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Design, synthesis and antimicrobial activities of 1,2,3-triazole hybrids with amine-ester functionality
Due to the notable therapeutic importance of 1,4-disubstituted-1,2,3-triazoles linked with amine and ester groups, a series of 1,2,3-triazole hybrid...
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Hazardous 2,4,6-Trinitrophenol (TNP) Detection in Water by Amine and Azine Functionalized Metal–Organic Framework
A Zn(II)-based metal–organic framework (MOF) decorated with amine and azine functionalities, TMU-17-NH 2 (formulated as [Zn(H2ata)(L)].2DMF;...
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Discovery of HNPC-A188: a novel acaricide containing trifluoroethyl thioether and pyrimidin-4-amine
Pyrimidifen is an excellent commercial acaricide, but it is not low toxic to mammals. Trifluoroethyl thioether derivatives exhibit excellent...
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Phenoxyalkyl cyclic and acyclic amine derivatives: what do they teach us about scaffold-based drug design?
Fragment-based drug design of new bioactive scaffolds is a recent aspect of medicinal chemistry that provides a faster and more efficient road in...
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Preliminary structure−activity relationships analysis on N-(3,5-dichlorophenyl)-4,5-dihydronaphtho[1,2-d]thiazol-2-amine, a disruptor of mycobacterial energetics
The increasing emergence of drug-resistance among mycobacteria represents a serious global health threat, requiring novel and effective therapeutic...
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Amine-modified nanoplastics promote the procoagulant activation of isolated human red blood cells and thrombus formation in rats
BackgroundMicroplastics (MPs) and nanoplastics (NPs) formed from decomposed plastic are increasing environmental threats. Although MPs and NPs...
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Trace amine associated receptor 1: predicted effects of single nucleotide variants on structure-function in geographically diverse populations
Trace Amine Associated Receptor 1 (TAAR1) is a novel pharmaceutical target under investigation for the treatment of several neuropsychiatric...
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Amine-decorated Zirconium Based Metal Organic Framework for Ultrafast Detection of 2,4,6-Trinitrophenol in Aqueous Samples
An amine-decorated zirconium based metal organic framework (MOF) UiO-66-NH 2 with rod shape morphology was synthesized by solvothermal process using...
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ADRA2B and HTR1A: An Updated Study of the Biogenic Amine Receptors Reveals Novel Conserved Motifs Which Play Key Role in Mental Disorders
Mental disorders are strongly connected with several psychiatric conditions including depression, bipolar disorder, schizophrenia, eating disorder,...
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Design, synthesis, and biological evaluation of new 2-(4-(methylsulfonyl)phenyl)-N-phenylimidazo[1,2-a]pyridin-3-amine as selective COX-2 inhibitors
Cyclooxygenase (COX), which plays a role in converting arachidonic acid to inflammatory mediators, could be inhibited by non-steroidal...
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A Novel D-π-A Type Fluorescent Probe for Cu2+ Based on Styryl-Pyridinium Salts Conjugating Di-(2-picolyl)amine (DPA) Units
A novel D-π-A type fluorescent probe L(NO 3 ) for Cu (II) sensing was designed and fully characterized. The probe consists of a styryl-pyridine cation...
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The Synergistic Mechanisms of AIE, ESIPT and ICT in the α-cyanostilbene-based Derivative: A Red-fluorescence Probe With a Large Stokes’ Shift for Copper (II) Ion Determination and Reversible Response to Amine/acid Vapor
Herein, α-cyanostilbene-based luminogen with an electron donor-π-electron acceptor (D-π-A) architecture was formylated into the...
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Olfactory signaling via trace amine-associated receptors
Trace amine-associated receptors (TAARs) are a family of G protein-coupled receptors that function as odorant receptors in the main olfactory system...
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Fluorescent Sensors for Hg2+ and Cu2+ Based on Condensation Products of 4H-1,2,4 Triazole-4-Amine and Carboxylated Benzoic Acids
Mercury (Hg) causes serious health issues in its all forms. Deficiency as well as excess of copper ion (Cu 2+ ) in human body is hazardous. A series of...
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The effect of the rs1799931 G857A (G286E) polymorphism on N-acetyltransferase 2-mediated carcinogen metabolism and genotoxicity differs with heterocyclic amine exposure
Human N -acetyltransferase 2 (NAT2) is subject to genetic polymorphism in human populations. In addition to the reference NAT2*4 allele, two genetic...
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Secondary biogenic amine deficiencies: genetic etiology, therapeutic interventions, and clinical effects
Monoamine neurotransmitter disorders present predominantly with neurologic features, including dystonic or dyskinetic cerebral palsy and movement...
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Cardioprotective Effect of Opioids, Derivatives of Amide N-Methyl-2-(Pirrolidin-1-yl)Cyclohexyl-1-Amine, under Conditions of Ischemia/Reperfusion of the Heart
We performed a comparative analysis of infarction-limiting activity of analogues of opioid receptor agonist U-50488 under conditions of heart...
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Dietary heterocyclic aromatic amine intake and cancer risk: epidemiological evidence from Japanese studies
Heterocyclic aromatic amines (HAAs), which are formed from the reaction of creatine or creatinine, amino acids, and sugars in meat and fish cooked at...
