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Area under the curve of tacrolimus using microsampling devices: towards precision medicine in solid organ transplantation?
PurposeTherapeutic drug monitoring of tacrolimus using trough concentration (C min ) is mandatory to ensure drug efficacy and safety in solid organ...
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A Simulation Study of the Comparative Performance of Partial Area under the Curve (pAUC) and Partial Area under the Effect Curve (pAUEC) Metrics in Crossover Versus Replicated Crossover Bioequivalence Studies for Concerta and Ritalin LA
Concerta and Ritalin LA are methylphenidate (MPH) drugs with different release mechanisms. Generic bioequivalence (BE) to these conventionally uses...
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An Explanation of Why Dose-Corrected Area Under the Curve for Alternate Administration Routes Can Be Greater than for Intravenous Dosing
It is generally believed that bioavailability ( F ) calculated based on systemic concentration area under the curve (AUC) measurements cannot exceed...
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Prediction model for milk transfer of drugs by primarily evaluating the area under the curve using QSAR/QSPR
PurposeInformation on milk transferability of drugs is important for patients who wish to breastfeed. The purpose of this study is to develop a...
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Pharmacokinetics of Imatinib Mesylate and Development of Limited Sampling Strategies for Estimating the Area under the Concentration–Time Curve of Imatinib Mesylate in Palestinian Patients with Chronic Myeloid Leukemia
Background and ObjectiveImatinib is a tyrosine kinase inhibitor used in the treatment of chronic myeloid leukemia (CML). The area under the...
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A Systematic Review of Multiple Linear Regression-Based Limited Sampling Strategies for Mycophenolic Acid Area Under the Concentration–Time Curve Estimation
Background and ObjectiveOne approach of therapeutic drug monitoring in the case of mycophenolic acid (MPA) is a limited sampling strategy (LSS),...
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Performance of Area under the Concentration-Time Curve Estimations of Vancomycin with Limited Sampling by a Newly Developed Web Application
PurposeTherapeutic drug monitoring guided by the area under the concentration-time curve (AUC-guided TDM) is recommended for vancomycin. However,...
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Bioequivalence Under the Prism of Finite Absorption Time
According to the finite absorption time, the area under the curve from zero to the end of the absorption processes, Ď„, namely [AUC]0Ď„, is the proper...
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Evaluation of Time-Dependent Cytochrome P450 Inhibition Using the Area Under the Curve Shift Method
New molecular entities (NMEs) causing time-dependent inhibition (TDI) of cytochrome P450 (CYP) enzymes are a concern because they can be responsible...
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Vancomycin Dosing: New Area-Under-the-Curve-Based Therapeutic Monitoring
Vancomycin, a glycopeptide approved by the FDA in 1958, is the cornerstone of treatment of methicillin-resistant Staphylococcus aureus infections....
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Gene expression signature predicts radiation sensitivity in cell lines using the integral of dose–response curve
BackgroundAlthough substantial efforts have been made to build molecular biomarkers to predict radiation sensitivity, the ability to accurately...
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On the use of receiver operating characteristic curve analysis to determine the most appropriate p value significance threshold
Backgroundp value is the most common statistic reported in scientific research articles. Choosing the conventional threshold of 0.05 commonly used...
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Estimation of the area under concentration-time curve of polymyxin B based on limited sampling concentrations in Chinese patients with severe pneumonia
AimsThe efficacy and toxicity of polymyxin B (PB) are closely related to its pharmacokinetic/pharmacodynamic (PK/PD) index area under the...
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Pharmacokinetics and bioequivalence evaluation of two oral formulations of cotrimoxazole tablets in healthy Chinese volunteers under fasting conditions
This bioequivalence study was conducted to evaluate two oral formulations of cotrimoxazole tablets in healthy Chinese subjects. All 26 subjects...
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Multivariate Curve Resolution for Analysis of Heterogeneous System in Toxicogenomics
The utilization of genetic data to investigate toxicological problems has become an imperative approach. Toxicogenomics (TGx), as a specialty branch...
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Prevalence and risk factors determinants of the non-use of insecticide-treated nets in an endemic area for malaria: analysis of data from Cameroon
BackgroundMalaria is the main cause of morbidity and mortality in Cameroon. Insecticide-treated nets (ITNs) significantly reduce malaria...
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Pharmacokinetics and bioequivalence evaluation of 2 oral formulations of methotrexate tablets in healthy Chinese volunteers under fasting and fed conditions
Methotrexate is an anti-metabolite drug that is frequently used for rheumatoid arthritis treatment. This study is aimed at evaluating the...
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Identification of hypothermia-inducing neurons in the preoptic area and activation of them by isoflurane anesthesia and central injection of adenosine
Hibernation and torpor are not passive responses caused by external temperature drops and fasting but are active brain functions that lower body...
