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Unraveling Emerging Anal Cancer Clinical Biomarkers from Current Immuno-Oncogenomics Advances
Anal squamous cell carcinoma (ASCC) is a rare gastrointestinal malignancy associated with high-risk human papillomavirus (HPV) and is currently one...
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Awareness of the causal association between human papillomavirus and anal cancer among US adults
PurposeThe incidence of anal cancer is on the rise in the US, especially among high-risk groups. This study examined the prevalence and determinants...
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Microbiome-derived cobalamin and succinyl-CoA as biomarkers for improved screening of anal cancer
Human papillomavirus can cause preinvasive, high-grade squamous intraepithelial lesions (HSILs) as precursors to cancer in the anogenital area, and...
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ROAR-A: re-optimization based Online Adaptive Radiotherapy of anal cancer, a prospective phase II trial protocol
BackgroundChemo-radiotherapy with curative intent for anal cancer has high complete remission rates, but acute treatment-related gastrointestinal...
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Psychometric Validation of the Patient Anal Cancer Knowledge Scale (PACKS) in a Cohort of Black and Hispanic/Latino Sexual and Gender Diverse Young Adults
Lack of anal cancer information in priority populations is a major barrier to the uptake and utilization of prevention services. A validated measure...
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Prognostic factors for patients with anal cancer treated with conformal radiotherapy—a systematic review
AimsAnal cancer is primarily treated using concurrent chemoradiotherapy (CRT), with conformal techniques such as intensity modulated radiotherapy...
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The effect of recombinant human epidermal growth factor on radiation dermatitis in rectal and anal cancer patients: a self-controlled study
BackgroundOur previous study reported that recombinant human epidermal growth factor (rhEGF)-triggered EGFR internalization promoted radioresistance....
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Necessity of external iliac lymph nodes and inguinal nodes radiation in rectal cancer with anal canal involvement
Background and purposeWe aimed to explore the necessity of the external iliac lymph nodes (EIN) along with inguinal nodes (IN) region in clinical...
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The impact of body mass index and physical disability on home-based anal self-sampling
PurposeSelf-sampling is increasingly being used in screening programs, yet no studies to date have examined the impact of bodily characteristics on...
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Dentate line invasion as a predictive factor of poor distant relapse-free survival in locally advanced lower rectal cancer with anal sphincter involvement
BackgroundWhile an important surgical landmark of the dentate line has been established for locally advanced lower rectal cancer (LALRC), the...
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Sarcopenia and dosimetric parameters in relation to treatment-related leukopenia and survival in anal cancer
BackgroundTreatment-related white blood cell (WBC) toxicity has been associated with an inferior prognosis in different malignancies, including anal...
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Management of non-metastatic anal cancer in the elderly: ancillary study of the French multicenter prospective cohort FFCD-ANABASE
BackgroundStandard care for non-metastatic squamous cell carcinoma of the anus (SCCA) is chemoradiotherapy, data about elderly patients are scarce.
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HPV-Associated Anal Cancer Knowledge, Attitudes, and Health Communication Behaviors Among Non-clinical Providers at HIV/AIDS Service Organizations in Southern United States Region
Co-infection with HIV/HPV and bio-behavioral risk factors (e.g., immunodeficiency, un-protected sex) increase likelihood for develo** anal and...
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Pelvic U-Net: multi-label semantic segmentation of pelvic organs at risk for radiation therapy anal cancer patients using a deeply supervised shuffle attention convolutional neural network
BackgroundDelineation of organs at risk (OAR) for anal cancer radiation therapy treatment planning is a manual and time-consuming process. Deep...
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The association between protease inhibitors and anal cancer outcomes in veterans living with HIV treated with definitive chemoradiation: a retrospective study
BackgroundThe incidence of anal squamous cell carcinoma has been increasing, particularly in people living with HIV (PLWH). There is concern that...
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Inflammation and Cancer
Virchow (1864) observed that tumor stroma is frequently invaded by inflammatory cells and proposed a relationship between inflammation and cancer for...
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Patterns of pathologic lymph nodes in anal cancer: a PET-CT-based analysis with implications for radiotherapy treatment volumes
BackgroundThis study investigates the patterns of PET-positive lymph nodes (LNs) in anal cancer. The aim was to provide information that could inform...
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The Road to Cervical Cancer Elimination
An estimated 34,800 cancers in the United States were caused by HPV between 2012 and 2016. Among those cancers (cervical, vulvar, vaginal, anal,...
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Perspectives of Immunotherapy in Prostate Cancer
Prostate cancer, a major twenty-first-century health concern, often remains asymptomatic in its early stages but can lead to urinary, pelvic, and...