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Role of Dendrimers in Management of Allergic Airway Diseases
Dendrimers are three-dimensional polymers that are characterized by their precisely structured hyper-branches and present a cutting-edge polymeric...
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Moringa oleifera and Its Biochemical Compounds: Potential Multi-targeted Therapeutic Agents Against COVID-19 and Associated Cancer Progression
The Coronavirus disease-2019 (COVID-19) pandemic is a global concern, with updated pharmacological therapeutic strategies needed. Cancer patients...
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The journey of boswellic acids from synthesis to pharmacological activities
There has been a lot of interest in using naturally occurring substances to treat a wide variety of chronic disorders in recent years. From the gum...
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Scutellarin Alleviates Ovalbumin-Induced Airway Remodeling in Mice and TGF-β-Induced Pro-fibrotic Phenotype in Human Bronchial Epithelial Cells via MAPK and Smad2/3 Signaling Pathways
Asthma is a chronic inflammatory disease characterized by airway hyperresponsiveness (AHR), inflammation, and remodeling. Epithelial-mesenchymal...
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Meteorin-β/Meteorin like/IL-41 attenuates airway inflammation in house dust mite-induced allergic asthma
We sought to examine the regulatory effect of Meteorin-β (Metrnβ)/Meteorin like (Metrnl)/IL-41 on lung inflammation in allergic asthma. We found that...
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Polystichum braunii ameliorates airway inflammation by attenuation of inflammatory and oxidative stress biomarkers, and pulmonary edema by elevation of aquaporins in ovalbumin-induced allergic asthmatic mice
Asthma is a chronic inflammation of pulmonary airways associated with bronchial hyper-responsiveness. The study was aimed to validate the folkloric...
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Asthma-Induced Inflammatory Responses and Reversal by Botanicals
Asthma is the most prevailing chronic inflammatory medical condition which is the outcome of extensive air pollution and which is associated with...
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Machine learning-aided search for ligands of P2Y6 and other P2Y receptors
The P2Y 6 receptor, activated by uridine diphosphate (UDP), is a target for antagonists in inflammatory, neurodegenerative, and metabolic disorders,...
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Three-dimensional environment sensitizes pancreatic cancer cells to the anti-proliferative effect of budesonide by reprogramming energy metabolism
BackgroundPancreatic ductal adenocarcinoma (PDAC) is the most lethal cancer with an aggressive metastatic phenotype and very poor clinical prognosis....
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Exploring the therapeutic potential of monoclonal antibodies targeting TSLP and IgE in asthma management
BackgroundIn recent years, there has been a growing interest in the utilization of biologic therapies for the management of asthma. Both TSLP and IgE...
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Beneficial role of kaempferol and its derivatives from different plant sources on respiratory diseases in experimental models
Respiratory illnesses impose a significant health burden and cause deaths worldwide. Despite many advanced strategies to improve patient outcomes,...
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Carbon Nanotubes (CNTs): A Novel Therapeutic Approach in the Management of Allergic Airway Diseases
Globally, allergic airway diseases caused immense threats with increased mortality rates. Current pharmacological agents have resulted in poor...
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AMPK Regulates M1 Macrophage Polarization through the JAK2/STAT3 Signaling Pathway to Attenuate Airway Inflammation in Obesity-Related Asthma
Abstract —Obesity-related asthma is primarily characterized by nonallergic inflammation, with pathogenesis involving oxidative stress, metabolic...
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Clinical Trials and Outcomes in Anti-inflammatory Therapies
Inflammatory diseases represent a diverse group of disorders stemming from an overactive immune response, affecting various organs and tissues and...
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Immunology of Allergic Airway Diseases
Allergies have a similar immunological profile constituted up of recognizable cells, antibodies, and other biochemical and molecular structures. It...
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Myrtenol Inhalation Mitigates Asthma-Induced Cognitive Impairments: an Electrophysiological, Behavioral, Histological, and Molecular Study
Asthma is an inflammatory disorder with significant health problems. It generally affects the lungs but can also impact brain performance via several...
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Akebia saponin D attenuates allergic airway inflammation through AMPK activation
Akebia saponin D (ASD) is a bioactive triterpenoid saponin extracted from Dipsacus asper Wall. ex DC.. This study aimed to investigate the effects of...
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Classification of the present pharmaceutical agents based on the possible effective mechanism on the COVID-19 infection
ObjectivesThere are several types of research on the COVID-19 disease which have been conducting. It seems that prevailing over the pandemic would be...
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Cannabinoids as Promising Anti-inflammatory Agent
Inflammation is a reaction of immune system to external stress conditions or any microbial attack on body, or it may be followed by autoimmune...
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Nanoparticles Solutions for Allergic Airway Disorders: Current Trends and Future Prospects
The present work explores the world of nanoparticles as a potential solution, for addressing allergic airway diseases. The ailments, such as asthma...