Search
Search Results
-
Antibiotic Adjuvants and Their Synergistic Activity Against ESKAPE Pathogens
ESAKPE pathogens are acquiring resistance to the conventional and modern therapeutic strategies, becoming difficult to eradicate. The development of...
-
Impact of antibiotic prophylaxis in second-stage surgery in joint prosthesis infection treated with two-stage exchange. A multicenter case–control study
IntroductionAfter two-stage exchange due to prosthetic joint infection (PJI), the new prosthesis carries a high risk of reinfection (RePJI). There...
-
The importance of antibiotic treatment duration in antimicrobial resistance
Antimicrobial resistance (AMR) poses a significant threat to global health, leading to increased deaths from drug-resistant infections and escalates...
-
Knowledge, attitudes and perceptions of Latin American healthcare workers relating to antibiotic stewardship and antibiotic use: a cross-sectional multi-country study
BackgroundThe burden of antimicrobial resistance (AMR) in Latin America is high. Little is known about healthcare workers’ (HCWs) knowledge,...
-
Dose selection for aztreonam-avibactam, including adjustments for renal impairment, for Phase IIa and Phase III evaluation
PurposeA series of iterative population pharmacokinetic (PK) modeling and probability of target attainment (PTA) analyses based on emerging data...
-
Knowledge, attitudes and behaviour of Egyptians towards antibiotic use in the community: can we do better?
BackgroundInfectious diseases are among the leading causes of death worldwide. This is concerning because of the increasing capacity of the pathogens...
-
Successful treatment of sino-pulmonary infection & skull base osteomyelitis caused by New Delhi metallo-β-lactamase-producing Pseudomonas aeruginosa in a renal transplant recipient by using an investigational antibiotic cefepime/zidebactam (WCK 5222)
A case of sino-pulmonary infection with skull base osteomyelitis due to XDR- Pseudomonas aeruginosa in renal transplant recipient was successfully...
-
Nitrofurantoin for the treatment of uncomplicated urinary tract infection in female patients: the impact of dosing regimen, age, and renal function on drug exposure
PurposeThe aim of this study is to determine nitrofurantoin exposure in female patients with different age and renal function with complaints of an...
-
A protective, single-visit TB vaccination regimen by co-administration of a subunit vaccine with BCG
The only licensed tuberculosis (TB) vaccine, Bacillus Calmette Guerin (BCG), fails to reliably protect adolescents and adults from pulmonary TB,...
-
Barriers to rational antibiotic prescription in Iran: a descriptive qualitative study
IntroductionRational antibiotic prescription (RAP) refers to the purposeful and appropriate antibiotic prescription with correct dose and course to...
-
Practices and challenges related to antibiotic use in paediatric treatment in hospitals and health centres in Niger and Uganda: a mixed methods study
BackgroundAntibiotic resistance is a significant public health problem and is responsible for high mortality in children and new-borns. Strengthening...
-
Determining effects of nitrate, arginine, and ferrous on antibiotic recalcitrance of clinical strains of Pseudomonas aeruginosa in biofilm-inspired alginate encapsulates
BackgroundBiofilms play a role in recalcitrance and treatability of bacterial infections, but majority of known antibiotic resistance mechanisms are...
-
Population Pharmacokinetics and Pharmacodynamics of Meropenem in Critically Ill Patients: How to Achieve Best Dosage Regimen According to the Clinical Situation
Background and ObjectivesMeropenem is frequently used for the treatment of severe bacterial infections in critically ill patients. Because critically...
-
Safety, pharmacokinetics, and food-effect of pivmecillinam after single- and multiple-dose in healthy Chinese subjects: a phase I study
Urinary tract infection (UTI) is one of the most prevalent bacterial infectious diseases worldwide. However, the resistance of urinary pathogens to...
-
Impact of collaborative physician-pharmacist stewardship strategies on prophylactic antibiotic practices: a quasi-experimental study
BackgroundAn effective use of surgical antibiotic prophylaxis (SAP) appears essential to prevent the development of infections linked to surgery...
-
An engineered live biotherapeutic for the prevention of antibiotic-induced dysbiosis
Antibiotic-induced alterations in the gut microbiota are implicated in many metabolic and inflammatory diseases, increase the risk of secondary...
-
Education level and misuse of antibiotics in the general population: a systematic review and dose–response meta-analysis
BackgroundNumerous studies evaluated the association of education level with misuse of antibiotics by the general population, yet divergent findings...
-
Superior protection in a relapsing Plasmodium cynomolgi rhesus macaque model by a chemoprophylaxis with sporozoite immunization regimen with atovaquone-proguanil followed by primaquine
BackgroundTo gain a deeper understanding of protective immunity against relapsing malaria, this study examined sporozoite-specific T cell responses...
-
Comparison of three doses of amikacin on alternate days with a daily dose of meropenem during the same period for the treatment of urinary tract infection with E. coli: a double-blind clinical trial
ObjectivesUrinary tract infections (UTIs) are very common infections in humans, and Escherichia coli ( E. coli ) is the commonest pathogen leading to...
-
Antibiotic modification versus withhold in febrile patients without evidence of bacterial infection, unresponsive to initial empiric regimen: a multicentre retrospective study conducted in Israel
Prescribing antibiotics for febrile patients without proof of bacterial infection contributes to antimicrobial resistance. Lack of clinical response...
