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γδ T cells in oral diseases
Objectiveγδ T cells are a distinct subset of unconventional T cells, which link innate and adaptive immunity by secreting cytokines and interacting...
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Double-edged sword: γδ T cells in mucosal homeostasis and disease
The mucosa is a tissue that covers numerous body surfaces, including the respiratory tract, digestive tract, eye, and urogenital tract. Mucosa is in...
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Local γδ T cells: translating promise to practice in cancer immunotherapy
Rapid bench-to-bedside translation of basic immunology to cancer immunotherapy has revolutionised the clinical practice of oncology over the last...
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γδ T cells and the PD-1/PD-L1 axis: a love–hate relationship in the tumor microenvironment
Gamma delta (γδ) T cells demonstrate strong cytotoxicity against diverse cancer cell types in an MHC-independent manner, rendering them promising...
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Exhausted intratumoral Vδ2− γδ T cells in human kidney cancer retain effector function
Gamma delta (γδ) T cells reside within human tissues including tumors, but their function in mediating antitumor responses to immune checkpoint...
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Unconventional T Cells Influence Clinical Outcome After Allogeneic Hematopoietic Cell Transplantation
We evaluated the impact of early recovery of mucosal-associated invariant T cells (MAIT) and gamma-delta (γδ) T cells, especially Vδ2 + T cells, on...
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The Role of Innate T Cells in Cancer
Innate T cells, comprising invariant natural killer T (iNKT) cells, gamma delta T (γδ T) cells, and mucosal-associated invariant T (MAIT) cells,...
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The Role of Gamma Delta T Cells in Cancer
γδ T cells are a group of T lymphocytes known as nonconventional T cells. They are able to interact with a diverse range of antigens independent from...
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Development of Immune Cell Therapy Using T Cells Generated from Pluripotent Stem Cells
In the field of cancer immunotherapy, the effectiveness of a method in which patient-derived T cells are genetically modified ex vivo and...
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Emerging Innate Immune Cells in Cancer Immunotherapy: Promises and Challenges
Immune checkpoint inhibitor (ICI)-based therapy has made an unprecedented impact on survival benefit for a subset of cancer patients; however, only a...
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Generation of T-cell-receptor-negative CD8αβ-positive CAR T cells from T-cell-derived induced pluripotent stem cells
The production of autologous T cells expressing a chimaeric antigen receptor (CAR) is time-consuming, costly and occasionally unsuccessful....
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Primary Culture of Immunological Cells
This chapter begins with a brief description of the mechanisms associated with maintaining immunity (protection against disease-causing pathogens) in...
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Cancer immunotherapy with γδ T cells: many paths ahead of us
γδ T cells play uniquely important roles in stress surveillance and immunity for infections and carcinogenesis. Human γδ T cells recognize and kill...
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Allogenic and autologous anti-CD7 CAR-T cell therapies in relapsed or refractory T-cell malignancies
Chimeric antigen receptor-T (CAR-T) therapy remains to be investigated in T-cell malignancies. CD7 is an ideal target for T-cell malignancies but is...
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Innate lymphoid cells and innate-like T cells in cancer — at the crossroads of innate and adaptive immunity
Immunotherapies targeting conventional T cells have revolutionized systemic treatment for many cancers, yet only a subset of patients benefit from...
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