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Antigen
An antigen is a molecule which, when introduced parenterally into the body, initiates the production of an antibody with which it reacts specifically...
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Antigen-Presenting Cells and MHCs
In this chapter, we will discuss the principles of antigen presentation. We will learn that the major purpose of antigen-presenting cells, such as...
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Adaptive Immunity and Antigen Receptor Diversity
In this chapter, we will provide an overview on the roles of B and T cells in the response of the adaptive immune system to microbe invasion. In this...
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Chimeric antigen receptor T cell therapy for autoimmune disease
Infusion of T cells engineered to express chimeric antigen receptors (CARs) that target B cells has proven to be a successful treatment for B cell...
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Germline-enforced enrichment for charged amino acids in TCR beta chain (TCRβ) complementarity determining region 3 (CDR-B3) alters T cell development, repertoire content, and antigen recognition
T cell receptor beta chain (TCRβ) diversity (Dβ) gene segments are highly conserved across evolution, with trout Dβ1 sequence identical to human and...
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MR1 antigen presentation to MAIT cells and other MR1-restricted T cells
MHC antigen presentation plays a fundamental role in adaptive and semi-invariant T cell immunity. Distinct MHC molecules bind antigens that differ in...
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Role of Sialyl-Tn Antigen in Cancer Metastasis
Glycosylation is the most prominent posttranslational modification of proteins that regulates various protein functions and characteristics. Protein...
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A guide to antigen processing and presentation
Antigen processing and presentation are the cornerstones of adaptive immunity. B cells cannot generate high-affinity antibodies without T cell help....
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The antigen recognition portion of African buffalo class I MHC is highly polymorphic, consistent with a complex pathogen challenge environment, and the 3’ region suggests distinct haplotype configurations
African buffalo ( Syncerus caffer) have been distinct from the Auroch lineage leading to domestic cattle for 5 million years, and are reservoirs of...
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Redirecting Human Conventional and Regulatory T Cells Using Chimeric Antigen Receptors
The adaptive immune system exhibits exquisite specificity and memory and is involved in virtually every process in the human body. Redirecting...
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Information-Driven Antibody–Antigen Modelling with HADDOCK
In the recent years, therapeutic use of antibodies has seen a huge growth, "due to their inherent proprieties and technological advances in the...
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Therapeutic induction of antigen-specific immune tolerance
The development of therapeutic approaches for the induction of robust, long-lasting and antigen-specific immune tolerance remains an important unmet...
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Unraveling resistance mechanisms in anti-CD19 chimeric antigen receptor-T therapy for B-ALL: a novel in vitro model and insights into target antigen dynamics
BackgroundCellular immunotherapy, represented by the chimeric antigen receptor T cell (CAR-T), has exhibited high response rates, durable remission,...
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Immunization-induced antigen archiving enhances local memory CD8+ T cell responses following an unrelated viral infection
Antigens from viruses or immunizations can persist or are archived in lymph node stromal cells such as lymphatic endothelial cells (LEC) and...
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Map** the landscape: a bibliometric study of global chimeric antigen receptor T cell immunotherapy research
The rise of immunotherapy provided new approaches to cancer treatment. We aimed to describe the contribution of chimeric antigen receptor T cell...
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Evaluation of a new fusion antigen, cd loop and HAP2-GCS1 domain (cd-HAP) of Plasmodium falciparum Generative Cell Specific 1 antigen formulated with various adjuvants, as a transmission blocking vaccine
BackgroundMalaria is a major global health challenge, and for the elimination and eradication of this disease, transmission-blocking vaccines (TBVs)...
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Glyco-binding domain chimeric antigen receptors as a new option for cancer immunotherapy
In the last decade, treatment using Chimeric Antigen Receptor (CAR) are largely studied and demonstrate the potential of immunotherapeutic...
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Dendritic cell subsets in cancer immunity and tumor antigen sensing
Dendritic cells (DCs) exhibit a specialized antigen-presenting function and play crucial roles in both innate and adaptive immune responses. Due to...
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Mechanisms of resistance to chimeric antigen receptor-T cells in haematological malignancies
Chimeric antigen receptor (CAR)-T cells have recently emerged as a powerful therapeutic approach for the treatment of patients with...
