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Argonaute-2 protects the neurovascular unit from damage caused by systemic inflammation
BackgroundThe brain vasculature plays a pivotal role in the inflammatory process by modulating the interaction between blood cells and the...
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Oligodendrocyte-specific Argonaute profiling identifies microRNAs associated with experimental autoimmune encephalomyelitis
BackgroundMicroRNAs (miRNAs) belong to a class of evolutionary conserved, non-coding small RNAs with regulatory functions on gene expression. They...
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RNA Interference in Experimental Animal Models: Its Application in Cancer Research and Therapy
Cancer, is a major health problem in the world, that has to be faced with new technologies and methods. Chemotherapy is still being widely used...
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Quantifying Argonaute 2 (Ago2) expression to stratify breast cancer
BackgroundArgonaute-2 (Ago2) is an essential component of microRNA biogenesis implicated in tumourigenesis. However Ago2 expression and localisation...
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Split-Luciferase Complementation Imaging Assay in Virus–Plant Interactions
Protein−protein interactions constitute the interface between a virus and the cell it infects and are crucial determinants of the outcome of the...
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Small Noncoding RNA, microRNA in Gene Regulation
A large portion of the human genome is devoted to producing noncoding RNA. A majority of ncRNA are involved in complex regulatory networks that...
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Mobile MicroRNAs: Potential for MicroRNA Biogenesis
As shown in Chap. 2 , the short interfering RNA (siRNA) system was thought to be the same as the microRNA (miRNA)...
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Critical appraisal of the piRNA-PIWI axis in cancer and cancer stem cells
Small noncoding RNAs play an important role in various disease states, including cancer. PIWI proteins, a subfamily of Argonaute proteins, and...
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Themes and variations on piRNA-guided transposon control
PIWI-interacting RNAs (piRNAs) are responsible for preventing the movement of transposable elements in germ cells and protect the integrity of...
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The role of exosome derived miRNAs in inter-cell crosstalk among insulin-related organs in type 2 diabetes mellitus
Exosomes are small extracellular vesicles secreted by almost all cell types, and carry diverse cargo including RNA, and other substances. Recent...
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RNA Interference: Story and Mechanisms
The discovery that gene expression can be silenced by exogenously introduced double-stranded RNAs into cells unveiled a hidden level of gene...
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SARS-CoV-2-associated organs failure and inflammation: a focus on the role of cellular and viral microRNAs
SARS-CoV-2 has been responsible for the recent pandemic all over the world, which has caused many complications. One of the hallmarks of SARS-CoV-2...
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MicroRNAs as Potential Biomarkers of Type 2 Diabetes Mellitus
AbstractMicroRNAs are small noncoding RNAs involved in post-transcriptional regulation of gene expression. In recent years, works demonstrating...
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A Machine Learning Approach to Identify Potential miRNA-Gene Regulatory Network Contributing to the Pathogenesis of SARS-CoV-2 Infection
Worldwide, many lives have been lost in the recent outbreak of coronavirus disease. The pathogen responsible for this disease takes advantage of the...
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An In Vitro Study for the Role of Schizophrenia-Related Potential miRNAs in the Regulation of COMT Gene
This study aimed to analyze the possible association of miR-30a-5p, miR-30e-5p, and miR-34a-5p identified as potential candidate miRNAs in...
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PiRNA pathway in the cardiovascular system: a novel regulator of cardiac differentiation, repair and regeneration
Piwi-interacting RNAs (piRNAs) are a novel group of small non-coding RNA molecules with lengths of 21–35 nucleotides, first identified from the...
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Relationship between PIWIL1 gene polymorphisms and epithelial ovarian cancer susceptibility among southern Chinese woman: a three-center case–control study
ObjectiveTo investigate the potential correlation between piwi-like RNA-mediated gene silencing 1 ( PIWIL1 ) polymorphisms and susceptibility to...
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MicroRNAs and Vascular Activity
MicroRNAs (miRNAs) are small single-stranded non-coding RNA molecules sized about 22 nucleotides that suppress mRNA translation via mRNA cleavage or...
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Non-coding RNAs as potential therapeutic targets for receptor tyrosine kinase signaling in solid tumors: current status and future directions
This review article presents an in-depth analysis of the current state of research on receptor tyrosine kinase regulatory non-coding RNAs (RTK-RNAs)...
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RNA Interference in Experimental Animal Models: Its Application in Cancer Research and Therapy
Cancer, is a major health problem in the world, that has to be faced with new technologies and methods. Chemotherapy is still being widely used...