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Therapeutic potential of oleanolic acid in liver diseases
Liver-associated diseases affect millions of individuals worldwide. In developed countries, the incidence of viral hepatitis is reducing due to...
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Pathogenic mechanisms and regulatory factors involved in alcoholic liver disease
Alcoholism is a widespread and damaging behaviour of people throughout the world. Long-term alcohol consumption has resulted in alcoholic liver...
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Mechanisms of the TGF-β1/Smad3-signaling pathway in gender differences in alcoholic liver fibrosis
The TGF-β1/Smad3-signaling pathway and gender differences were investigated in alcoholic liver fibrosis. Mice were divided into female normal, female...
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Exploring the interplay of gut microbiota, inflammation, and LDL-cholesterol: a multiomics Mendelian randomization analysis of their causal relationship in acute pancreatitis and non-alcoholic fatty liver disease
BackgroundAcute pancreatitis and non-alcoholic fatty liver disease are both serious diseases in the digestive system. The pathogenesis of both...
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Trimethylamine-N-oxide, a New Risk Factor for Non-alcoholic Fatty Liver Disease Changes the Expression of miRNA-34a, and miRNA-122 in the Fatty Liver Cell Model
Non-alcoholic fatty liver disease is a multifactorial disorder with complicated pathophysiology ranging from simple steatosis to steatohepatitis and...
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Changes in Microcirculation in the Brain, Heart, and Liver in Female Rats with Translational Model of Alcoholic Cardiomyopathy
We studied some features of blood and lymph microcirculation in the brain, heart, and liver of female rats with developed alcoholic cardiomyopathy....
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The protective effects of Nin**’yoeito against liver steatosis/fibrosis in a non-alcoholic steatohepatitis model mouse
Non-alcoholic steatohepatitis (NASH) is a progressive fibrotic form of non-alcoholic fatty liver disease. Liver fibrosis leads to liver cancer and...
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Autoimmune hepatitis displays distinctively high multi-antennary sialylation on plasma N-glycans compared to other liver diseases
BackgroundChanges in plasma protein glycosylation are known to functionally affect proteins and to associate with liver diseases, including cirrhosis...
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Blood Level of Nitric Oxide Metabolites and Expression of Genes Regulating NO Synthesis in Early Forms of Non-Alcoholic Fatty Liver Disease
The levels of NO metabolites in the plasma and mRNA of the NOS3 , ATG9B , and NOS2 genes in peripheral blood leukocytes of healthy people and patients...
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The gut-liver axis in hepatobiliary diseases
Recent advances in the analysis of intestinal bacteria have led to reports of variations in intestinal bacterial levels among hepatobiliary diseases....
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Ginkgolide C attenuated Western diet-induced non-alcoholic fatty liver disease via increasing AMPK activation
BackgroundNon-alcoholic steatohepatitis (NASH) is a metabolic dysregulation-related disorder that is generally characterized by lipid metabolism...
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Immunogenic necroptosis in liver diseases: mechanisms and therapeutic potential
Necroptosis has received increasing attention and is extensively studied as a recently discovered mode of cell death distinct from necrosis and...
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The dual function of cGAS-STING signaling axis in liver diseases
Numerous liver diseases, such as nonalcoholic fatty liver disease, hepatitis, hepatocellular carcinoma, and hepatic ischemia-reperfusion injury, have...
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Associations of perfluoroalkyl substances with metabolic-associated fatty liver disease and non-alcoholic fatty liver disease: NHANES 2017–2018
ObjectivesThis study investigated the potential effects of perfluoroalkyl substance (PFAS) in serum on MAFLD, NAFLD, and liver fibrosis.
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Role of Renin-Angiotensin System in the Pathogenesis and Progression of Non-alcoholic Fatty Liver
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver diseases and is increasing simultaneously with obesity and Type 2...
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Mitochondrial metabolic dysfunction and non-alcoholic fatty liver disease: new insights from pathogenic mechanisms to clinically targeted therapy
Metabolic dysfunction-associated fatty liver disease (MAFLD) is among the most widespread metabolic disease globally, and its associated...
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Non–small cell lung cancer and immune checkpoint inhibitor therapy: does non-alcoholic fatty liver disease have an effect?
BackgroundImmunotherapy based on the application of immune checkpoint inhibitors (ICIs) is one of the standard treatments for advanced non-small cell...
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Liver receptor homolog-1: structures, related diseases, and drug discovery
Liver receptor homolog-1 (LRH-1), a member of the nuclear receptor superfamily, is a ligand-regulated transcription factor that plays crucial roles...
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Sex differences in the association between adipose insulin resistance and non-alcoholic fatty liver disease in Chinese adults
BackgroundAdipose insulin resistance (Adipo-IR) is associated with multiple metabolic diseases, including non-alcoholic fatty liver disease (NAFLD)....
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Study on the mechanism of vitamin E alleviating non-alcoholic fatty liver function based on non-targeted metabolomics analysis in rats
Non-alcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic syndrome. Vitamin E (VE) has antioxidant properties and can mediate...
