inflammatory disease characterized by airway remodeling and lung inflammation. Collagen triple helix repeat containing 1...
