Search
Search Results
-
Changes in miRNA expression in patients with peripheral arterial vascular disease during moderate- and vigorous-intensity physical activity
BackgroundWalking is the preferred therapy for peripheral arterial disease in early stage. An effect of walking exercise is the increase of blood...
-
Mast Cells in Arteriogenesis
Arteriogenesis is defined as the growth of functional collateral arteries from pre-existing arterio-arteriolar anastomoses. It is induced as a...
-
Renin Angiotensin System in the Maturation and Failure of Arterio-Venous Fistula
An arteriovenous fistulaArteriovenous fistula (AVF) is the most used vascular access for hemodialysis but is associated with failure occurring within...
-
The promotion action of AURKA on post-ischemic angiogenesis in diabetes-related limb ischemia
BackgroundDiabetes-related limb ischemia is a challenge for lower extremity amputation. Aurora Kinase A (AURKA) is an essential serine/threonine...
-
Cell Therapy of Severe Ischemia in People with Diabetic Foot Ulcers—Do We Have Enough Evidence?
This current opinion article critically evaluates the efficacy of autologous cell therapy (ACT) for chronic limb-threatening ischemia (CLTI),...
-
Structural, angiogenic, and immune responses influencing myocardial regeneration: a glimpse into the crucible
Complete cardiac regeneration remains an elusive therapeutic goal. Although much attention has been focused on cardiomyocyte proliferation,...
-
Role of High Mobility Group Box 1 in Cardiovascular Diseases
High Mobility Group Box 1 (HMGB1) is a ubiquitous, highly conserved nuclear and cytosolic protein that has diverse biological roles depending on its...
-
PHD1-3 oxygen sensors in vivo—lessons learned from gene deletions
Oxygen sensors enable cells to adapt to limited oxygen availability (hypoxia), affecting various cellular and tissue responses. Prolyl-4-hydroxylase...
-
Modulators and Poststroke Behavioral Changes
Neuro-pathophysiological conditions like cerebrovascular accident (CVA) or stroke are linked to insufficient blood flow to the brain, which causes...
-
Fibrin-based factor delivery for therapeutic angiogenesis: friend or foe?
Therapeutic angiogenesis aims at promoting the growth of blood vessels to restore perfusion in ischemic tissues or aid tissue regeneration. Vascular...
-
Angiogenesis after ischemic stroke
Owing to its high disability and mortality rates, stroke has been the second leading cause of death worldwide. Since the pathological mechanisms of...
-
Contributions of Wall Stretch and Shear Stress to Vascular Regulation: Molecular Mechanisms of Homeostasis and Expansion
Blood vessels are continuously exposed to hemodynamic forces due to the pulsatile nature of the blood flow. In normal physiological settings, these...
-
A Murine Model of Hind Limb Ischemia to Study Angiogenesis and Arteriogenesis
Therapeutic angiogenesis offers promise as a novel treatment that is complementary to surgical or endovascular procedures for peripheral arterial...
-
Biomechanics in Small Artery Remodeling
In this chapter, we discuss how biomechanical forces influence vascular design. We will focus on the small arteries and arterioles, i.e., those...
-
Brain-Derived Neurotrophic Factor and Vascular Endothelial Growth Factor A: Biomarkers Potential in Diabetes
Previously, brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF) have been studied only in diabetic neuropathy or...
-
How to Generate a Vascular-Labelled Transgenic Zebrafish Model to Study Tumor Angiogenesis and Extravasation
The use of transgenic animals carrying exogenous DNA integrated in their genome is a routine in modern-day laboratories. Nowadays, the zebrafish...
-
Unraveling the differential mechanisms of revascularization promoted by MSCs & ECFCs from adipose tissue or umbilical cord in a murine model of critical limb-threatening ischemia
BackgroundCritical limb-threatening ischemia (CLTI) constitutes the most severe manifestation of peripheral artery disease, usually induced by...
-
Long-term safety and efficacy of intramyocardial adenovirus-mediated VEGF-DΔNΔC gene therapy eight-year follow-up of phase I KAT301 study
In phase I KAT301 trial, intramyocardial adenovirus-mediated vascular endothelial growth factor -D ΔNΔC (AdVEGF-D) gene therapy (GT) resulted in a...
-
Galectin-1 Contributes to Vascular Remodeling and Blood Flow Recovery After Cerebral Ischemia in Mice
Galectin-1 is found in the vasculature and has been confirmed to promote angiogenesis in several cancer models. Furthermore, galectin-1 has been...
