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A recombinant measles virus vaccine strongly reduces SHIV viremia and virus reservoir establishment in macaques
Replicative vectors derived from live-attenuated measles virus (MV) carrying additional non-measles vaccine antigens have long demonstrated safety...
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Construction of a replication-competent retroviral vector for expression of the VSV-G envelope glycoprotein for cancer gene therapy
Gibbon ape leukemia virus (GALV) can infect a wide variety of cells but fails to infect most cells derived from laboratory mice. Transduction of...
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Mesenchymal Stem Cell Mediated Suicide Gene Therapy
An ocean of evidence points toward feasibility of applying gene therapy-based methods to manifest a prolonged remedial impact. Mesenchymal Stem Cells...
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Mesenchymal Stem Cell-Mediated Suicide Gene Therapy
An ocean of evidence points toward feasibility of applying gene therapy-based methods to manifest a prolonged remedial impact. Mesenchymal Stem Cells...
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HIV-1 restriction by SERINC5
Serine incorporator 5 (SERINC5 or SER5) is a multipass transmembrane protein with ill-defined cellular activities. SER5 was recently described as a...
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Measuring Neutralizing Antibodies to SARS-CoV-2 Using Lentiviral Spike-Pseudoviruses
Assays measuring neutralizing antibodies (nAbs) against SARS-CoV-2 are used to evaluate serological responses after SARS-CoV-2 infection and the...
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Pharmacology of Mammalian Na+-Dependent Transporters of Inorganic Phosphate
Inorganic phosphate (Pi) is an essential component of many biologically important molecules such as DNA, RNA, ATP, phospholipids, or apatite. It is...
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Advanced Therapy Medicinal Products: Clinical, Non-clinical, and Quality Considerations
Cell therapy, tissue engineering, and gene therapy products, together called “advanced therapy medicinal products” (ATMPs), represent a heterogeneous...
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The stability of envelope-pseudotyped lentiviral vectors
Lentiviral vectors have become popular tools for stable genetic modification of mammalian cells. In some applications of lentiviral vector-transduced...
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High levels of Daxx due to low cellular levels of HSP25 in murine cancer cells result in inefficient adenovirus replication
When the adenoviral protein E1B55K binds death domain-associated protein (Daxx), the proteasome-dependent degradation of Daxx is initiated, and...
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Virus-Mediated Cancers in Animals
Ever since the discovery of the first tumour-associated virus in hen by Peyton Rous in 1911, cancer-causing viruses have been extensively...
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Introduction to Oncolytic Virotherapy
Oncolytic viruses exploit key hallmarks of cancer for replication in malignant cells, leading to tumor cell lysis, modulation of the tumor...
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Dual-vector prodrug activator gene therapy using retroviral replicating vectors
Retroviral replicating vectors (RRVs) have been shown to achieve efficient tumor transduction and enhanced therapeutic benefits in a variety of...
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Efficient tumor transduction and antitumor efficacy in experimental human osteosarcoma using retroviral replicating vectors
Retroviral replicating vectors (RRVs) have achieved efficient tumor transduction and enhanced therapeutic benefit in a wide variety of cancer models....
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Assessments of different batches and dose levels of a two-dose Ad26.ZEBOV and MVA-BN-Filo vaccine regimen
Two phase 3 clinical studies were conducted in the USA to bridge across different Ad26.ZEBOV manufacturing processes and sites, and to evaluate the...
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A heterogeneous human immunodeficiency virus-like particle (VLP) formulation produced by a novel vector system
First identified as the etiological agent behind Acquired Immunodeficiency Syndrome (AIDS) in the early 1980s, HIV-1 has continued to spread into a...
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Potent and reversible lentiviral vector restriction in murine induced pluripotent stem cells
BackgroundRetroviral vectors are derived from wild-type retroviruses, can be used to study retrovirus-host interactions and are effective tools in...
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Methioninase Gene Therapy
Recombinant methioninase (rMETase) derived from Pseudomonas putida targets the elevated methionine (MET) requirement of cancer cells (methionine...